Department of Pathology,
Immunology and Experimental Medicine,
Department of Pathology, Immunology and Experimental Medicine
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Pancreatic adenocarcinoma patients with localised chronic severe pancreatitis show an increased number of single beta cells, without alterations in fractional insulin area.
Diabetologia Feb, 2009 | Pubmed ID: 19002428
Adeno-associated virus vector-mediated IL-10 gene delivery prevents type 1 diabetes in NOD mice.
Proceedings of the National Academy of Sciences of the United States of America Nov, 2001 | Pubmed ID: 11717448
Benzo(a)pyrene, but not 2,3,7,8-tetrachlorodibenzo-p-dioxin, alters cell adhesion proteins in human uterine RL95-2 cells.
Biochemical and biophysical research communications May, 2002 | Pubmed ID: 12054747
Intramuscular administration of recombinant adeno-associated virus 2 alpha-1 antitrypsin (rAAV-SERPINA1) vectors in a nonhuman primate model: safety and immunologic aspects.
Molecular therapy : the journal of the American Society of Gene Therapy Sep, 2002 | Pubmed ID: 12231168
Adeno-associated virus transduction of islets with interleukin-4 results in impaired metabolic function in syngeneic marginal islet mass transplantation.
Transplantation Oct, 2002 | Pubmed ID: 12438968
Adeno-associated virus-mediated IL-10 gene therapy inhibits diabetes recurrence in syngeneic islet cell transplantation of NOD mice.
Diabetes Mar, 2003 | Pubmed ID: 12606512
Systemic overexpression of IL-10 induces CD4+CD25+ cell populations in vivo and ameliorates type 1 diabetes in nonobese diabetic mice in a dose-dependent fashion.
Journal of immunology (Baltimore, Md. : 1950) Sep, 2003 | Pubmed ID: 12928371
Sustained peripheral expression of transgene adiponectin offsets the development of diet-induced obesity in rats.
Proceedings of the National Academy of Sciences of the United States of America Nov, 2003 | Pubmed ID: 14617771
Heme oxygenase-1 modulates early inflammatory responses: evidence from the heme oxygenase-1-deficient mouse.
The American journal of pathology Sep, 2004 | Pubmed ID: 15331427
Diabetes acceleration or prevention by a coxsackievirus B4 infection: critical requirements for both interleukin-4 and gamma interferon.
Journal of virology Jan, 2005 | Pubmed ID: 15613333
Efficient transduction of vascular endothelial cells with recombinant adeno-associated virus serotype 1 and 5 vectors.
Human gene therapy Feb, 2005 | Pubmed ID: 15761263
Interleukin 10 attenuates neointimal proliferation and inflammation in aortic allografts by a heme oxygenase-dependent pathway.
Proceedings of the National Academy of Sciences of the United States of America May, 2005 | Pubmed ID: 15878989
Localized gene expression following administration of adeno-associated viral vectors via pancreatic ducts.
Molecular therapy : the journal of the American Society of Gene Therapy Sep, 2005 | Pubmed ID: 15979413
Efficient hepatic delivery and expression from a recombinant adeno-associated virus 8 pseudotyped alpha1-antitrypsin vector.
Molecular therapy : the journal of the American Society of Gene Therapy Nov, 2005 | Pubmed ID: 16085464
Successful production of pseudotyped rAAV vectors using a modified baculovirus expression system.
Molecular therapy : the journal of the American Society of Gene Therapy Dec, 2005 | Pubmed ID: 16213797
Therapeutic level of functional human alpha 1 antitrypsin (hAAT) secreted from murine muscle transduced by adeno-associated virus (rAAV1) vector.
The journal of gene medicine Jun, 2006 | Pubmed ID: 16518879
Alpha1-antitrypsin gene therapy modulates cellular immunity and efficiently prevents type 1 diabetes in nonobese diabetic mice.
Human gene therapy Jun, 2006 | Pubmed ID: 16776571
Cystic fibrosis transmembrane conductance regulator deficiency exacerbates islet cell dysfunction after beta-cell injury.
Diabetes Jul, 2006 | Pubmed ID: 16804061
Noninvasive imaging of islet grafts using positron-emission tomography.
