John C. Schimenti

The mouse genomic instability mutation chaos1 is an allele of Polq that exhibits genetic interaction with Atm.

Random mutagenesis of proximal mouse chromosome 5 uncovers predominantly embryonic lethal mutations.

The translesion DNA polymerase theta plays a dominant role in immunoglobulin gene somatic hypermutation.

Mutation of a ubiquitously expressed mouse transmembrane protein (Tapt1) causes specific skeletal homeotic transformations.

A dominant, recombination-defective allele of Dmc1 causing male-specific sterility.

Different regulatory systems operate in the midpiece and principal piece of the mammalian sperm flagellum.

Mouse pachytene checkpoint 2 (trip13) is required for completing meiotic recombination but not synapsis.

Mutation in mouse hei10, an e3 ubiquitin ligase, disrupts meiotic crossing over.

The dual bromodomain and WD repeat-containing mouse protein BRWD1 is required for normal spermiogenesis and the oocyte-embryo transition.

Development and use of DNA archives at veterinary teaching hospitals to investigate the genetic basis of disease in dogs.

Mouse H6 Homeobox 1 (Hmx1) mutations cause cranial abnormalities and reduced body mass.

Aneuploidy and improved growth are coincident but not causal in a yeast cancer model.

SEL1L deficiency impairs growth and differentiation of pancreatic epithelial cells.

Deficiency of suppressor enhancer Lin12 1 like (SEL1L) in mice leads to systemic endoplasmic reticulum stress and embryonic lethality.

An allele separating skeletal patterning and spermatogonial renewal functions of PLZF.

PDCD2 is essential for inner cell mass development and embryonic stem cell maintenance.

The full-length isoform of the mouse pleckstrin homology domain-interacting protein (PHIP) is required for postnatal growth.

Incremental genetic perturbations to MCM2-7 expression and subcellular distribution reveal exquisite sensitivity of mice to DNA replication stress.

High resolution mapping and positional cloning of ENU-induced mutations in the Rw region of mouse chromosome 5.

A reduction of licensed origins reveals strain-specific replication dynamics in mice.

A-MYB (MYBL1) transcription factor is a master regulator of male meiosis.

Genetic evidence that synaptonemal complex axial elements govern recombination pathway choice in mice.

Evidence Implicating CCNB1IP1, a RING Domain-Containing Protein Required for Meiotic Crossing Over in Mice, as an E3 SUMO Ligase.

Minichromosome maintenance helicase paralog MCM9 is dispensible for DNA replication but functions in germ-line stem cells and tumor suppression.

Spata22, a novel vertebrate-specific gene, is required for meiotic progress in mouse germ cells.

Haploid embryonic stem cells and the dominance of recessive traits.

Phosphorylation of chromosome core components may serve as axis marks for the status of chromosomal events during mammalian meiosis.

MCM4 mutation causes adrenal failure, short stature, and natural killer cell deficiency in humans.

Post-transcriptional homeostasis and regulation of MCM2-7 in mammalian cells.

MARF1 regulates essential oogenic processes in mice.

Comparative oncogenomics implicates the neurofibromin 1 gene (NF1) as a breast cancer driver.

Genetic background affects induced pluripotent stem cell generation.

Genetics of meiosis and recombination in mice.

Using genetic networks and homology to understand the evolution of phenotypic traits.

Tissue-specific functional networks for prioritizing phenotype and disease genes.

Meiosis arrest female 1 (MARF1) has nuage-like function in mammalian oocytes.

Interallelic and intergenic incompatibilities of the Prdm9 (Hst1) gene in mouse hybrid sterility.

The MCM8-MCM9 complex promotes RAD51 recruitment at DNA damage sites to facilitate homologous recombination.

An ancient transcription factor initiates the burst of piRNA production during early meiosis in mouse testes.

AKAP9 is essential for spermatogenesis and sertoli cell maturation in mice.

Role of DNA damage response pathways in preventing carcinogenesis caused by intrinsic replication stress.

Female mice lacking estrogen receptor-alpha in osteoblasts have compromised bone mass and strength.

IQ motif-containing G (Iqcg) is required for mouse spermiogenesis.

Reversal of female infertility by Chk2 ablation reveals the oocyte DNA damage checkpoint pathway.

STAG3 is a strong candidate gene for male infertility.

miR-34 cooperates with p53 in suppression of prostate cancer by joint regulation of stem cell compartment.

Induced pluripotent stem cells have similar immunogenic and more potent immunomodulatory properties compared with bone marrow-derived stromal cells in vitro.

Applying "gold standards" to in-vitro-derived germ cells.

Hypersensitivity of primordial germ cells to compromised replication-associated DNA repair involves ATM-p53-p21 signaling.

A method for isolating high quality RNA from mouse cortical and cancellous bone.

A mouse geneticist's practical guide to CRISPR applications.

Mouse BRWD1 is critical for spermatid postmeiotic transcription and female meiotic chromosome stability.

Effects of Deletion of ERα in Osteoblast-Lineage Cells on Bone Mass and Adaptation to Mechanical Loading Differ in Female and Male Mice.

Mechanism and regulation of rapid telomere prophase movements in mouse meiotic chromosomes.

The genetics of human infertility by functional interrogation of SNPs in mice.

MCM9 deficiency delays primordial germ cell proliferation independent of the ATM pathway.

Chronic DNA Replication Stress Reduces Replicative Lifespan of Cells by TRP53-Dependent, microRNA-Assisted MCM2-7 Downregulation.

Transcriptional profiling of cortical versus cancellous bone from mechanically-loaded murine tibiae reveals differential gene expression.

L. C. Dunn and Donald Charles on Quantitative Traits in the Mouse.

The Chromatin Remodeling Component Arid1a Is a Suppressor of Spontaneous Mammary Tumors in Mice.

Repair of Meiotic DNA Breaks and Homolog Pairing in Mouse Meiosis Requires a Minichromosome Maintenance (MCM) Paralog.

Pharmacological Inhibition of the DNA Damage Checkpoint Prevents Radiation-Induced Oocyte Death.

The DNA Damage Checkpoint Eliminates Mouse Oocytes with Chromosome Synapsis Failure.