Francesco Simone Ruggeri
Centre for Misfolding Diseases,
Department of Chemistry,
Centre for Misfolding Diseases, Department of Chemistry
University of Cambridge
Francesco Simone Ruggeri is a Junior Research fellow at the Darwin College and Research Fellow at the Department of Chemistry & Centre for Misfolding disease at University of Cambridge. He holds a PhD in biophysics obtained in 2015 at the École Polytechnique Fédérale de Lausanne (EPFL) in Switzerland, where he acquired a strong expertise on scanning probe microscopy and single molecule methods.
In his research, he continuously push the boundaries of the methods of analysis of modern biology and physics for investigating complex and heterogeneous biological samples and biomaterials at the nanoscale. I have deep expertise in scanning probe microscopy, surface science, spectroscopy, data analysis, image processing and single particle characterisation.
The objective of his present and future research is the development and application of novel Physical methods at the interface with Chemistry and Biology to shed light on the molecular processes underlying the onset of neurodegenerative disorders and study functional biomaterials for biomedical applications.
In particular, he has first demonstrated the application of peak-force tapping mode and of infrared nanospectroscopy (AFM-IR) to correlate the nanomechanical, chemical and structural properties of biological samples at the nanoscale in air and liquid environment. This approach has brought new insights into the formation and structural characterization of misfolding of proteins and their correlation with the onset of neurodegenerative disorders.
Nanoscale spatially resolved infrared spectra from single microdroplets.
Lab on a chip Apr, 2014 | Pubmed ID: 24519414
AFM-Based Single Molecule Techniques: Unraveling the Amyloid Pathogenic Species.
Current pharmaceutical design , 2016 | Pubmed ID: 27189600
A critical concentration of N-terminal pyroglutamylated amyloid beta drives the misfolding of Ab1-42 into more toxic aggregates.
The international journal of biochemistry & cell biology 10, 2016 | Pubmed ID: 27592450
FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-π Interactions.
Cell Apr, 2018 | Pubmed ID: 29677515
Cholesterol catalyses Aβ42 aggregation through a heterogeneous nucleation pathway in the presence of lipid membranes.
Nature chemistry Jun, 2018 | Pubmed ID: 29736006
Determination of Polypeptide Conformation with Nanoscale Resolution in Water.
ACS nano Jul, 2018 | Pubmed ID: 29932670
Identification and nanomechanical characterization of the fundamental single-strand protofilaments of amyloid α-synuclein fibrils.
Proceedings of the National Academy of Sciences of the United States of America 07, 2018 | Pubmed ID: 29941606
Identification of Oxidative Stress in Red Blood Cells with Nanoscale Chemical Resolution by Infrared Nanospectroscopy.
International journal of molecular sciences Aug, 2018 | Pubmed ID: 30200270
Microfluidic deposition for resolving single-molecule protein architecture and heterogeneity.
Nature communications Sep, 2018 | Pubmed ID: 30250131
Atomic force microscopy for single molecule characterisation of protein aggregation.
Archives of biochemistry and biophysics Mar, 2019 | Pubmed ID: 30742801
Fabrication and Characterization of Reconstituted Silk Microgels for the Storage and Release of Small Molecules.
Macromolecular rapid communications Apr, 2019 | Pubmed ID: 30840348
Analysis of αB-crystallin polydispersity in solution through native microfluidic electrophoresis.
The Analyst Jul, 2019 | Pubmed ID: 31215547
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