Assessing Pupil-linked Changes in Locus Coeruleus-mediated Arousal Elicited by Trigeminal StimulationMaria Paola Tramonti Fantozzi *1, Tommaso Banfi *2,3, Vincenzo De Cicco *1, Massimo Barresi 4, Enrico Cataldo 5, Davide De Cicco 1, Luca Bruschini 6, Paola d'Ascanio 1, Gastone Ciuti 2,3, Ugo Faraguna 1,7, Diego Manzoni 1
1Department of Translational Research and of New Surgical and Medical Technologies, University of Pisa, 2The BioRobotics Institute, Scuola Superiore Sant'Anna, 3Department of Excellence in Robotics & AI, Scuola Superiore Sant'Anna, 4Institut des Maladie Neurodegeneratives, University of Bordeaux, 5Department of Physics, University of Pisa, 6Department of Surgical, Medical, Molecular Pathology and Critical Care Medicine, University of Pisa, 7Department of Developmental Neuroscience, IRCCS Foundation Stella Maris
To verify whether trigeminal effects on cognitive performance involve locus coeruleus activity, two protocols are presented that aim to evaluate possible correlations between the performance and task-related pupil size changes induced by chewing. These protocols may be applied to conditions in which locus coeruleus contribution is suspected.
