Theodor Kocher Institute
Britta Engelhardt is Professor for Immunobiology and the Director of the Theodor Kocher Institute at the University of Bern in Switzerland. She has obtained a degree in Human Biology from the Philipps-University, Marburg in Germany in 1987. She performed her PhD thesis in the laboratory of Hartmut Wekerle (Max-Planck Clinical Research Group for Multiple Sclerosis, Würzburg and Max- Planck Institute for Psychiatry, Martinsried, Germany) and obtained a PhD in Human Biology (Dr. rer. physiol.) in January 1991. After a post-doctoral fellowship in the laboratory of Eugene C. Butcher at Stanford University, California, she set up her own research group at the Max- Planck Institute for Physiological and Clinical Research, Bad Nauheim, Germany in the department of Werner Risau (†December 13th, 1998) in 1993. In 1998 she obtained the Venia Legendi for Immunology and Cell Biology from the Medical Faculty of the Philipps University Marburg, Germany. From 1999 to 2003 she headed her research group as a senior group leader at the same institute and the Max-Planck-Institute for Vascular Cell Biology (Director Dietmar Vestweber) in Münster, Germany. In 2003 she accepted the call as Full Professor from the University of Bern.
Britta Engelhardt is an expert in brain barriers biology and her research is dedicated to understanding the role of the brain barriers in maintaining central nervous system (CNS) immune privilege. Using advanced in vitro and in vivo live cell imaging approaches her laboratory has significantly contributed to the current understanding of the anatomical routes and molecular mechansism used by immune cells to enter the CNS during immune surveillance and neuroinflammation in the context of multiple sclerosis and ischemic stoke. She regularly presents her findings and concepts as invited speaker and keynote speaker at international meetings.
Britta Engelhardt has served the scientific community by coordinating several national (Singergia UnmetMS, ProDocCellMigration) and international collaborative networks (JUSTBRIN, BtRAIN) dedicated to brain barriers research and neuroinflammation. She was elected Vice-Chair and Chair of the Gordon Research Conference Barriers of the CNS in 2016 and 2018, respectively and is the president of the Swiss Society for Microcirculation and Vascular Research (SSMVR).
Mini-review: Transendothelial migration of leukocytes: through the front door or around the side of the house?
European journal of immunology Nov, 2004 | Pubmed ID: 15376193
P-selectin glycoprotein ligand 1 is not required for the development of experimental autoimmune encephalomyelitis in SJL and C57BL/6 mice.
Journal of immunology (Baltimore, Md. : 1950) Jul, 2005 | Pubmed ID: 16002731
The ins and outs of T-lymphocyte trafficking to the CNS: anatomical sites and molecular mechanisms.
Trends in immunology Sep, 2005 | Pubmed ID: 16039904
VE-PTP maintains the endothelial barrier via plakoglobin and becomes dissociated from VE-cadherin by leukocytes and by VEGF.
The Journal of experimental medicine Nov, 2008 | Pubmed ID: 19015309
Beta1 integrins differentially control extravasation of inflammatory cell subsets into the CNS during autoimmunity.
Proceedings of the National Academy of Sciences of the United States of America Feb, 2009 | Pubmed ID: 19179279
Endothelial cell activation leads to neutrophil transmigration as supported by the sequential roles of ICAM-2, JAM-A, and PECAM-1.
Blood Jun, 2009 | Pubmed ID: 19211506
Lack of junctional adhesion molecule (JAM)-B ameliorates experimental autoimmune encephalomyelitis.
Brain, behavior, and immunity Oct, 2018 | Pubmed ID: 29920328
Claudin-3-deficient C57BL/6J mice display intact brain barriers.
Scientific reports Jan, 2019 | Pubmed ID: 30659216
The Genetic Background of Mice Influences the Effects of Cigarette Smoke on Onset and Severity of Experimental Autoimmune Encephalomyelitis.
