Department of Applied Biology and Chemistry Technology,
Institute of Modern Chinese Medicine,
Department of Applied Biology and Chemistry Technology, Institute of Modern Chinese Medicine
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Protection against 1-methyl-4-phenylpyridinium ion (MPP+)-induced apoptosis by water extract of ginseng (Panax ginseng C.A. Meyer) in SH-SY5Y cells.
Journal of ethnopharmacology Apr, 2011 | Pubmed ID: 21349320
Bis(12)-hupyridone, a novel multifunctional dimer, promotes neuronal differentiation more potently than its monomeric natural analog huperzine A possibly through α7 nAChR.
Brain research Jul, 2011 | Pubmed ID: 21665194
PI3-K/Akt and ERK pathways activated by VEGF play opposite roles in MPP+-induced neuronal apoptosis.
Neurochemistry international Nov, 2011 | Pubmed ID: 21781996
Tacrine(2)-ferulic acid, a novel multifunctional dimer, attenuates 6-hydroxydopamine-induced apoptosis in PC12 cells by activating Akt pathway.
Neurochemistry international Dec, 2011 | Pubmed ID: 21939707
Unexpected neuronal protection of SU5416 against 1-Methyl-4-phenylpyridinium ion-induced toxicity via inhibiting neuronal nitric oxide synthase.
PloS one , 2012 | Pubmed ID: 23049997
The anti-cancer agent SU4312 unexpectedly protects against MPP(+) -induced neurotoxicity via selective and direct inhibition of neuronal NOS.
British journal of pharmacology Mar, 2013 | Pubmed ID: 23062100
Bis(12)-hupyridone, a novel acetylcholinesterase inhibitor, protects against glutamate-induced neuronal excitotoxicity via activating α7 nicotinic acetylcholine receptor/phosphoinositide 3-kinase/Akt cascade.
Chemico-biological interactions Mar, 2013 | Pubmed ID: 23085120
Bis(propyl)-cognitin protects against glutamate-induced neuro-excitotoxicity via concurrent regulation of NO, MAPK/ERK and PI3-K/Akt/GSK3β pathways.
Neurochemistry international Mar, 2013 | Pubmed ID: 23357479
Synergistic inhibition on acetylcholinesterase by the combination of berberine and palmatine originally isolated from Chinese medicinal herbs.
Journal of molecular neuroscience : MN Jul, 2014 | Pubmed ID: 24793543
Inhibiting β-amyloid-associated Alzheimer's pathogenesis in vitro and in vivo by a multifunctional dimeric bis(12)-hupyridone derived from its natural analogue.
Journal of molecular neuroscience : MN Apr, 2015 | Pubmed ID: 25407821
Substantial Neuroprotective and Neurite Outgrowth-Promoting Activities by Bis(propyl)-cognitin via the Activation of Alpha7-nAChR, a Promising Anti-Alzheimer's Dimer.
ACS chemical neuroscience Sep, 2015 | Pubmed ID: 26147504
Protection against β-amyloid-induced synaptic and memory impairments via altering β-amyloid assembly by bis(heptyl)-cognitin.
Scientific reports Jul, 2015 | Pubmed ID: 26194093
Indirubin-3-Oxime Effectively Prevents 6OHDA-Induced Neurotoxicity in PC12 Cells via Activating MEF2D Through the Inhibition of GSK3β.
Journal of molecular neuroscience : MN Dec, 2015 | Pubmed ID: 26346600
Tanshinone II A, a multiple target neuroprotectant, promotes caveolae-dependent neuronal differentiation.
European journal of pharmacology Oct, 2015 | Pubmed ID: 26363255
Sunitinib, a Clinically Used Anticancer Drug, Is a Potent AChE Inhibitor and Attenuates Cognitive Impairments in Mice.
ACS chemical neuroscience Aug, 2016 | Pubmed ID: 27046396
Potent Protection Against MPP(+)-Induced Neurotoxicity via Activating Transcription Factor MEF2D by a Novel Derivative of Naturally Occurring Danshensu/Tetramethylpyrazine.
Neuromolecular medicine Dec, 2016 | Pubmed ID: 27277280
Indirubin-3-Oxime Prevents H2O2-Induced Neuronal Apoptosis via Concurrently Inhibiting GSK3β and the ERK Pathway.
Cellular and molecular neurobiology May, 2017 | Pubmed ID: 27412761
Neuroprotection against glutamate-induced excitotoxicity and induction of neurite outgrowth by T-006, a novel multifunctional derivative of tetramethylpyrazine in neuronal cell models.
Neurochemistry international Oct, 2016 | Pubmed ID: 27445088
Lin Jiajia*,1,
Mak Shinghung*,2,
Zheng Jiacheng1,
Wang Jialing1,
Xu Dilin1,
Hu Shengquan2,
Zhang Zaijun3,
Wang Qinwen1,
Han Yifan2,4,
Cui Wei1,2
1Ningbo Key Laboratory of Behavioral Neuroscience, Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University,
2Department of Applied Biology and Chemistry Technology, Institute of Modern Chinese Medicine, The Hong Kong Polytechnic University,
3Institute of New Drug Research, Guangdong Provincial Key Laboratory of Pharmacodynamic, Constituents of Traditional Chinese Medicine & New Drug Research, College of Pharmacy, Jinan University,
4, International Joint Laboratory (SYSU-PolyU HK) of Novel Anti-Dementia Drugs of Guangdong
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