Jiahuai Han

Organelle-Directed Metabolic Glycan Labeling and Optical Tracking of Dysfunctional Lysosomes Thereof.

Axin utilizes distinct regions for competitive MEKK1 and MEKK4 binding and JNK activation.

Beta-actin is required for mitochondria clustering and ROS generation in TNF-induced, caspase-independent cell death.

Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation.

Distinct roles of basal steady-state and induced H-ferritin in tumor necrosis factor-induced death in L929 cells.

Frequency and distribution of AP-1 sites in the human genome.

Limiting inflammatory responses during activation of innate immunity.

Nod1-dependent control of tumor growth.

Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia.

Determinants that control the specific interactions between TAB1 and p38alpha.

Differential requirement of MKK4 and MKK7 in JNK activation by distinct scaffold proteins.

The pathways to tumor suppression via route p38.

A beta-catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by aida.

Adenine nucleotide (ADP/ATP) translocase 3 participates in the tumor necrosis factor induced apoptosis of MCF-7 cells.

Determinants that control the distinct subcellular localization of p38alpha-PRAK and p38beta-PRAK complexes.

Impaired microRNA processing causes corpus luteum insufficiency and infertility in mice.

TNF-alpha stimulation inhibits siRNA-mediated RNA interference through a mechanism involving poly-(A) tail stabilization.

[Construction of a novel gene therapy lentiviral vector for drug resistant selection and detection in vivo].

[Screening of highly effective siRNA sequence targeting to HIV-1 vif and the lentiviral-mediated antiviral research in vitro].

Inflammatory signaling and cellular senescence.

p38alpha and p38gamma mediate oncogenic ras-induced senescence through differential mechanisms.

Poly(styrene-alt-maleic anhydride) derivatives as potent anti-HIV microbicide candidates.

Multivalent mannose-displaying nanoparticles constructed from poly{styrene-co-[(maleic anhydride)-alt-styrene]}.

RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis.

Axin determines cell fate by controlling the p53 activation threshold after DNA damage.

Mammalian target of rapamycin regulates murine and human cell differentiation through STAT3/p63/Jagged/Notch cascade.

Distinct effects of p38alpha deletion in myeloid lineage and gut epithelia in mouse models of inflammatory bowel disease.

Specific regulation of noncanonical p38alpha activation by Hsp90-Cdc37 chaperone complex in cardiomyocyte.

Receptor-interacting protein (RIP) kinase family.

Epithelial p38alpha controls immune cell recruitment in the colonic mucosa.

Activation of p38 and determination of its activity.

The miR-17-92 cluster of microRNAs confers tumorigenicity by inhibiting oncogene-induced senescence.

Participation of the p38 pathway in Drosophila host defense against pathogenic bacteria and fungi.

Oxidation-induced intramolecular disulfide bond inactivates mitogen-activated protein kinase kinase 6 by inhibiting ATP binding.

p38γ regulates UV-induced checkpoint signaling and repair of UV-induced DNA damage.

Multiple death pathways in TNF-treated fibroblasts: RIP3- and RIP1-dependent and independent routes.

MAPK signaling in inflammation-associated cancer development.

Inactivation of Rheb by PRAK-mediated phosphorylation is essential for energy-depletion-induced suppression of mTORC1.

MLK4 has negative effect on TLR4 signaling.

Phosphorylation of Raptor by p38beta participates in arsenite-induced mammalian target of rapamycin complex 1 (mTORC1) activation.

Imaging of intracellular acidic compartments with a sensitive rhodamine based fluorogenic pH sensor.

AMPD3 is involved in anthrax LeTx-induced macrophage cell death.

Dual colored mesoporous silica nanoparticles with pH activable rhodamine-lactam for ratiometric sensing of lysosomal acidity.

Chromo-fluorogenic detection of aldehydes with a rhodamine based sensor featuring an intramolecular deoxylactam.

Programmed necrosis: backup to and competitor with apoptosis in the immune system.

A novel function of p38-regulated/activated kinase in endothelial cell migration and tumor angiogenesis.

Determinants of public T cell responses.

GSK3-TIP60-ULK1 signaling pathway links growth factor deprivation to autophagy.

PRAK suppresses oncogenic ras-induced hematopoietic cancer development by antagonizing the JNK pathway.

Efficient inhibition of HIV-1 replication by an artificial polycistronic miRNA construct.

Protein phosphorylation-acetylation cascade connects growth factor deprivation to autophagy.

Recombinatorial biases and convergent recombination determine interindividual TCRβ sharing in murine thymocytes.

Investigation of receptor interacting protein (RIP3)-dependent protein phosphorylation by quantitative phosphoproteomics.

New components of the necroptotic pathway.

The orphan receptor TR3 participates in angiotensin II-induced cardiac hypertrophy by controlling mTOR signalling.