International journal of molecular sciences Mar, 2019 | Pubmed ID: 30901861
Gene and protein expression profiling of the microvascular compartment in experimental autoimmune encephalomyelitis in C57Bl/6 and SJL mice.
Brain pathology (Zurich, Switzerland) Jan, 2005 | Pubmed ID: 15779231
Importance of integrin LFA-1 deactivation for the generation of immune responses.
The Journal of experimental medicine Jun, 2005 | Pubmed ID: 15955836
Therapeutic targeting of alpha 4-integrins in chronic inflammatory diseases: tipping the scales of risk towards benefit?
European journal of immunology Aug, 2005 | Pubmed ID: 16052610
The circumventricular organs participate in the immunopathogenesis of experimental autoimmune encephalomyelitis.
Cerebrospinal fluid research Sep, 2005 | Pubmed ID: 16197544
Regulation of immune cell entry into the central nervous system.
Results and problems in cell differentiation , 2006 | Pubmed ID: 17068976
E- and P-selectin are not required for the development of experimental autoimmune encephalomyelitis in C57BL/6 and SJL mice.
Journal of immunology (Baltimore, Md. : 1950) Dec, 2007 | Pubmed ID: 18056394
Natalizumab: targeting alpha4-integrins in multiple sclerosis.
Neuro-degenerative diseases , 2008 | Pubmed ID: 18075270
Therapeutic targeting of leukocyte trafficking across the blood-brain barrier.
Inflammation & allergy drug targets Dec, 2007 | Pubmed ID: 18220956
Inducible endothelial cell-specific gene expression in transgenic mouse embryos and adult mice.
Experimental cell research Apr, 2008 | Pubmed ID: 18272150
Effect of interferon-beta and atorvastatin on Th1/Th2 cytokines in multiple sclerosis.
Neurochemistry international Jul, 2008 | Pubmed ID: 18524417
Immune cell entry into the central nervous system: involvement of adhesion molecules and chemokines.
Journal of the neurological sciences Nov, 2008 | Pubmed ID: 18573502
Distinct molecular composition of blood and lymphatic vascular endothelial cell junctions establishes specific functional barriers within the peripheral lymph node.
European journal of immunology Aug, 2008 | Pubmed ID: 18629939
L-Selectin-deficient SJL and C57BL/6 mice are not resistant to experimental autoimmune encephalomyelitis.
European journal of immunology Aug, 2008 | Pubmed ID: 18651702
The blood-central nervous system barriers actively control immune cell entry into the central nervous system.
Current pharmaceutical design , 2008 | Pubmed ID: 18673197
Flotillins interact with PSGL-1 in neutrophils and, upon stimulation, rapidly organize into membrane domains subsequently accumulating in the uropod.
PloS one , 2009 | Pubmed ID: 19404397
Cutting edge: Natalizumab blocks adhesion but not initial contact of human T cells to the blood-brain barrier in vivo in an animal model of multiple sclerosis.
Journal of immunology (Baltimore, Md. : 1950) May, 2009 | Pubmed ID: 19414741
Culture-induced changes in blood-brain barrier transcriptome: implications for amino-acid transporters in vivo.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Sep, 2009 | Pubmed ID: 19491922
The blood-brain and the blood-cerebrospinal fluid barriers: function and dysfunction.
Seminars in immunopathology Nov, 2009 | Pubmed ID: 19779720
Preclinical testing of strategies for therapeutic targeting of human T-cell trafficking in vivo.
Methods in molecular biology (Clifton, N.J.) , 2010 | Pubmed ID: 20379881
Comprehensive analysis of lymph node stroma-expressed Ig superfamily members reveals redundant and nonredundant roles for ICAM-1, ICAM-2, and VCAM-1 in lymphocyte homing.