Proceedings of the National Academy of Sciences of the United States of America Jul, 2006 | Pubmed ID: 16868090
Diabetic endothelial nitric oxide synthase knockout mice develop advanced diabetic nephropathy.
Journal of the American Society of Nephrology : JASN Feb, 2007 | Pubmed ID: 17202420
Alpha1-antitrypsin protects beta-cells from apoptosis.
Diabetes May, 2007 | Pubmed ID: 17360983
Preclinical characterization of a recombinant adeno-associated virus type 1-pseudotyped vector demonstrates dose-dependent injection site inflammation and dissemination of vector genomes to distant sites.
Human gene therapy Mar, 2007 | Pubmed ID: 17376008
In vitro studies of steroid hormones in neurofibromatosis 1 tumors and Schwann cells.
Molecular carcinogenesis Jul, 2007 | Pubmed ID: 17393410
Ectopic expression of Wnt10b decreases adiposity and improves glucose homeostasis in obese rats.
American journal of physiology. Endocrinology and metabolism Sep, 2007 | Pubmed ID: 17578883
In vivo post-transcriptional gene silencing of alpha-1 antitrypsin by adeno-associated virus vectors expressing siRNA.
Laboratory investigation; a journal of technical methods and pathology Sep, 2007 | Pubmed ID: 17592477
Distinct expression and activity profiles of largemouth bass (Micropterus salmoides) estrogen receptors in response to estradiol and nonylphenol.
Journal of molecular endocrinology Oct, 2007 | Pubmed ID: 17909263
Gene delivery to intestinal epithelial cells in vitro and in vivo with recombinant adeno-associated virus types 1, 2 and 5.
Digestive diseases and sciences May, 2008 | Pubmed ID: 17934813
p53 regulates FAK expression in human tumor cells.
Molecular carcinogenesis May, 2008 | Pubmed ID: 17999388
Partial correction of the CFTR-dependent ABPA mouse model with recombinant adeno-associated virus gene transfer of truncated CFTR gene.
The journal of gene medicine Jan, 2008 | Pubmed ID: 18023072
Murine antithymocyte globulin therapy alters disease progression in NOD mice by a time-dependent induction of immunoregulation.
Diabetes Feb, 2008 | Pubmed ID: 18039815
Biochemical correction of short-chain acyl-coenzyme A dehydrogenase deficiency after portal vein injection of rAAV8-SCAD.
Human gene therapy Jun, 2008 | Pubmed ID: 18500942
The pivotal role of VEGF on glomerular macrophage infiltration in advanced diabetic nephropathy.
Laboratory investigation; a journal of technical methods and pathology Sep, 2008 | Pubmed ID: 18607348
Recombinant adeno-associated virus-mediated gene delivery of long chain acyl coenzyme A dehydrogenase (LCAD) into LCAD-deficient mice.
The journal of gene medicine Oct, 2008 | Pubmed ID: 18720429
Recombinant AAV serotype and capsid mutant comparison for pulmonary gene transfer of alpha-1-antitrypsin using invasive and noninvasive delivery.
Molecular therapy : the journal of the American Society of Gene Therapy Jan, 2009 | Pubmed ID: 18941444
Endothelial injury due to eNOS deficiency accelerates the progression of chronic renal disease in the mouse.
American journal of physiology. Renal physiology Feb, 2009 | Pubmed ID: 19036847
Exendin-4 therapy in NOD mice with new-onset diabetes increases regulatory T cell frequency.
Annals of the New York Academy of Sciences Dec, 2008 | Pubmed ID: 19120286
Exendin-4 treatment of nonobese diabetic mice increases beta-cell proliferation and fractional insulin reactive area.
Journal of diabetes and its complications May-Jun, 2010 | Pubmed ID: 19217320
Lowering blood pressure blocks mesangiolysis and mesangial nodules, but not tubulointerstitial injury, in diabetic eNOS knockout mice.
The American journal of pathology Apr, 2009 | Pubmed ID: 19246639
Rabbit polyclonal mouse antithymocyte globulin administration alters dendritic cell profile and function in NOD mice to suppress diabetogenic responses.
Journal of immunology (Baltimore, Md. : 1950) Apr, 2009 | Pubmed ID: 19342635
Immune depletion with cellular mobilization imparts immunoregulation and reverses autoimmune diabetes in nonobese diabetic mice.
