Delivery of Cardioactive Therapeutics in a Porcine Myocardial Infarction ModelDinesh Selvakumar *1,2, Emma Wilkie *1, Tejas Deshmukh 1,2, Dhanya Ravindran 1, Yasuhito Kotake 2, Juntang Lu 2, Tony Barry 2, Vu Tran 2, Hugh Paterson 3, Alfred Hing 4, Timothy Campbell 2, Saurabh Kumar 2, Eddy Kizana 1,2, James J. H. Chong 1,2
1Centre for Heart Research, The Westmead Institute for Medical Research, The University of Sydney, 2Department of Cardiology, Westmead Hospital, 3Sydney Imaging, Core Research Facility, The University of Sydney, 4Department of Cardiothoracic Surgery, Liverpool Hospital
The present protocol describes three methods of administering cardioactive therapeutic agents in a porcine model. Female landrace swine received treatment through either: (1) thoracotomy and transepicardial injection, (2) catheter-based transendocardial injection, or (3) intravenous infusion via jugular vein osmotic minipump.
