Department of Bioengineering,
Department of Mechanical & Industrial Engineering
Ambika Bajpayee is an Assistant Professor in the Department of Bioengineering at Northeastern University and heads the Molecular Bioelectrostatics and Drug Delivery Lab. Her interests include targeted drug delivery, bio-electrostatics, cell derived exosomes, peptide and protein-based nanocarriers, and modeling of bio-transport and biomechanics. Ambika received her PhD in Mechanical Engineering at Massachusetts Institute of Technology (MIT) and also completed her post-doctoral work there focused on developing devices for oral drug delivery to the gastrointestinal tract and investigating disease-related changes in mechanics and permeability of mucosal membranes. Previously, she worked as a medical device engineer on development and FDA approval of orthopedic and dental implants. Ambika is a recipient of the US Department of Defense Discovery Award, National Institute of Health Trailblazer Award, MIT Women of Excellence and Meredith Kamm Memorial Award in Mechanical Engineering. Her laboratory is also funded by other NIH translational awards and the pharmaceutical industry, and works towards bridging the gap between basic science and clinical technologies. She holds a Masters degree from MIT and an undergraduate degree from the University of Delhi, India. Outside of the lab, Ambika loves to spend time with her one-year old new boss, oil paint, play chess, cook and travel to faraway lands.
Cartilage-targeting drug delivery: can electrostatic interactions help?
Nature reviews. Rheumatology Mar, 2017 | Pubmed ID: 28202920
Sustained intra-cartilage delivery of low dose dexamethasone using a cationic carrier for treatment of post traumatic osteoarthritis.
European cells & materials 12, 2017 | Pubmed ID: 29205258
Multi-scale imaging techniques to investigate solute transport across articular cartilage.
Journal of biomechanics 09, 2018 | Pubmed ID: 30093067
Cartilage penetrating cationic peptide carriers for applications in drug delivery to avascular negatively charged tissues.
Acta biomaterialia 07, 2019 | Pubmed ID: 30529083
Interleukin-1 receptor antagonist (IL-1Ra) is more effective in suppressing cytokine-induced catabolism in cartilage-synovium co-culture than in cartilage monoculture.
Arthritis research & therapy 11, 2019 | Pubmed ID: 31722745
Multi-arm Avidin nano-construct for intra-cartilage delivery of small molecule drugs.
Journal of controlled release : official journal of the Controlled Release Society 02, 2020 | Pubmed ID: 31843642
Avidin-biotin technology to synthesize multi-arm nano-construct for drug delivery.
MethodsX , 2020 | Pubmed ID: 32405463
Avidin grafted dextran nanostructure enables a month-long intra-discal retention.
Scientific reports Jul, 2020 | Pubmed ID: 32694557
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