Blood Aug, 2010 | Pubmed ID: 20395417
Alpha4beta1 integrin mediates the recruitment of immature dendritic cells across the blood-brain barrier during experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950) Jun, 2010 | Pubmed ID: 20483748
Comparison of immortalized bEnd5 and primary mouse brain microvascular endothelial cells as in vitro blood-brain barrier models for the study of T cell extravasation.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Jan, 2011 | Pubmed ID: 20606687
Differential roles for endothelial ICAM-1, ICAM-2, and VCAM-1 in shear-resistant T cell arrest, polarization, and directed crawling on blood-brain barrier endothelium.
Journal of immunology (Baltimore, Md. : 1950) Oct, 2010 | Pubmed ID: 20861356
PSGL-1 is dispensible for the development of active experimental autoimmune encephalomyelitis in SJL/J mice.
Journal of neuroimmunology Mar, 2011 | Pubmed ID: 21051092
Tight junctions in brain barriers during central nervous system inflammation.
Antioxidants & redox signaling Sep, 2011 | Pubmed ID: 21338320
TET inducible expression of the α4β7-integrin ligand MAdCAM-1 on the blood-brain barrier does not influence the immunopathogenesis of experimental autoimmune encephalomyelitis.
European journal of immunology Mar, 2011 | Pubmed ID: 21341265
Fluids and barriers of the CNS establish immune privilege by confining immune surveillance to a two-walled castle moat surrounding the CNS castle.
Fluids and barriers of the CNS Jan, 2011 | Pubmed ID: 21349152
Brain infiltration of leukocytes contributes to the pathophysiology of temporal lobe epilepsy.
The Journal of neuroscience : the official journal of the Society for Neuroscience Mar, 2011 | Pubmed ID: 21411646
β1-integrin/matrix interactions support blood-brain barrier integrity.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Oct, 2011 | Pubmed ID: 21772311
Claudin-1 induced sealing of blood-brain barrier tight junctions ameliorates chronic experimental autoimmune encephalomyelitis.
Acta neuropathologica Nov, 2011 | Pubmed ID: 21983942
Neuroscience. Blood-brain barrier differentiation.
Science (New York, N.Y.) Dec, 2011 | Pubmed ID: 22194564
Loss of astrocyte polarization upon transient focal brain ischemia as a possible mechanism to counteract early edema formation.
Glia Nov, 2012 | Pubmed ID: 22782669
Capture, crawl, cross: the T cell code to breach the blood-brain barriers.
Trends in immunology Dec, 2012 | Pubmed ID: 22926201
Going against the tide--how encephalitogenic T cells breach the blood-brain barrier.
Journal of vascular research , 2012 | Pubmed ID: 22948545
Junctional adhesion molecule (JAM)-C deficient C57BL/6 mice develop a severe hydrocephalus.
PloS one , 2012 | Pubmed ID: 23029139
Immunologic privilege in the central nervous system and the blood-brain barrier.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Jan, 2013 | Pubmed ID: 23072749
The neurovascular unit as a selective barrier to polymorphonuclear granulocyte (PMN) infiltration into the brain after ischemic injury.
Acta neuropathologica Mar, 2013 | Pubmed ID: 23269317
Live cell imaging techniques to study T cell trafficking across the blood-brain barrier in vitro and in vivo.
Fluids and barriers of the CNS Jan, 2013 | Pubmed ID: 23336847
Wnt activation of immortalized brain endothelial cells as a tool for generating a standardized model of the blood brain barrier in vitro.
PloS one , 2013 | Pubmed ID: 23940549
Kindlin-3 regulates integrin activation and adhesion reinforcement of effector T cells.
Proceedings of the National Academy of Sciences of the United States of America Oct, 2013 | Pubmed ID: 24089451
β2 integrin-mediated crawling on endothelial ICAM-1 and ICAM-2 is a prerequisite for transcellular neutrophil diapedesis across the inflamed blood-brain barrier.
Journal of immunology (Baltimore, Md. : 1950) Jan, 2014 | Pubmed ID: 24259506
Novel insights into the development and maintenance of the blood-brain barrier.