A role of RIP3-mediated macrophage necrosis in atherosclerosis development.

Gene deletion of Gabarap enhances Nlrp3 inflammasome-dependent inflammatory responses.

Diverse sequence determinants control human and mouse receptor interacting protein 3 (RIP3) and mixed lineage kinase domain-like (MLKL) interaction in necroptotic signaling.

A potential suppressive effect of natural antisense IL-1β RNA on lipopolysaccharide-induced IL-1β expression.

Benzothiazoline based chemodosimeters for fluorogenic detection of hypochlorous acid.

Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosis.

The FoxO-BNIP3 axis exerts a unique regulation of mTORC1 and cell survival under energy stress.

Activation of p38α in T cells regulates the intestinal host defense against attaching and effacing bacterial infections.

Rhodamine-propargylic esters for detection of mitochondrial hydrogen sulfide in living cells.

COP1 and GSK3β cooperate to promote c-Jun degradation and inhibit breast cancer cell tumorigenesis.

Recognition of gut microbiota by NOD2 is essential for the homeostasis of intestinal intraepithelial lymphocytes.

The TNF family member 4-1BBL sustains inflammation by interacting with TLR signaling components during late-phase activation.

AMP as a low-energy charge signal autonomously initiates assembly of AXIN-AMPK-LKB1 complex for AMPK activation.

The p38-interacting protein (p38IP) regulates G2/M progression by promoting α-tubulin acetylation via inhibiting ubiquitination-induced degradation of the acetyltransferase GCN5.

Chemokine receptor CX3CR1 contributes to macrophage survival in tumor metastasis.

A near-infrared fluorescence dye for sensitive detection of hydrogen sulfide in serum.

Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway.

Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death.

Dimeric structure of p300/CBP associated factor.

Quantitative phosphoproteomic analysis of RIP3-dependent protein phosphorylation in the course of TNF-induced necroptosis.

HBV life cycle is restricted in mouse hepatocytes expressing human NTCP.

The Gβγ-Src signaling pathway regulates TNF-induced necroptosis via control of necrosome translocation.

pelo is required for high efficiency viral replication.

Regulator of G-protein signaling 19 (RGS19) and its partner Gα-inhibiting activity polypeptide 3 (GNAI3) are required for zVAD-induced autophagy and cell death in L929 cells.

p38 MAPK regulates steroidogenesis through transcriptional repression of STAR gene.

A photothermal cell viability-reporting theranostic nanoprobe for intraoperative optical ablation and tracking of tumors.

The lysosomal v-ATPase-Ragulator complex is a common activator for AMPK and mTORC1, acting as a switch between catabolism and anabolism.

The p38 pathway regulates oxidative stress tolerance by phosphorylation of mitochondrial protein IscU.

Centrifugation aided highly sensitive detection of nitrite with a dye-silica conjugate featuring cleavable linkages.

RNA viruses promote activation of the NLRP3 inflammasome through a RIP1-RIP3-DRP1 signaling pathway.

Cationic nanocarriers induce cell necrosis through impairment of Na(+)/K(+)-ATPase and cause subsequent inflammatory response.

RIP1/RIP3 binding to HSV-1 ICP6 initiates necroptosis to restrict virus propagation in mice.

Ppm1b negatively regulates necroptosis through dephosphorylating Rip3.

Nuclear Export of Smads by RanBP3L Regulates Bone Morphogenetic Protein Signaling and Mesenchymal Stem Cell Differentiation.

A Role for Tubular Necroptosis in Cisplatin-Induced AKI.

Impeding the interaction between Nur77 and p38 reduces LPS-induced inflammation.

Recognition of cytosolic DNA attenuates glucose metabolism and induces AMPK mediated energy stress response.

Lysosomal pH Decrease in Inflammatory Cells Used To Enable Activatable Imaging of Inflammation with a Sialic Acid Conjugated Profluorophore.

ROCK inhibition enhances microRNA function by promoting deadenylation of targeted mRNAs via increasing PAIP2 expression.

Chaperone-mediated autophagy prevents apoptosis by degrading BBC3/PUMA.

TCR-induced sumoylation of the kinase PKC-θ controls T cell synapse organization and T cell activation.

Kinases Mst1 and Mst2 positively regulate phagocytic induction of reactive oxygen species and bactericidal activity.

Group-DIA: analyzing multiple data-independent acquisition mass spectrometry data files.

Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion.

MicroRNA-17~92 inhibits colorectal cancer progression by targeting angiogenesis.

Electrophysiologist shows a cation channel function of MLKL.

The Necrosome in Acute Kidney Injury.

Pyroptosis is driven by non-selective gasdermin-D pore and its morphology is different from MLKL channel-mediated necroptosis.

Repression of MicroRNA Function Mediates Inflammation-associated Colon Tumorigenesis.

p38α has an important role in antigen cross-presentation by dendritic cells.

