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University and University Hospital Zurich

2 ARTICLES PUBLISHED IN JoVE

Medicine

Rat Model of the Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy (ALPPS) Procedure

Erik Schadde^1,2,3, Martin Hertl², Stefan Breitenstein³, Beatrice Beck-Schimmer^1,4, Martin Schläpfer^1,4

¹Institute of Physiology - Center for Integrative Human Physiology, University of Zurich, ²Department of Surgery, Rush University Medical Center, ³Department of Surgery, Cantonal Hospital Winterthur, ⁴Institute of Anesthesiology, University and University Hospital Zurich

Inducing rapid liver hypertrophy using Associating Liver Partition and Portal vein ligation for a Staged hepatectomy (ALPPS) has been proposed for resection of borderline resectable liver tumors. This model may elucidate mechanisms involved in rapid hypertrophy and allows testing of drugs that promote or block the acceleration of regeneration.

Medicine

A Reproducible Intensive Care Unit-Oriented Endotoxin Model in Rats

Jan Heil¹, Martin Schläpfer^1,2

¹Institute of Physiology, University of Zurich, ²Institute of Anesthesiology, University Hospital of Zurich

Here, we present a reproducible intensive care unit-oriented endotoxin model in rats.