Cell and tissue research Mar, 2014 | Pubmed ID: 24590145
DARC shuttles inflammatory chemokines across the blood-brain barrier during autoimmune central nervous system inflammation.
Brain : a journal of neurology May, 2014 | Pubmed ID: 24625696
PSGL-1 and E/P-selectins are essential for T-cell rolling in inflamed CNS microvessels but dispensable for initiation of EAE.
European journal of immunology Aug, 2014 | Pubmed ID: 24740164
Novel oxazolo-oxazole derivatives of FTY720 reduce endothelial cell permeability, immune cell chemotaxis and symptoms of experimental autoimmune encephalomyelitis in mice.
Neuropharmacology Oct, 2014 | Pubmed ID: 24863045
A stable and reproducible human blood-brain barrier model derived from hematopoietic stem cells.
PloS one , 2014 | Pubmed ID: 24936790
Neutrophils mediate blood-spinal cord barrier disruption in demyelinating neuroinflammatory diseases.
Journal of immunology (Baltimore, Md. : 1950) Sep, 2014 | Pubmed ID: 25049355
The heparan sulfate proteoglycan agrin contributes to barrier properties of mouse brain endothelial cells by stabilizing adherens junctions.
Cell and tissue research Nov, 2014 | Pubmed ID: 25107608
Cell surface levels of endothelial ICAM-1 influence the transcellular or paracellular T-cell diapedesis across the blood-brain barrier.
European journal of immunology Apr, 2015 | Pubmed ID: 25545837
Investigation of leptomeningeal enhancement in MS: a postcontrast FLAIR MRI study.
Neurology Feb, 2015 | Pubmed ID: 25616480
Mode of action of claudin peptidomimetics in the transient opening of cellular tight junction barriers.
Biomaterials Jun, 2015 | Pubmed ID: 25907035
Brain barriers: Crosstalk between complex tight junctions and adherens junctions.
The Journal of cell biology May, 2015 | Pubmed ID: 26008742
Wiring the Vascular Network with Neural Cues: A CNS Perspective.
Neuron Jul, 2015 | Pubmed ID: 26182414
Migration of encephalitogenic CD8 T cells into the central nervous system is dependent on the α4β1-integrin.
European journal of immunology Dec, 2015 | Pubmed ID: 26358409
Inhibition and deficiency of the immunoproteasome subunit LMP7 attenuates LCMV-induced meningitis.
European journal of immunology Jan, 2016 | Pubmed ID: 26464284
Leptomeningeal contrast enhancement and blood-CSF barrier dysfunction in aseptic meningitis.
Neurology(R) neuroimmunology & neuroinflammation Dec, 2015 | Pubmed ID: 26516629
Immune cell trafficking across the barriers of the central nervous system in multiple sclerosis and stroke.
Biochimica et biophysica acta Mar, 2016 | Pubmed ID: 26527183
Sphingosine kinase 2 deficient mice exhibit reduced experimental autoimmune encephalomyelitis: Resistance to FTY720 but not ST-968 treatments.
Neuropharmacology Jun, 2016 | Pubmed ID: 26808312
Lung ICAM-1 and ICAM-2 support spontaneous intravascular effector lymphocyte entrapment but are not required for neutrophil entrapment or emigration inside endotoxin-inflamed lungs.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology May, 2016 | Pubmed ID: 26823454
Modeling immune functions of the mouse blood-cerebrospinal fluid barrier in vitro: primary rather than immortalized mouse choroid plexus epithelial cells are suited to study immune cell migration across this brain barrier.
Fluids and barriers of the CNS Jan, 2016 | Pubmed ID: 26833402
Postarrest stalling rather than crawling favors CD8(+) over CD4(+) T-cell migration across the blood-brain barrier under flow in vitro.
European journal of immunology Sep, 2016 | Pubmed ID: 27338806
Current multiple sclerosis treatments have improved our understanding of MS autoimmune pathogenesis.
