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The disease modifying osteoarthritis drug (DMOAD): Is it in the horizon?
Pharmacological research Jul, 2008 | Pubmed ID: 18590824
Biochemical markers of joint tissue turnover.
Assay and drug development technologies Feb, 2010 | Pubmed ID: 19715454
Which elements are involved in reversible and irreversible cartilage degradation in osteoarthritis?
Rheumatology international Feb, 2010 | Pubmed ID: 19816688
Suppression of MMP activity in bovine cartilage explants cultures has little if any effect on the release of aggrecanase-derived aggrecan fragments.
BMC research notes Dec, 2009 | Pubmed ID: 20021645
Aggrecanase- and matrix metalloproteinase-mediated aggrecan degradation is associated with different molecular characteristics of aggrecan and separated in time ex vivo.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals May, 2010 | Pubmed ID: 20039789
Application of biochemical markers in development of drugs for treatment of osteoarthritis.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals Feb, 2010 | Pubmed ID: 20085489
Serum markers of liver fibrosis: combining the BIPED classification and the neo-epitope approach in the development of new biomarkers.
Disease markers , 2010 | Pubmed ID: 20164543
Procollagen type I N-terminal propeptide (PINP) is a marker for fibrogenesis in bile duct ligation-induced fibrosis in rats.
Fibrogenesis & tissue repair Apr, 2010 | Pubmed ID: 20359335
Investigation of the direct effects of salmon calcitonin on human osteoarthritic chondrocytes.
BMC musculoskeletal disorders Apr, 2010 | Pubmed ID: 20367884
Novel combinations of Post-Translational Modification (PTM) neo-epitopes provide tissue-specific biochemical markers--are they the cause or the consequence of the disease?
Clinical biochemistry Jul, 2010 | Pubmed ID: 20381482
Oral salmon calcitonin--pharmacology in osteoporosis.
Expert opinion on biological therapy Nov, 2010 | Pubmed ID: 20932224
Enzyme-linked immunosorbent assay (ELISAs) for metalloproteinase derived type II collagen neoepitope, CIIM--increased serum CIIM in subjects with severe radiographic osteoarthritis.
Clinical biochemistry Apr, 2011 | Pubmed ID: 21223960
Measurement of matrix metalloproteinase 9-mediated collagen type III degradation fragment as a marker of skin fibrosis.
BMC dermatology Mar, 2011 | Pubmed ID: 21447148
Biochemical markers of ongoing joint damage in rheumatoid arthritis--current and future applications, limitations and opportunities.
Arthritis research & therapy Apr, 2011 | Pubmed ID: 21539724
Glucocorticoids exert context-dependent effects on cells of the joint in vitro.
Steroids Dec, 2011 | Pubmed ID: 21855558
Molecular serum and urine marker repertoire supporting clinical research on joint diseases.
Best practice & research. Clinical rheumatology Dec, 2011 | Pubmed ID: 22265266
Investigation of chondrocyte hypertrophy and cartilage calcification in a full-depth articular cartilage explants model.
Rheumatology international Feb, 2013 | Pubmed ID: 22453523
The inhibitory effect of salmon calcitonin on tri-iodothyronine induction of early hypertrophy in articular cartilage.
PloS one , 2012 | Pubmed ID: 22768225
Extracellular matrix remodeling: the common denominator in connective tissue diseases. Possibilities for evaluation and current understanding of the matrix as more than a passive architecture, but a key player in tissue failure.
Assay and drug development technologies Mar, 2013 | Pubmed ID: 23046407
Future detection and monitoring of diabetes may entail analysis of both β-cell function and volume: how markers of β-cell loss may assist.
Journal of translational medicine Oct, 2012 | Pubmed ID: 23110768
Quantification of "end products" of tissue destruction in inflammation may reflect convergence of cytokine and signaling pathways -- implications for modern clinical chemistry.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals Aug, 2013 | Pubmed ID: 23721060
Extracellular matrix specific protein fingerprints measured in serum can separate pancreatic cancer patients from healthy controls.
BMC cancer Nov, 2013 | Pubmed ID: 24261855
Rheumatoid arthritis: a case for personalized health care?
Arthritis care & research Sep, 2014 | Pubmed ID: 24470057
The active form of MMP-3 is a marker of synovial inflammation and cartilage turnover in inflammatory joint diseases.
BMC musculoskeletal disorders Mar, 2014 | Pubmed ID: 24641725
Serum biomarkers reflecting specific tumor tissue remodeling processes are valuable diagnostic tools for lung cancer.