Diabetes Oct, 2009 | Pubmed ID: 19628781
Combination of alpha-1 antitrypsin and doxycycline suppresses collagen-induced arthritis.
The journal of gene medicine Jan, 2010 | Pubmed ID: 19866480
Soluble Flt-1 gene therapy ameliorates albuminuria but accelerates tubulointerstitial injury in diabetic mice.
American journal of physiology. Renal physiology Mar, 2010 | Pubmed ID: 20015944
Gel-mediated delivery of AAV1 vectors corrects ventilatory function in Pompe mice with established disease.
Molecular therapy : the journal of the American Society of Gene Therapy Mar, 2010 | Pubmed ID: 20104213
Adeno-associated virus-mediated correction of a canine model of glycogen storage disease type Ia.
Human gene therapy Jul, 2010 | Pubmed ID: 20163245
Endothelial von Willebrand factor release due to eNOS deficiency predisposes to thrombotic microangiopathy in mouse aging kidney.
The American journal of pathology May, 2010 | Pubmed ID: 20363914
Diabetic eNOS-knockout mice develop accelerated retinopathy.
Investigative ophthalmology & visual science Oct, 2010 | Pubmed ID: 20435587
The pancreas in human type 1 diabetes.
Seminars in immunopathology Jan, 2011 | Pubmed ID: 20495921
Ex vivo transduction and transplantation of bone marrow cells for liver gene delivery of alpha1-antitrypsin.
Molecular therapy : the journal of the American Society of Gene Therapy Aug, 2010 | Pubmed ID: 20551917
N-glycosylation augmentation of the cystic fibrosis epithelium improves Pseudomonas aeruginosa clearance.
American journal of respiratory cell and molecular biology Jun, 2011 | Pubmed ID: 20693405
Analysis of steroid hormone effects on xenografted human NF1 tumor schwann cells.
Cancer biology & therapy Oct, 2010 | Pubmed ID: 20699653
Glycogen storage disease type Ia in canines: a model for human metabolic and genetic liver disease.
Journal of biomedicine & biotechnology , 2011 | Pubmed ID: 21318173
Alpha-1 antitrypsin protein and gene therapies decrease autoimmunity and delay arthritis development in mouse model.
Journal of translational medicine , 2011 | Pubmed ID: 21345239
Selective stimulation of VEGFR2 accelerates progressive renal disease.
The American journal of pathology Jul, 2011 | Pubmed ID: 21640973
Enhanced expression of Pctk1, Tcf12 and Ccnd1 in hippocampus of rats: Impact on cognitive function, synaptic plasticity and pathology.
Neurobiology of learning and memory Jan, 2012 | Pubmed ID: 21982980
Salivary PYY: a putative bypass to satiety.
PloS one , 2011 | Pubmed ID: 22028819
Network for Pancreatic Organ Donors with Diabetes (nPOD): developing a tissue biobank for type 1 diabetes.
Diabetes/metabolism research and reviews Oct, 2012 | Pubmed ID: 22585677
Pancreas organ weight in individuals with disease-associated autoantibodies at risk for type 1 diabetes.
JAMA Dec, 2012 | Pubmed ID: 23232891
Marked expansion of exocrine and endocrine pancreas with incretin therapy in humans with increased exocrine pancreas dysplasia and the potential for glucagon-producing neuroendocrine tumors.
Diabetes Jul, 2013 | Pubmed ID: 23524641
Increased complement activation in human type 1 diabetes pancreata.
Diabetes care Nov, 2013 | Pubmed ID: 24041678
Response to comments on: Butler et al. Marked expansion of exocrine and endocrine pancreas with incretin therapy in humans with increased exocrine pancreas dysplasia and the potential for glucagon-producing neuroendocrine tumors. Diabetes 2013;62:2595-2604.
Diabetes Oct, 2013 | Pubmed ID: 24065800
Human Treg responses allow sustained recombinant adeno-associated virus-mediated transgene expression.
The Journal of clinical investigation Dec, 2013 | Pubmed ID: 24231351
The Juvenile Diabetes Research Foundation Network for Pancreatic Organ Donors with Diabetes (nPOD) Program: goals, operational model and emerging findings.