European journal of immunology Sep, 2016 | Pubmed ID: 27467894
Refined clinical scoring in comparative EAE studies does not enhance the chance to observe statistically significant differences.
European journal of immunology 10, 2016 | Pubmed ID: 27469626
Vascular, glial, and lymphatic immune gateways of the central nervous system.
Acta neuropathologica Sep, 2016 | Pubmed ID: 27522506
Neutrophil recruitment limited by high-affinity bent β2 integrin binding ligand in cis.
Nature communications Aug, 2016 | Pubmed ID: 27578049
Non-invasive near-infrared fluorescence imaging of the neutrophil response in a mouse model of transient cerebral ischaemia.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Aug, 2017 | Pubmed ID: 27789786
Dual role of ALCAM in neuroinflammation and blood-brain barrier homeostasis.
Proceedings of the National Academy of Sciences of the United States of America Jan, 2017 | Pubmed ID: 28069965
The movers and shapers in immune privilege of the CNS.
Nature immunology Feb, 2017 | Pubmed ID: 28092374
How Does the Immune System Enter the Brain?
Frontiers in immunology , 2022 | Pubmed ID: 35273596
ALCAM (CD166) is involved in extravasation of monocytes rather than T cells across the blood-brain barrier.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Aug, 2017 | Pubmed ID: 28273717
A Novel Cervical Spinal Cord Window Preparation Allows for Two-Photon Imaging of T-Cell Interactions with the Cervical Spinal Cord Microvasculature during Experimental Autoimmune Encephalomyelitis.
Frontiers in immunology , 2017 | Pubmed ID: 28443093
The choroid plexus is a key cerebral invasion route for T cells after stroke.
Acta neuropathologica 12, 2017 | Pubmed ID: 28762187
ICAMs support B cell interactions with T follicular helper cells and promote clonal selection.
The Journal of experimental medicine Nov, 2017 | Pubmed ID: 28939548
Guidelines for the use of flow cytometry and cell sorting in immunological studies.
European journal of immunology Oct, 2017 | Pubmed ID: 29023707
Impaired T-cell migration to the CNS under fingolimod and dimethyl fumarate.
Neurology(R) neuroimmunology & neuroinflammation Nov, 2017 | Pubmed ID: 29075657
TNFα blockade mediates bone protection in antigen-induced arthritis by reducing osteoclast precursor supply.
Bone Feb, 2018 | Pubmed ID: 29081378
Immunosenescence in persons with spinal cord injury in relation to urinary tract infections -a cross-sectional study.
Immunity & ageing : I & A , 2017 | Pubmed ID: 29176992
Molecular anatomy and functions of the choroidal blood-cerebrospinal fluid barrier in health and disease.
Acta neuropathologica Mar, 2018 | Pubmed ID: 29368213
Cluster: barriers of the central nervous system.
Acta neuropathologica Mar, 2018 | Pubmed ID: 29397420
ICAM-1 C57BL/6 Mice Are Not Protected from Experimental Ischemic Stroke.
Translational stroke research Dec, 2018 | Pubmed ID: 29399739
Brain-released alarmins and stress response synergize in accelerating atherosclerosis progression after stroke.
Science translational medicine 03, 2018 | Pubmed ID: 29540615
Frequency and clinical characteristics of Multiple Sclerosis rebounds after withdrawal of Fingolimod.
CNS neuroscience & therapeutics Oct, 2018 | Pubmed ID: 29898493
Ischemia-reperfusion injury in stroke: impact of the brain barriers and brain immune privilege on neutrophil function.
Therapeutic advances in neurological disorders , 2018 | Pubmed ID: 30181779
A silicon nanomembrane platform for the visualization of immune cell trafficking across the human blood-brain barrier under flow.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Mar, 2019 | Pubmed ID: 30565961
PECAM-1 Stabilizes Blood-Brain Barrier Integrity and Favors Paracellular T-Cell Diapedesis Across the Blood-Brain Barrier During Neuroinflammation.