Cancer medicine Oct, 2014 | Pubmed ID: 25044252
Cartilage turnover reflected by metabolic processing of type II collagen: a novel marker of anabolic function in chondrocytes.
International journal of molecular sciences Oct, 2014 | Pubmed ID: 25329619
Novel insights into the function and dynamics of extracellular matrix in liver fibrosis.
American journal of physiology. Gastrointestinal and liver physiology May, 2015 | Pubmed ID: 25767261
Clinical Drug Development Using Dynamic Biomarkers to Enable Personalized Health Care in COPD.
Chest Jul, 2015 | Pubmed ID: 25856563
Diagnosis of Osteoarthritis by Cartilage Surface Smoothness Quantified Automatically from Knee MRI.
Cartilage Jan, 2011 | Pubmed ID: 26069569
Characterization of an Ex vivo Femoral Head Model Assessed by Markers of Bone and Cartilage Turnover.
Cartilage Jul, 2011 | Pubmed ID: 26069585
Fragments of Citrullinated and MMP-degraded Vimentin and MMP-degraded Type III Collagen Are Novel Serological Biomarkers to Differentiate Crohn's Disease from Ulcerative Colitis.
Journal of Crohn's & colitis Oct, 2015 | Pubmed ID: 26188349
Serum cartilage oligomeric matrix protein and development of radiographic and painful knee osteoarthritis. A community-based cohort of middle-aged women.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals , 2015 | Pubmed ID: 26848781
Synovitis biomarkers: ex vivo characterization of three biomarkers for identification of inflammatory osteoarthritis.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals , 2015 | Pubmed ID: 26863055
Neo-Epitopes--Fragments of Cartilage and Connective Tissue Degradation in Early Rheumatoid Arthritis and Unclassified Arthritis.
PloS one , 2016 | Pubmed ID: 27019199
Intercritical circulating levels of neo-epitopes reflecting matrixmetalloprotease-driven degradation as markers of gout and frequent gout attacks.
Rheumatology (Oxford, England) 09, 2016 | Pubmed ID: 27256715
Chondrocyte activity is increased in psoriatic arthritis and axial spondyloarthritis.
Arthritis research & therapy 06, 2016 | Pubmed ID: 27306080
Remodeling of the Tumor Microenvironment Predicts Increased Risk of Cancer in Postmenopausal Women: The Prospective Epidemiologic Risk Factor (PERF I) Study.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 09, 2016 | Pubmed ID: 27411352
Type I and III collagen turnover is increased in axial spondyloarthritis and psoriatic arthritis. Associations with disease activity and diagnostic capacity.
Clinical and experimental rheumatology Jul-Aug, 2017 | Pubmed ID: 28240584
Nidogen-1 Degraded by Cathepsin S can be Quantified in Serum and is Associated with Non-Small Cell Lung Cancer.
Neoplasia (New York, N.Y.) 04, 2017 | Pubmed ID: 28282545
Biomarker of extracellular matrix remodelling C1M and proinflammatory cytokine interleukin 6 are related to synovitis and pain in end-stage knee osteoarthritis patients.
Pain 07, 2017 | Pubmed ID: 28333699
Unique insight into microenvironmental changes in colorectal cancer: assessment of matrix metalloprotease-mediated molecular changes in human colorectal tumor tissue and corresponding non-neoplastic adjacent tissue.
Oncology letters May, 2017 | Pubmed ID: 28529592
Suppression of active, but not total MMP-3, is associated with treatment response in a phase III clinical study of rheumatoid arthritis.
Clinical and experimental rheumatology Jan-Feb, 2018 | Pubmed ID: 28850021
Changes of patient-reported outcomes and protein fingerprint biomarkers after exercise therapy for axial spondyloarthritis.
Clinical rheumatology Jan, 2019 | Pubmed ID: 28856518
Excessive matrix metalloprotease-mediated degradation of interstitial tissue (type I collagen) independently predicts short-term survival in an observational study of postmenopausal women diagnosed with cancer.
Oncotarget Aug, 2017 | Pubmed ID: 28881747
Ulcerative colitis, Crohn's disease, and irritable bowel syndrome have different profiles of extracellular matrix turnover, which also reflects disease activity in Crohn's disease.
PloS one , 2017 | Pubmed ID: 29028807
Biochemical marker discovery, testing and evaluation for facilitating OA drug discovery and development.
Drug discovery today 02, 2018 | Pubmed ID: 29038075
Blockade of GM-CSF pathway induced sustained suppression of myeloid and T cell activities in rheumatoid arthritis.
Rheumatology (Oxford, England) 01, 2018 | Pubmed ID: 29069507
Sprifermin (rhFGF18) modulates extracellular matrix turnover in cartilage explants ex vivo.