The MLKL Channel in Necroptosis Is an Octamer Formed by Tetramers in a Dyadic Process.

RIP1 autophosphorylation is promoted by mitochondrial ROS and is essential for RIP3 recruitment into necrosome.

Differential Sensitivity of Target Genes to Translational Repression by miR-17~92.

Responsive hetero-organelle partition conferred fluorogenic sensing of mitochondrial depolarization.

The transcriptional coactivator TAZ regulates reciprocal differentiation of T17 cells and T cells.

2-HG Inhibits Necroptosis by Stimulating DNMT1-Dependent Hypermethylation of the RIP3 Promoter.

The RIP3-RIP1-NF-κB signaling axis is dispensable for necroptotic cells to elicit cross-priming of CD8 T cells.

Defining Cancer Cell Bioenergetic Profiles Using a Dual Organelle-Oriented Chemosensor Responsive to pH Values and Electropotential Changes.

A sialic acid-targeted near-infrared theranostic for signal activation based intraoperative tumor ablation.

A carbohydrate-grafted nanovesicle with activatable optical and acoustic contrasts for dual modality high performance tumor imaging.

Protein kinase D at the Golgi controls NLRP3 inflammasome activation.

Imaging Lysosomal pH Alteration in Stressed Cells with a Sensitive Ratiometric Fluorescence Sensor.

Regulation of Hippo pathway transcription factor TEAD by p38 MAPK-induced cytoplasmic translocation.

Correction for Chen et al., "Nuclear Export of Smads by RanBP3L Regulates Bone Morphogenetic Protein Signaling and Mesenchymal Stem Cell Differentiation".

Plasma membrane changes during programmed cell deaths.

RIP3 targets pyruvate dehydrogenase complex to increase aerobic respiration in TNF-induced necroptosis.

Publisher Correction: The transcriptional coactivator TAZ regulates reciprocal differentiation of T17 cells and T cells.

RIP3 is an upregulator of aerobic metabolism and the enhanced respiration by necrosomal RIP3 feeds back on necrosome to promote necroptosis.

Bioorthogonal Conjugation Directed by a Sugar-Sorting Pathway for Continual Tracking of Stressed Organelles.

miR-30 disrupts senescence and promotes cancer by targeting both p16 and DNA damage pathways.

Redirecting immunity covalently incorporated immunogenic sialic acid on the tumor cell surface.

Author Correction: Regulation of Hippo pathway transcription factor TEAD by p38 MAPK-induced cytoplasmic translocation.

Bifunctional Super-resolution Imaging Probe with Acidity-Independent Lysosome-Retention Mechanism.

Senescence-associated sialidase revealed by an activatable fluorescence-on labeling probe.

Tom20 senses iron-activated ROS signaling to promote melanoma cell pyroptosis.

On the use of abiotic sialic acids to attenuate cell inflammation.

Inactivation of Cyclic AMP Response Element Transcription Caused by Constitutive p38 Activation Is Mediated by Hyperphosphorylation-Dependent CRTC2 Nucleocytoplasmic Transport.

Quantification of Dynamic Protein Interactions and Phosphorylation in LPS Signaling Pathway by SWATH-MS.

Macrophage p38α promotes nutritional steatohepatitis through M1 polarization.

High mobility group box 1 enables bacterial lipids to trigger receptor-interacting protein kinase 3 (RIPK3)-mediated necroptosis and apoptosis in mice.

ZBP1 mediates interferon-induced necroptosis.

An in cellulo-activated multicolor cell labeling approach used to image dying cell clearance.

Efficient engulfment of necroptotic and pyroptotic cells by nonprofessional and professional phagocytes.

Systematic Assessment of the Effect of Internal Library in Targeted Analysis of SWATH-MS.

Organelle-Redirected Chameleon Sensor-Enabled Live Cell Imaging of Mitochondrial DNA.

Bacterial Endotoxin Activates the Coagulation Cascade through Gasdermin D-Dependent Phosphatidylserine Exposure.

Manipulation of Host Cell Death Pathways by Herpes Simplex Virus.

Generation of a murine SWATH-MS spectral library to quantify more than 11,000 proteins.

Gut stem cell necroptosis by genome instability triggers bowel inflammation.

SAMD4 family members suppress human hepatitis B virus by directly binding to the Smaug recognition region of viral RNA.

The p38-interacting protein p38IP suppresses TCR and LPS signaling by targeting TAK1.

Targeting RIPK3 oligomerization blocks necroptosis without inducing apoptosis.

Traceless protein delivery with an efficient recyclable nanocarrier.

A targetable acid-responsive micellar system for signal activation based high performance surgical resolution of tumors.

A fluorescently labelled sialic acid for high performance intraoperative tumor detection.