Frontiers in immunology , 2019 | Pubmed ID: 31024547
CD49d/CD29-integrin controls the accumulation of plasmacytoid dendritic cells into the CNS during neuroinflammation.
European journal of immunology Nov, 2019 | Pubmed ID: 31318439
Publisher Correction: Claudin-3-deficient C57BL/6J mice display intact brain barriers.
Scientific reports Jul, 2019 | Pubmed ID: 31320665
Claudin-12 is not required for blood-brain barrier tight junction function.
Fluids and barriers of the CNS Sep, 2019 | Pubmed ID: 31511021
Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition).
European journal of immunology Oct, 2019 | Pubmed ID: 31633216
Structure and Junctional Complexes of Endothelial, Epithelial and Glial Brain Barriers.
International journal of molecular sciences Oct, 2019 | Pubmed ID: 31671721
Distinct migratory pattern of naive and effector T cells through the blood-CSF barrier following Echovirus 30 infection.
Journal of neuroinflammation Nov, 2019 | Pubmed ID: 31752904
Sleep enhances numbers and function of monocytes and improves bacterial infection outcome in mice.
Brain, behavior, and immunity Jul, 2020 | Pubmed ID: 31904407
Functional relevance of the multi-drug transporter abcg2 on teriflunomide therapy in an animal model of multiple sclerosis.
Journal of neuroinflammation Jan, 2020 | Pubmed ID: 31915017
Intercellular Adhesion Molecule-1 (ICAM-1) and ICAM-2 Differentially Contribute to Peripheral Activation and CNS Entry of Autoaggressive Th1 and Th17 Cells in Experimental Autoimmune Encephalomyelitis.
Frontiers in immunology , 2019 | Pubmed ID: 31993059
Human CD4 T cell subsets differ in their abilities to cross endothelial and epithelial brain barriers in vitro.
Fluids and barriers of the CNS Feb, 2020 | Pubmed ID: 32008573
Angiopoietin-2 blockade ameliorates autoimmune neuroinflammation by inhibiting leukocyte recruitment into the CNS.
The Journal of clinical investigation Apr, 2020 | Pubmed ID: 32149735
CD31 (PECAM-1) Serves as the Endothelial Cell-Specific Receptor of Clostridium perfringens β-Toxin.
Cell host & microbe Jul, 2020 | Pubmed ID: 32497498
Oligomeric Forms of Human Amyloid-Beta(1-42) Inhibit Antigen Presentation.
Frontiers in immunology , 2020 | Pubmed ID: 32582162
Contribution of brain pericytes in blood-brain barrier formation and maintenance: a transcriptomic study of cocultured human endothelial cells derived from hematopoietic stem cells.
Fluids and barriers of the CNS Jul, 2020 | Pubmed ID: 32723387
Advancing brain barriers RNA sequencing: guidelines from experimental design to publication.
Fluids and barriers of the CNS Aug, 2020 | Pubmed ID: 32811511
Morpholino Analogues of Fingolimod as Novel and Selective S1P Ligands with In Vivo Efficacy in a Mouse Model of Experimental Antigen-Induced Encephalomyelitis.
International journal of molecular sciences Sep, 2020 | Pubmed ID: 32899717
Immune cell trafficking across the blood-brain barrier in the absence and presence of neuroinflammation.
Vascular biology (Bristol, England) , 2020 | Pubmed ID: 32923970
Microglia Get a Little Help from "Th"-eir Friends.
Immunity Sep, 2020 | Pubmed ID: 32937150
Advancing human induced pluripotent stem cell-derived blood-brain barrier models for studying immune cell interactions.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Dec, 2020 | Pubmed ID: 33124083
Innovative high-resolution microCT imaging of animal brain vasculature.
Brain structure & function Dec, 2020 | Pubmed ID: 33128675
Brain Barriers and Multiple Sclerosis: Novel Treatment Approaches from a Brain Barriers Perspective.
