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Central Washington University

2 ARTICLES PUBLISHED IN JoVE

JoVE Journal

Characterizing Far-infrared Laser Emissions and the Measurement of Their Frequencies

¹Department of Physics, Central Washington University, ²Department of Physics, University of Wisconsin-La Crosse, ³College of Science and Technology, Millersville University

We describe the generation of far-infrared radiation using an optically pumped molecular laser along with the measurement of their frequencies with heterodyne techniques. The experimental system and techniques are demonstrated using difluoromethane (CH₂F₂) as the laser medium whose results include three new laser emissions and eight measured laser frequencies.

Chemistry

A Direct, Early Stage Guanidinylation Protocol for the Synthesis of Complex Aminoguanidine-containing Natural Products

Christopher E. Malmberg¹, Stephen Chamberland²

¹Department of Chemistry, Central Washington University, ²Department of Chemistry, Utah Valley University

Here, we present a protocol for direct, early stage guanidinylation that enables rapid total synthesis of aminoguanidine-containing small organic molecules. An advanced synthetic intermediate used in the synthesis of a blood coagulation factor XIa inhibitor was prepared using this protocol.