Departments of Pharmacology and Medicine,
Section of Hematology and Medical Oncology,
The Cancer Research Center,
Departments of Pharmacology and Medicine, Section of Hematology and Medical Oncology, The Cancer Research Center
Trained as a physician and cancer biologist, Dr. Feng has applied the zebrafish as a model to study MYC-driven cancers over seventeen years. Her laboratory at Boston University (www.bu.edu/zgct) utilizes multiple zebrafish models of cancer to gain mechanistic insights into MYC-mediated oncogenic pathways and identify novel therapeutic targets for MYC-driven cancers.
BCL2-specific inhibitor ABT-199 synergizes strongly with cytarabine against the early immature LOUCY cell line but not more-differentiated T-ALL cell lines.
Leukemia May, 2014 | Pubmed ID: 24342948
Loss of function tp53 mutations do not accelerate the onset of myc-induced T-cell acute lymphoblastic leukaemia in the zebrafish.
British journal of haematology Jul, 2014 | Pubmed ID: 24690081
The c-Cbl ubiquitin ligase regulates nuclear β-catenin and angiogenesis by its tyrosine phosphorylation mediated through the Wnt signaling pathway.
The Journal of biological chemistry May, 2015 | Pubmed ID: 25784557
Hypoxia-induced expression of phosducin-like 3 regulates expression of VEGFR-2 and promotes angiogenesis.
Angiogenesis Oct, 2015 | Pubmed ID: 26059764
Efficient transgenesis mediated by pigmentation rescue in zebrafish.
BioTechniques Jan, 2016 | Pubmed ID: 26757807
Zebrafish Models of Human Leukemia: Technological Advances and Mechanistic Insights.
Advances in experimental medicine and biology , 2016 | Pubmed ID: 27165361
CK2 inhibitor CX-4945 destabilizes NOTCH1 and synergizes with JQ1 against human T-acute lymphoblastic leukemic cells.
Haematologica 01, 2017 | Pubmed ID: 27758824
Aberrant activation of the GIMAP enhancer by oncogenic transcription factors in T-cell acute lymphoblastic leukemia.
Leukemia 08, 2017 | Pubmed ID: 28028313
Zebrafish B Cell Development without a Pre-B Cell Stage, Revealed by CD79 Fluorescence Reporter Transgenes.
Journal of immunology (Baltimore, Md. : 1950) 09, 2017 | Pubmed ID: 28739882
The emerging role and targetability of the TCA cycle in cancer metabolism.
Protein & cell 02, 2018 | Pubmed ID: 28748451
Towards Resolving the Pro- and Anti-Tumor Effects of the Aryl Hydrocarbon Receptor.
International journal of molecular sciences May, 2018 | Pubmed ID: 29735912
UFD1 contributes to MYC-mediated leukemia aggressiveness through suppression of the proapoptotic unfolded protein response.
Leukemia 11, 2018 | Pubmed ID: 29743725
Functional and genomic analyses reveal therapeutic potential of targeting β-catenin/CBP activity in head and neck cancer.
Genome medicine 07, 2018 | Pubmed ID: 30029671
SHQ1 regulation of RNA splicing is required for T-lymphoblastic leukemia cell survival.
Nature communications 10, 2018 | Pubmed ID: 30323192
Data on ultrabright fluorescent cellulose acetate nanoparticles for imaging tumors through systemic and topical applications.
Data in brief Feb, 2019 | Pubmed ID: 30596135
Ultrabright fluorescent cellulose acetate nanoparticles for imaging tumors through systemic and topical applications.
Materials today (Kidlington, England) Mar, 2019 | Pubmed ID: 31057328
Promoter demethylation of the asparagine synthetase gene is required for ATF4-dependent adaptation to asparagine depletion.
The Journal of biological chemistry Dec, 2019 | Pubmed ID: 31659118
Glutamine Anabolism Plays a Critical Role in Pancreatic Cancer by Coupling Carbon and Nitrogen Metabolism.
Cell reports Oct, 2019 | Pubmed ID: 31665640
Targeting RICTOR Sensitizes SMAD4-Negative Colon Cancer to Irinotecan.
Molecular cancer research : MCR 03, 2020 | Pubmed ID: 31932471
Direct Phosphorylation and Stabilization of MYC by Aurora B Kinase Promote T-cell Leukemogenesis.
Cancer cell Feb, 2020 | Pubmed ID: 32049046
Cross organelle stress response disruption promotes gentamicin-induced proteotoxicity.
Cell death & disease Apr, 2020 | Pubmed ID: 32245975
Xiaodan Qin*,1,
Fabrice F. J. Laroche*,1,
Saquib Ahmed M. A. Peerzade2,
Andrew Lam1,
Igor Sokolov2,3,4,
Hui Feng1
1Departments of Pharmacology and Medicine, Section of Hematology and Medical Oncology, The Cancer Research Center, Boston University School of Medicine,
2Department of Biomedical Engineering, Tufts University,
3Department of Mechanical Engineering, Tufts University,
4Department of Physics, Tufts University
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