Handbook of experimental pharmacology , 2022 | Pubmed ID: 33237504
T Cell-Mediated Transport of Polymer Nanoparticles across the Blood-Brain Barrier.
Advanced healthcare materials Jan, 2021 | Pubmed ID: 33241667
Maternal Infection Impairs Fetal Brain Development via Choroid Plexus Inflammation.
Developmental cell Dec, 2020 | Pubmed ID: 33290691
Novel compounds with dual S1P receptor agonist and histamine H receptor antagonist activities act protective in a mouse model of multiple sclerosis.
Neuropharmacology Mar, 2021 | Pubmed ID: 33460688
Biotin-NeutrAvidin Mediated Immobilization of Polymer Micro- and Nanoparticles on T Lymphocytes.
Bioconjugate chemistry Mar, 2021 | Pubmed ID: 33621057
Histone deacetylase 1 controls CD4 T cell trafficking in autoinflammatory diseases.
Journal of autoimmunity 05, 2021 | Pubmed ID: 33621930
Selective Endocannabinoid Reuptake Inhibitor WOBE437 Reduces Disease Progression in a Mouse Model of Multiple Sclerosis.
ACS pharmacology & translational science Apr, 2021 | Pubmed ID: 33860200
Loss of Claudin-3 Impairs Hepatic Metabolism, Biliary Barrier Function, and Cell Proliferation in the Murine Liver.
Cellular and molecular gastroenterology and hepatology , 2021 | Pubmed ID: 33866021
Brain endothelial tricellular junctions as novel sites for T cell diapedesis across the blood-brain barrier.
Journal of cell science Apr, 2021 | Pubmed ID: 33912914
Pro-resolving lipid mediator lipoxin A attenuates neuro-inflammation by modulating T cell responses and modifies the spinal cord lipidome.
Cell reports Jun, 2021 | Pubmed ID: 34077725
Differentiation of human pluripotent stem cells to brain microvascular endothelial cell-like cells suitable to study immune cell interactions.
STAR protocols Jun, 2021 | Pubmed ID: 34151293
Covalent and Noncovalent Conjugation of Degradable Polymer Nanoparticles to T Lymphocytes.
Biomacromolecules Aug, 2021 | Pubmed ID: 34170107
ACKR1 favors transcellular over paracellular T-cell diapedesis across the blood-brain barrier in neuroinflammation in vitro.
European journal of immunology Jan, 2022 | Pubmed ID: 34524684
Wnt signaling mediates acquisition of blood-brain barrier properties in naïve endothelium derived from human pluripotent stem cells.
eLife Nov, 2021 | Pubmed ID: 34755601
The blood-CSF-brain route of neurological disease: The indirect pathway into the brain.
Neuropathology and applied neurobiology , | Pubmed ID: 34935179
Nano-scale architecture of blood-brain barrier tight-junctions.
eLife Dec, 2021 | Pubmed ID: 34951586
Intrinsic blood-brain barrier dysfunction contributes to multiple sclerosis pathogenesis.
Brain : a journal of neurology Dec, 2022 | Pubmed ID: 35085379
Central nervous system zoning: How brain barriers establish subdivisions for CNS immune privilege and immune surveillance.
Journal of internal medicine Jul, 2022 | Pubmed ID: 35184353
Brain barriers virtual: an interim solution or future opportunity?
Fluids and barriers of the CNS Mar, 2022 | Pubmed ID: 35232464
COVID-19 and the Vasculature: Current Aspects and Long-Term Consequences.
Frontiers in cell and developmental biology , 2022 | Pubmed ID: 35242762
Multiple sclerosis: Immunopathological heterogeneity and its implications.
European journal of immunology Jun, 2022 | Pubmed ID: 35476319
Autoimmune neuroinflammation triggers mitochondrial oxidation in oligodendrocytes.
Glia Nov, 2022 | Pubmed ID: 35762739
Full spectrum of vitamin D immunomodulation in multiple sclerosis: mechanisms and therapeutic implications.