Journal of translational medicine Dec, 2017 | Pubmed ID: 29233174
Identification of pain categories associated with change in pain in patients receiving placebo: data from two phase 3 randomized clinical trials in symptomatic knee osteoarthritis.
BMC musculoskeletal disorders 01, 2018 | Pubmed ID: 29343266
IL-6 receptor inhibition modulates type III collagen and C-reactive protein degradation in rheumatoid arthritis patients with an inadequate response to anti-tumour necrosis factor therapy: analysis of connective tissue turnover in the tocilizumab RADIATE study.
Clinical and experimental rheumatology Jul-Aug, 2018 | Pubmed ID: 29465346
Increased remodelling of interstitial collagens and basement membrane is suppressed by treatment in patients with rheumatoid arthritis: serological evaluation of a one-year prospective study of 149 Japanese patients.
Clinical and experimental rheumatology May-Jun, 2018 | Pubmed ID: 29465351
Aggrecanase degradation of type III collagen is associated with clinical knee pain.
Clinical biochemistry Aug, 2018 | Pubmed ID: 29702061
Protein biomarkers associated with pain mechanisms in osteoarthritis.
Journal of proteomics 01, 2019 | Pubmed ID: 29704569
Type IV collagen metabolism is associated with disease activity, radiographic progression and response to tocilizumab in rheumatoid arthritis.
Clinical and experimental rheumatology Sep-Oct, 2018 | Pubmed ID: 29745884
Bone and Soft Tissue Turnover in Relation to All-cause Mortality in Postmenopausal Women.
The journals of gerontology. Series A, Biological sciences and medical sciences Jun, 2019 | Pubmed ID: 30010805
Tofacitinib and TPCA-1 exert chondroprotective effects on extracellular matrix turnover in bovine articular cartilage ex vivo.
Biochemical pharmacology Jul, 2019 | Pubmed ID: 30059674
A Novel High Sensitivity Type II Collagen Blood-Based Biomarker, PRO-C2, for Assessment of Cartilage Formation.
International journal of molecular sciences Nov, 2018 | Pubmed ID: 30404167
The VICM biomarker is released from activated macrophages and inhibited by anti-GM-CSFRα-mAb treatment in rheumatoid arthritis patients.
Clinical and experimental rheumatology Jan-Feb, 2019 | Pubmed ID: 30418117
Molecular taxonomy of osteoarthritis for patient stratification, disease management and drug development: biochemical markers associated with emerging clinical phenotypes and molecular endotypes.
Current opinion in rheumatology 01, 2019 | Pubmed ID: 30461544
Serum biomarkers of collagen turnover as potential diagnostic tools in diffuse systemic sclerosis: A cross-sectional study.
PloS one , 2018 | Pubmed ID: 30507931
Soluble biochemical markers of osteoarthritis: Are we close to using them in clinical practice?
Best practice & research. Clinical rheumatology 10, 2017 | Pubmed ID: 30509415
Osteoarthritis year in review 2018: biomarkers (biochemical markers).
Osteoarthritis and cartilage Mar, 2019 | Pubmed ID: 30552966
Serological biomarker profiles of rapidly progressive osteoarthritis in tanezumab-treated patients.
Osteoarthritis and cartilage Mar, 2019 | Pubmed ID: 30576794
Metabolites of C-reactive protein and vimentin are associated with disease activity of axial spondyloarthritis.
Clinical and experimental rheumatology May-Jun, 2019 | Pubmed ID: 30767876
GPDPLQ-A Type II Collagen Neo-Epitope Biomarker of Osteoclast- and Inflammation-Derived Cartilage Degradation in vitro.
Scientific reports Feb, 2019 | Pubmed ID: 30816326
Association of metabolites reflecting type III and VI collagen formation with modified Rodnan skin score in systemic sclerosis - a cross-sectional study.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals Jun, 2019 | Pubmed ID: 30821519
Osteoarthritis phenotypes and novel therapeutic targets.
Biochemical pharmacology Jul, 2019 | Pubmed ID: 30831073
Serological Assessment of the Quality of Wound Healing Processes in Crohn's Disease.
Journal of gastrointestinal and liver diseases : JGLD Jun, 2019 | Pubmed ID: 31204415
Associations between biomarkers of bone and cartilage turnover, gender, pain categories and radiographic severity in knee osteoarthritis.
Arthritis research & therapy Sep, 2019 | Pubmed ID: 31481084
Biochemical markers in osteoarthritis with lessons learned from osteoporosis.
Clinical and experimental rheumatology Sep-Oct, 2019 | Pubmed ID: 31621570
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