An overview of mammalian p38 mitogen-activated protein kinases, central regulators of cell stress and receptor signaling.

Erratum to: "Macrophage p38 alpha promotes nutritional steatohepatitis through M1 polarization (J Hepatol 2019; 71(1):163-174)".

A Non-canonical PDK1-RSK Signal Diminishes Pro-caspase-8-Mediated Necroptosis Blockade.

RNA N-Methyladenosine Methyltransferase METTL3 Facilitates Colorectal Cancer by Activating the mA-GLUT1-mTORC1 Axis and Is a Therapeutic Target.

Endogenous Retroelement Activation by Epigenetic Therapy Reverses the Warburg Effect and Elicits Mitochondrial-Mediated Cancer Cell Death.

RIP1-dependent linear and nonlinear recruitments of caspase-8 and RIP3 respectively to necrosome specify distinct cell death outcomes.

An organelle-directed chemical ligation approach enables dual-color detection of mitophagy.

Detection of necroptosis by phospho-MLKL immunohistochemical labeling.

The essential role of PRAK in tumor metastasis and its therapeutic potential.

Installation of high-affinity Siglec-1 ligand on tumor surface for macrophage-engaged tumor suppression.

Pyroptosis of syncytia formed by fusion of SARS-CoV-2 spike and ACE2-expressing cells.

A unique death pathway keeps RIPK1 D325A mutant mice in check at embryonic day 10.5.

Dice-XMBD: Deep Learning-Based Cell Segmentation for Imaging Mass Cytometry.

Glycogen synthase kinase 3 drives thymocyte egress by suppressing β-catenin activation of Akt.

Deep representation features from DreamDIA improve the analysis of data-independent acquisition proteomics.

NLRC4 inflammasome-dependent cell death occurs by a complementary series of three death pathways and determines lethality in mice.

synthesis of dendrimeric sensors for fluorescence-on imaging of bacterial phagocytosis.

Gasdermin E mediates photoreceptor damage by all-trans-retinal in the mouse retina.

MSSort-DIA: A deep learning classification tool of the peptide precursors quantified by OpenSWATH.

Mosaic composition of RIP1-RIP3 signalling hub and its role in regulating cell death.

Dual ligand engagement for noncanonical inflammasome activation.

DAISM-DNN: Highly accurate cell type proportion estimation with data augmentation and deep neural networks.

Biocapture-Directed Chemical Labeling for Discerning Stressed States of Organelles.

Immunostaining of phospho-RIPK3 in L929 cells, murine yolk sacs, ceca, and small intestines.

Protocol to estimate cell type proportions from bulk RNA-seq using DAISM-DNN.

Rethinking sepsis after a two-year battle with COVID-19.

A p38α-BLIMP1 signalling pathway is essential for plasma cell differentiation.

Sensitive imaging of Endoplasmic reticulum (ER) autophagy with an acidity-reporting ER-Tracker.

Ribosome-rescuer PELO catalyzes the oligomeric assembly of NOD-like receptor family proteins via activating their ATPase enzymatic activity.

Dear-DIA: Deep Autoencoder Enables Deconvolution of Data-Independent Acquisition Proteomics.

Fluorescence-On Imaging of Reticulophagy Enabled by an Acidity-Reporting Solvatochromic Probe.

Protocol for reconstitution of oligomeric assembly of NAIP5-NLRC4 inflammasome in vitro.

Anthrax lethal toxin and tumor necrosis factor-α synergize on intestinal epithelia to induce mouse death.

Optimal tagging strategies for illuminating expression profiles of genes with different abundance in zebrafish.

COVID-19 vaccines and beyond.

Bypassing PELO-mediated ATPase activation of the NLR is a common pathogenic cause of NLR-associated autoinflammatory diseases.

Phosphorylation of caspase-8 by RSKs via organ-constrained effects controls the sensitivity to TNF-induced death.

Signal-Sustained Imaging of Mitophagy with an Enzyme-Activatable Metabolic Lipid Labeling Probe.

Author Correction: RIP3 targets pyruvate dehydrogenase complex to increase aerobic respiration in TNF-induced necroptosis.

AMPK targets PDZD8 to trigger carbon source shift from glucose to glutamine.

ZBTB21 suppresses CRE-mediated transcription to impair synaptic function in Down syndrome.

Lymphatic-localized Treg-mregDC crosstalk limits antigen trafficking and restrains anti-tumor immunity.

Cecal necroptosis triggers lethal cardiac dysfunction in TNF-induced severe SIRS.

Dear-PSM: A deep learning-based peptide search engine enables full database search for proteomics.

Residue Y362 is crucial for FLIP to impart catalytic activity to pro-caspase-8 to suppress necroptosis.

A GSDMD agonist boosts specific antitumor immunity.

p38α-eIF6-Nsun2 axis promotes ILC3's rapid response to protect host from intestinal inflammation.