Brain communications , 2022 | Pubmed ID: 35813882
The Modular µSiM: A Mass Produced, Rapidly Assembled, and Reconfigurable Platform for the Study of Barrier Tissue Models In Vitro.
Advanced healthcare materials Jul, 2022 | Pubmed ID: 35899801
Connexins orchestrate progression of breast cancer metastasis to the brain by promoting FAK activation.
Science translational medicine Sep, 2022 | Pubmed ID: 36070364
A potent and selective inhibitor for the modulation of MAGL activity in the neurovasculature.
PloS one , 2022 | Pubmed ID: 36084029
Perivascular spaces and their role in neuroinflammation.
Neuron Nov, 2022 | Pubmed ID: 36327898
Bovine neutrophil chemotaxis to Listeria monocytogenes in neurolisteriosis depends on microglia-released rather than bacterial factors.
Journal of neuroinflammation Dec, 2022 | Pubmed ID: 36527076
Modeling Brain Vasculature Immune Interactions In Vitro.
Cold Spring Harbor perspectives in medicine Dec, 2022 | Pubmed ID: 36617644
Macrophages clear the way for CNS fluid flow.
The Lancet. Neurology Mar, 2023 | Pubmed ID: 36804079
Insulin-like growth factor-1 receptor controls the function of CNS-resident macrophages and their contribution to neuroinflammation.
Acta neuropathologica communications Mar, 2023 | Pubmed ID: 36890580
Open pathways for cerebrospinal fluid outflow at the cribriform plate along the olfactory nerves.
EBioMedicine May, 2023 | Pubmed ID: 37043871
Blockade of VEGFR3 signaling leads to functional impairment of dural lymphatic vessels without affecting autoimmune neuroinflammation.
Science immunology Apr, 2023 | Pubmed ID: 37058549
Effects of a Small-Molecule Perforin Inhibitor in a Mouse Model of CD8 T Cell-Mediated Neuroinflammation.
Neurology(R) neuroimmunology & neuroinflammation Jul, 2023 | Pubmed ID: 37080596
High levels of endothelial ICAM-1 prohibit natalizumab mediated abrogation of CD4 T cell arrest on the inflamed BBB under flow in vitro.
Journal of neuroinflammation May, 2023 | Pubmed ID: 37221552
Antigen recognition detains CD8 T cells at the blood-brain barrier and contributes to its breakdown.
Nature communications May, 2023 | Pubmed ID: 37253744
The choroid plexus acts as an immune cell reservoir and brain entry site in experimental autoimmune encephalomyelitis.
Fluids and barriers of the CNS Jun, 2023 | Pubmed ID: 37264368
Integration of immune cells in organs-on-chips: a tutorial.
Frontiers in bioengineering and biotechnology , 2023 | Pubmed ID: 37324438
Correction to: The choroid plexus acts as an immune cell reservoir and brain entry site in experimental autoimmune encephalomyelitis.
Fluids and barriers of the CNS Jul, 2023 | Pubmed ID: 37452369
VE-cadherin in arachnoid and pia mater cells serves as a suitable landmark for in vivo imaging of CNS immune surveillance and inflammation.
Nature communications Sep, 2023 | Pubmed ID: 37730744
Molecular anatomy of adult mouse leptomeninges.
Neuron Dec, 2023 | Pubmed ID: 37776854
A20 regulates lymphocyte adhesion in murine neuroinflammation by restricting endothelial ICOSL expression in the CNS.
The Journal of clinical investigation Dec, 2023 | Pubmed ID: 37856217
SARS-CoV-2 infects epithelial cells of the blood-cerebrospinal fluid barrier rather than endothelial cells or pericytes of the blood-brain barrier.
Fluids and barriers of the CNS Oct, 2023 | Pubmed ID: 37875964
Compromised Blood-Brain Barrier Junctions Enhance Melanoma Cell Intercalation and Extravasation.
Cancers Oct, 2023 | Pubmed ID: 37894438
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