Molecular and Clinical Nutrition Section,
Digestive Diseases Branch,
Molecular and Clinical Nutrition Section, Digestive Diseases Branch
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Ascorbate recycling in human neutrophils: induction by bacteria.
Proceedings of the National Academy of Sciences of the United States of America Dec, 1997 | Pubmed ID: 9391110
New insights into the physiology and pharmacology of vitamin C.
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne Feb, 2001 | Pubmed ID: 11232136
A new recommended dietary allowance of vitamin C for healthy young women.
Proceedings of the National Academy of Sciences of the United States of America Aug, 2001 | Pubmed ID: 11504949
Cloning and functional characterization of the mouse fructose transporter, GLUT5.
Biochimica et biophysica acta Jun, 2002 | Pubmed ID: 12031501
Vitamin C as an antioxidant: evaluation of its role in disease prevention.
Journal of the American College of Nutrition Feb, 2003 | Pubmed ID: 12569111
Vitamin C pharmacokinetics: implications for oral and intravenous use.
Annals of internal medicine Apr, 2004 | Pubmed ID: 15068981
Comparison of the genomic structure and variation in the two human sodium-dependent vitamin C transporters, SLC23A1 and SLC23A2.
Human genetics Sep, 2004 | Pubmed ID: 15316768
Pharmacologic ascorbic acid concentrations selectively kill cancer cells: action as a pro-drug to deliver hydrogen peroxide to tissues.
Proceedings of the National Academy of Sciences of the United States of America Sep, 2005 | Pubmed ID: 16157892
Intravenously administered vitamin C as cancer therapy: three cases.
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne Mar, 2006 | Pubmed ID: 16567755
Inhibition of the intestinal glucose transporter GLUT2 by flavonoids.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Feb, 2007 | Pubmed ID: 17172639
Ascorbate in pharmacologic concentrations selectively generates ascorbate radical and hydrogen peroxide in extracellular fluid in vivo.
Proceedings of the National Academy of Sciences of the United States of America May, 2007 | Pubmed ID: 17502596
Human adrenal glands secrete vitamin C in response to adrenocorticotrophic hormone.
The American journal of clinical nutrition Jul, 2007 | Pubmed ID: 17616774
Hypoxia-inducible factor-1alpha stabilization in nonhypoxic conditions: role of oxidation and intracellular ascorbate depletion.
Molecular biology of the cell Jan, 2008 | Pubmed ID: 17942596
Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice.
Proceedings of the National Academy of Sciences of the United States of America Aug, 2008 | Pubmed ID: 18678913
Genetic variation in sodium-dependent vitamin C transporters SLC23A1 and SLC23A2 and risk of advanced colorectal adenoma.
Nutrition and cancer , 2008 | Pubmed ID: 18791929
Genomic and functional analysis of the sodium-dependent vitamin C transporter SLC23A1-SVCT1.
Genes & nutrition Oct, 2007 | Pubmed ID: 18850166
Oxalic acid excretion after intravenous ascorbic acid administration.
Metabolism: clinical and experimental Feb, 2009 | Pubmed ID: 19154961
Losing and finding a way at C: new promise for pharmacologic ascorbate in cancer treatment.
Free radical biology & medicine Jul, 2009 | Pubmed ID: 19361554
Major contribution of tubular secretion to creatinine clearance in mice.
Kidney international Mar, 2010 | Pubmed ID: 20032962
Vitamin C transporter Slc23a1 links renal reabsorption, vitamin C tissue accumulation, and perinatal survival in mice.
The Journal of clinical investigation Apr, 2010 | Pubmed ID: 20200446
Vitamin C: intravenous use by complementary and alternative medicine practitioners and adverse effects.
PloS one Jul, 2010 | Pubmed ID: 20628650
Pharmacologic ascorbate synergizes with gemcitabine in preclinical models of pancreatic cancer.
Free radical biology & medicine Jun, 2011 | Pubmed ID: 21402145
Measurement of plasma volume using fluorescent silica-based nanoparticles.
