Jonathan W. Astin
Department of Molecular Medicine and Pathology,
School of Medical Sciences,
Faculty of Medical and Health Sciences,
Department of Molecular Medicine and Pathology, School of Medical Sciences
University of Auckland
My research focuses on understanding how vascular development is regulated. My research utilises the zebrafish model of vertebrate development which has transgenic tools that allow us to visualise the developing lymphatic and blood vessels. We couple high-resolution in vivo imaging with both forward and reverse genetics, to uncover how blood and lymphatic vessels form in the developing embryo.
DMXAA (Vadimezan, ASA404) is a multi-kinase inhibitor targeting VEGFR2 in particular.
Clinical science (London, England : 1979) May, 2012 | Pubmed ID: 22142330
lyve1 expression reveals novel lymphatic vessels and new mechanisms for lymphatic vessel development in zebrafish.
Development (Cambridge, England) Jul, 2012 | Pubmed ID: 22627281
Immunoresponsive gene 1 augments bactericidal activity of macrophage-lineage cells by regulating β-oxidation-dependent mitochondrial ROS production.
Cell metabolism Aug, 2013 | Pubmed ID: 23931757
Pkd1 regulates lymphatic vascular morphogenesis during development.
Cell reports May, 2014 | Pubmed ID: 24767999
Vegfd can compensate for loss of Vegfc in zebrafish facial lymphatic sprouting.
Development (Cambridge, England) Jul, 2014 | Pubmed ID: 24903752
An in vivo antilymphatic screen in zebrafish identifies novel inhibitors of mammalian lymphangiogenesis and lymphatic-mediated metastasis.
Molecular cancer therapeutics Oct, 2014 | Pubmed ID: 25053822
An inducible transgene reports activation of macrophages in live zebrafish larvae.
Developmental and comparative immunology Nov, 2015 | Pubmed ID: 26123890
mafba is a downstream transcriptional effector of Vegfc signaling essential for embryonic lymphangiogenesis in zebrafish.
Genes & development Aug, 2015 | Pubmed ID: 26253536
A zebrafish model of inflammatory lymphangiogenesis.
Biology open Sep, 2015 | Pubmed ID: 26369931
Lymphatics, Cancer and Zebrafish.
Advances in experimental medicine and biology , 2016 | Pubmed ID: 27165355
The innate immune cell response to bacterial infection in larval zebrafish is light-regulated.
Scientific reports 10, 2017 | Pubmed ID: 28978916
Blocking fatty acid-fueled mROS production within macrophages alleviates acute gouty inflammation.
The Journal of clinical investigation May, 2018 | Pubmed ID: 29584621
Characterization of Zebrafish Facial Lymphatics.
Methods in molecular biology (Clifton, N.J.) , 2018 | Pubmed ID: 30242753
Macrophages enhance Vegfa-driven angiogenesis in an embryonic zebrafish tumour xenograft model.
Disease models & mechanisms 11, 2018 | Pubmed ID: 30396905
Liposome-Mediated Drug Delivery in Larval Zebrafish to Manipulate Macrophage Function.
Zebrafish Apr, 2019 | Pubmed ID: 30724716
Zebrafish facial lymphatics develop through sequential addition of venous and non-venous progenitors.
EMBO reports May, 2019 | Pubmed ID: 30877134
In Vivo Imaging and Quantitation of the Host Angiogenic Response in Zebrafish Tumor Xenografts
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