Department of Clinical Medicine
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A new enzymatic route for production of long 5'-phosphorylated oligonucleotides using suicide cassettes and rolling circle DNA synthesis.
BMC biotechnology Aug, 2007 | Pubmed ID: 17705815
In situ detection of non-polyadenylated RNA molecules using Turtle Probes and target primed rolling circle PRINS.
BMC biotechnology Oct, 2007 | Pubmed ID: 17945012
Detection of short repeated genomic sequences on metaphase chromosomes using padlock probes and target primed rolling circle DNA synthesis.
BMC molecular biology Nov, 2007 | Pubmed ID: 17997865
Single-molecule detection of human topoisomerase I cleavage-ligation activity.
ACS nano Jan, 2009 | Pubmed ID: 19206270
Multiplexed detection of site specific recombinase and DNA topoisomerase activities at the single molecule level.
ACS nano Dec, 2009 | Pubmed ID: 19950974
Strategies for highly sensitive biomarker detection by Rolling Circle Amplification of signals from nucleic acid composed sensors.
Integrative biology : quantitative biosciences from nano to macro Oct, 2011 | Pubmed ID: 21927767
Detection of single enzymatic events in rare or single cells using microfluidics.
ACS nano Oct, 2011 | Pubmed ID: 21936557
Microfluidics-mediated isothermal detection of enzyme activity at the single molecule level.
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference Aug, 2011 | Pubmed ID: 22255034
Droplet microfluidics platform for highly sensitive and quantitative detection of malaria-causing Plasmodium parasites based on enzyme activity measurement.
ACS nano Dec, 2012 | Pubmed ID: 23121492
DNA-based sensor for real-time measurement of the enzymatic activity of human topoisomerase I.
Sensors (Basel, Switzerland) Mar, 2013 | Pubmed ID: 23529147
Real-time detection of TDP1 activity using a fluorophore-quencher coupled DNA-biosensor.
Biosensors & bioelectronics Oct, 2013 | Pubmed ID: 23693093
DNA-based nanosensors for next-generation clinical diagnostics via detection of enzyme activity.
Expert review of molecular diagnostics Jan, 2014 | Pubmed ID: 24308335
Topoisomerase I as a biomarker: detection of activity at the single molecule level.
Sensors (Basel, Switzerland) Jan, 2014 | Pubmed ID: 24434877
Decreased camptothecin sensitivity of the stem-cell-like fraction of Caco2 cells correlates with an altered phosphorylation pattern of topoisomerase I.
PloS one , 2014 | Pubmed ID: 24960044
In-situ hybridization-based quantification of hTR: a possible biomarker in malignant melanoma.
Histopathology Apr, 2015 | Pubmed ID: 25601620
The parental origin correlates with the karyotype of human embryos developing from tripronuclear zygotes.
Clinical and experimental reproductive medicine Mar, 2015 | Pubmed ID: 25874169
Real-time investigation of human topoisomerase I reaction kinetics using an optical sensor: a fast method for drug screening and determination of active enzyme concentrations.
Nanoscale Jun, 2015 | Pubmed ID: 25963854
Correlation between topoisomerase I and tyrosyl-DNA phosphodiesterase 1 activities in non-small cell lung cancer tissue.
Experimental and molecular pathology Aug, 2015 | Pubmed ID: 25987486
Microfluidics-Enabled Enzyme Activity Measurement in Single Cells.
Methods in molecular biology (Clifton, N.J.) , 2015 | Pubmed ID: 26542724
Generation of a double transgenic humanized neonatal Fc receptor (FcRn)/albumin mouse to study the pharmacokinetics of albumin-linked drugs.
Journal of controlled release : official journal of the Controlled Release Society Feb, 2016 | Pubmed ID: 26699424
Molecular characterization of irinotecan (SN-38) resistant human breast cancer cell lines.
BMC cancer Jan, 2016 | Pubmed ID: 26801902
Optimized Detection of Plasmodium falciparum Topoisomerase I Enzyme Activity in a Complex Biological Sample by the Use of Molecular Beacons.
Sensors (Basel, Switzerland) Nov, 2016 | Pubmed ID: 27854277
Novel DNA sensor system for highly sensitive and quantitative retrovirus detection using virus encoded integrase as a biomarker.
Nanoscale Jan, 2017 | Pubmed ID: 27934981
Advantages of an optical nanosensor system for the mechanistic analysis of a novel topoisomerase I targeting drug: a case study.
Nanoscale Feb, 2017 | Pubmed ID: 28094391
The Effects of Dithiothreitol on DNA.
Sensors (Basel, Switzerland) May, 2017 | Pubmed ID: 28538659
Interlinked DNA nano-circles for measuring topoisomerase II activity at the level of single decatenation events.
Nucleic acids research Jul, 2017 | Pubmed ID: 28541438
Quantification of microRNA-21 and microRNA-125b in melanoma tissue.
Melanoma research Oct, 2017 | Pubmed ID: 28614272
On-slide detection of enzymatic activities in selected single cells.
Nanoscale Sep, 2017 | Pubmed ID: 28872165
Characterization of Camptothecin-induced Genomic Changes in the Camptothecin-resistant T-ALL-derived Cell Line CPT-K5.
