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BC Children's Hospital and University of British Columbia

1 ARTICLES PUBLISHED IN JoVE

JoVE Journal

Screening Bioactive Nanoparticles in Phagocytic Immune Cells for Inhibitors of Toll-like Receptor Signaling

Hong Yang¹, Shan Yu Fung², Aihua Bao¹, Qiang Li¹, Stuart E. Turvey²

¹Department of Respiratory Medicine, Shanghai First People's Hospital, Shanghai Jiaotong University School of Medicine, ²Department of Pediatrics, BC Children's Hospital and University of British Columbia

Toll-like receptor (TLR) signaling plays an important role in the pathophysiology of many human inflammatory diseases, and regulating TLR responses by bioactive nanoparticles is anticipated to be beneficial in many inflammatory conditions. THP-1 cell-based reporter cells provide a versatile and robust screening platform for identifying novel inhibitors of TLR signaling.