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Medical faculty of the University of Tübingen

2 ARTICLES PUBLISHED IN JoVE

Bioengineering

Application of Atomic Force Microscopy to Detect Early Osteoarthritis

Marina Danalache^*1, Aadhya Tiwari^*1, Viktor Sigwart^1,2, Ulf Krister Hofmann^1,3

¹Laboratory of Cell Biology, Department of Orthopaedic Surgery, University Hospital of Tübingen, ²Medical faculty of the University of Tübingen, ³Department of Orthopaedic Surgery, University Hospital of Tübingen

We present a method to investigate early osteoarthritic changes at the cellular level in articular cartilage by using atomic force microscopy (AFM).

Biology

Optical Sectioning and Visualization of the Intervertebral Disc from Embryonic Development to Degeneration

Florian Christof Bonnaire^1,2, Martina Feierabend³, Julius Michael Wolfgart^1,4, Wolfram Breuer⁵, Christian Walter², Ulf Krister Hofmann^1,2, Marina Danalache¹

¹Laboratory of Cell Biology, Department of Orthopedic Surgery, University Hospital of Tübingen, ²Department of Orthopedic Surgery, University Hospital of Tübingen, ³Institute for Bioinformatics and Medical Informatics, Faculty of science of the University of Tübingen, ⁴Medical faculty of the University of Tübingen, ⁵Bavarian Health and Food Safety Authority

We present a method to investigate spatial chondrocyte organization in the anulus fibrosus of the intervertebral disc using an optical sectioning method.