Cancer genomics & proteomics , 2018 | Pubmed ID: 29496689
Detection of the Malaria causing Plasmodium Parasite in Saliva from Infected Patients using Topoisomerase I Activity as a Biomarker.
Scientific reports Mar, 2018 | Pubmed ID: 29515150
Telomerase reverse transcriptase promoter mutations and solar elastosis in cutaneous melanoma.
Melanoma research Oct, 2018 | Pubmed ID: 29570169
Detection of mRNA of Telomerase Protein in Benign Naevi and Melanomas Using RNAscope.
Applied immunohistochemistry & molecular morphology : AIMM Jan, 2020 | Pubmed ID: 30095463
A new DNA sensor system for specific and quantitative detection of mycobacteria.
Nanoscale Jan, 2019 | Pubmed ID: 30556557
Rapid and Efficient Gene Deletion by CRISPR/Cas9.
Methods in molecular biology (Clifton, N.J.) , 2019 | Pubmed ID: 30912049
Distinguishing recurrence and new primary tumor as well as the origin of neck metastases in head and neck cancer clinical trials by targeted DNA sequencing.
Acta oncologica (Stockholm, Sweden) Oct, 2019 | Pubmed ID: 31271080
Intra-individual variation of circulating tumour DNA in lung cancer patients.
Molecular oncology Oct, 2019 | Pubmed ID: 31306545
Characterization and radiosensitivity of HPV-related oropharyngeal squamous cell carcinoma patient-derived xenografts.
Acta oncologica (Stockholm, Sweden) Oct, 2019 | Pubmed ID: 31510843
Enzymatic activity in single cells.
Methods in enzymology , 2019 | Pubmed ID: 31668235
Topoisomerase I activity and sensitivity to camptothecin in breast cancer-derived cells: a comparative study.
BMC cancer Nov, 2019 | Pubmed ID: 31783818
FcRn overexpression in human cancer drives albumin recycling and cell growth; a mechanistic basis for exploitation in targeted albumin-drug designs.
Journal of controlled release : official journal of the Controlled Release Society Jun, 2020 | Pubmed ID: 32145268
Different Camptothecin Sensitivities in Subpopulations of Colon Cancer Cells Correlate with Expression of Different Phospho-Isoforms of Topoisomerase I with Different Activities.
Cancers May, 2020 | Pubmed ID: 32423158
Targeted next generation sequencing panel for HPV genotyping in cervical cancer.
Experimental and molecular pathology Feb, 2021 | Pubmed ID: 33171155
SNP-based detection of allelic imbalance: A novel approach for identifying KIAA1549-BRAF fusion in pilocytic astrocytoma using DNA sequencing.
Experimental and molecular pathology Jun, 2021 | Pubmed ID: 33626378
Frequently used quantitative polymerase chain reaction-based methods overlook potential clinically relevant genetic alterations in epidermal growth factor receptor compared with next-generation sequencing: a retrospective clinical comparison of 1839 lung adenocarcinomas.
Human pathology Sep, 2021 | Pubmed ID: 34153308
A Dual-Sensor-Based Screening System for In Vitro Selection of TDP1 Inhibitors.
Sensors (Basel, Switzerland) Jul, 2021 | Pubmed ID: 34300575
Simple and Fast DNA Based Sensor System for Screening of Small-Molecule Compounds Targeting Eukaryotic Topoisomerase 1.
Pharmaceutics Aug, 2021 | Pubmed ID: 34452216
TDP1 and TOP1 as targets in anticancer treatment of NSCLC: Activity and protein level in normal and tumor tissue from 150 NSCLC patients correlated to clinical data.
Lung cancer (Amsterdam, Netherlands) Feb, 2022 | Pubmed ID: 34974222
A targeted expression panel for classification, gene fusion detection and PD-L1 measurements - Can molecular profiling replace immunohistochemistry in non-small cell lung cancer?
Experimental and molecular pathology Apr, 2022 | Pubmed ID: 35093316
Targeted Next Generation Sequencing for Human Papillomavirus Genotyping in Cervical Liquid-Based Cytology Samples.
Cancers Jan, 2022 | Pubmed ID: 35158920
Topoisomerase 1 inhibits MYC promoter activity by inducing G-quadruplex formation.
Nucleic acids research Jun, 2022 | Pubmed ID: 35687110
The Diagnostic Value of Circulating Cell-Free HPV DNA in Plasma from Cervical Cancer Patients.
Cells Jul, 2022 | Pubmed ID: 35883612
The psychiatric risk gene BRD1 modulates mitochondrial bioenergetics by transcriptional regulation.
Translational psychiatry Aug, 2022 | Pubmed ID: 35941107
Impact of new molecular criteria on diagnosis and survival of adult glioma patients.
IBRO neuroscience reports Dec, 2022 | Pubmed ID: 36204252
Rolling Circle Enhanced Detection of Specific Restriction Endonuclease Activities in Crude Cell Extracts.
Sensors (Basel, Switzerland) Oct, 2022 | Pubmed ID: 36298113
Prognostic value of mutations, mutations and PD-L1 expression among lung adenocarcinomas treated with immunotherapy.
Journal of clinical pathology Nov, 2022 | Pubmed ID: 36410939
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