Journal of applied physiology (Bethesda, Md. : 1985) Feb, 2012 | Pubmed ID: 22174395
Phase I evaluation of intravenous ascorbic acid in combination with gemcitabine and erlotinib in patients with metastatic pancreatic cancer.
PloS one , 2012 | Pubmed ID: 22272248
Vitamin C: a concentration-function approach yields pharmacology and therapeutic discoveries.
Advances in nutrition (Bethesda, Md.) Mar, 2011 | Pubmed ID: 22332036
Vitamin C in mouse and human red blood cells: an HPLC assay.
Analytical biochemistry Jul, 2012 | Pubmed ID: 22522059
Ascorbic acid kills Epstein-Barr virus positive Burkitt lymphoma cells and Epstein-Barr virus transformed B-cells in vitro, but not in vivo.
Leukemia & lymphoma May, 2013 | Pubmed ID: 23067008
Parenteral ascorbate as a cancer therapeutic: a reassessment based on pharmacokinetics.
Antioxidants & redox signaling Dec, 2013 | Pubmed ID: 23621620
The human sodium-dependent ascorbic acid transporters SLC23A1 and SLC23A2 do not mediate ascorbic acid release in the proximal renal epithelial cell.
Physiological reports Nov, 2013 | Pubmed ID: 24400138
Antitumor effect of pharmacologic ascorbate in the B16 murine melanoma model.
Free radical biology & medicine Oct, 2015 | Pubmed ID: 26119785
Vitamin C: the known and the unknown and Goldilocks.
Oral diseases Sep, 2016 | Pubmed ID: 26808119
Low Red Blood Cell Vitamin C Concentrations Induce Red Blood Cell Fragility: A Link to Diabetes Via Glucose, Glucose Transporters, and Dehydroascorbic Acid.
EBioMedicine Nov, 2015 | Pubmed ID: 26870799
Synergistic effects of ascorbate and sorafenib in hepatocellular carcinoma: New insights into ascorbate cytotoxicity.
Free radical biology & medicine 06, 2016 | Pubmed ID: 27036367
Breaking down, starting up: can a vitamin C-enriched gelatin supplement before exercise increase collagen synthesis?
The American journal of clinical nutrition Jan, 2017 | Pubmed ID: 28003207
Data Triumph at C.
Cancer cell 04, 2017 | Pubmed ID: 28399404
Measurements of red cell deformability and hydration reflect HbF and HbA2 in blood from patients with sickle cell anemia.
Blood cells, molecules & diseases Jun, 2017 | Pubmed ID: 28472705
Chemical Transport Knockout for Oxidized Vitamin C, Dehydroascorbic Acid, Reveals Its Functions in vivo.
EBioMedicine Sep, 2017 | Pubmed ID: 28851583
The SLC2A14 gene, encoding the novel glucose/dehydroascorbate transporter GLUT14, is associated with inflammatory bowel disease.
The American journal of clinical nutrition Dec, 2017 | Pubmed ID: 28971850
State of the Science: Cancer Complementary and Alternative Medicine Therapeutics Research-NCI Strategic Workshop Highlights of Discussion Report.
Journal of the National Cancer Institute. Monographs Nov, 2017 | Pubmed ID: 29140484
Nermi L. Parrow*,1,
Pierre-Christian Violet*,2,
Hongbin Tu2,
James Nichols3,
Corinne A. Pittman4,
Courtney Fitzhugh4,
Robert E. Fleming1,5,
Narla Mohandas6,
John F. Tisdale3,
Mark Levine2
1Department of Pediatrics, Saint Louis University School of Medicine,
2Molecular and Clinical Nutrition Section, Digestive Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases,
3Molecular and Clinical Hematology Branch, National Institute of Diabetes and Digestive and Kidney Diseases,
4Sickle Cell Branch, National Heart, Lung and Blood Institute, National Institutes of Health,
5Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine,
6Red Cell Physiology Laboratory, New York Blood Center
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