Pediatric diabetes Feb, 2014 | Pubmed ID: 24325575
New insight on human type 1 diabetes biology: nPOD and nPOD-transplantation.
Current diabetes reports Oct, 2014 | Pubmed ID: 25142715
Organ donor specimens: What can they tell us about type 1 diabetes?
Pediatric diabetes Aug, 2015 | Pubmed ID: 25998576
Combination Therapy Reverses Hyperglycemia in NOD Mice With Established Type 1 Diabetes.
Diabetes Nov, 2015 | Pubmed ID: 26185279
A combination hydrogel microparticle-based vaccine prevents type 1 diabetes in non-obese diabetic mice.
Scientific reports Aug, 2015 | Pubmed ID: 26279095
Proteomic Analysis of Disease Stratified Human Pancreas Tissue Indicates Unique Signature of Type 1 Diabetes.
PloS one , 2015 | Pubmed ID: 26302420
Abnormalities of the Exocrine Pancreas in Type 1 Diabetes.
Current diabetes reports Oct, 2015 | Pubmed ID: 26318606
The influence of type 1 diabetes on pancreatic weight.
Diabetologia Jan, 2016 | Pubmed ID: 26358584
Beyond the brain: disrupted in schizophrenia 1 regulates pancreatic β-cell function via glycogen synthase kinase-3β.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Feb, 2016 | Pubmed ID: 26546129
Insulitis and β-Cell Mass in the Natural History of Type 1 Diabetes.
Diabetes Mar, 2016 | Pubmed ID: 26581594
Pancreatic duct hyperplasia/dysplasia in type 1 diabetes and pancreatic weight in individuals with and without diabetes. Reply to Kobayashi T, Aida K, Fukui T et al [letter] and Saisho Y [letter].
Diabetologia Apr, 2016 | Pubmed ID: 26861059
Relative sensitivity of immunohistochemistry, multiple reaction monitoring mass spectrometry, in situ hybridization and PCR to detect Coxsackievirus B1 in A549 cells.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology Apr, 2016 | Pubmed ID: 26875099
Presumptive Type 1 Diabetes With Comorbidities and Rapid Progression Despite Numerous Insulin-Positive Islets.
Diabetes care 07, 2016 | Pubmed ID: 27330131
Aberrant Menin expression is an early event in pancreatic neuroendocrine tumorigenesis.
Human pathology 10, 2016 | Pubmed ID: 27342911
Diagnostic Dilemma: Clinical and Histological Abnormalities in a Hispanic Patient With Diabetes.
Diabetes care 09, 2016 | Pubmed ID: 27555624
Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes.
Nature medicine Dec, 2016 | Pubmed ID: 27798614
Islet-derived CD4 T-cells targeting proinsulin in human autoimmune diabetes.
Diabetes Dec, 2016 | Pubmed ID: 27920090
Tissue distribution and clonal diversity of the T and B cell repertoire in type 1 diabetes.
JCI insight Dec, 2016 | Pubmed ID: 27942583
Factors That Influence the Quality of RNA From the Pancreas of Organ Donors.
Pancreas Feb, 2017 | Pubmed ID: 27984510
Re-addressing the 2013 consensus guidelines for the diagnosis of insulitis in human type 1 diabetes: is change necessary?
Diabetologia Apr, 2017 | Pubmed ID: 28070616
Serum Trypsinogen Levels in Type 1 Diabetes.
Diabetes care 04, 2017 | Pubmed ID: 28115475
5 Year Expression and Neutrophil Defect Repair after Gene Therapy in Alpha-1 Antitrypsin Deficiency.
Molecular therapy : the journal of the American Society of Gene Therapy Jun, 2017 | Pubmed ID: 28408179
Insulitis in Autoantibody-Positive Pancreatic Donor With History of Gestational Diabetes Mellitus.
Diabetes care 05, 2017 | Pubmed ID: 28428323
High Illicit Drug Abuse and Suicide in Organ Donors With Type 1 Diabetes.
Diabetes care Sep, 2017 | Pubmed ID: 28679687
Immunohistochemistry Staining for Human Alpha-1 Antitrypsin.
Methods in molecular biology (Clifton, N.J.) , 2017 | Pubmed ID: 28752453
Periodic Acid-Schiff Staining with Diastase.
Methods in molecular biology (Clifton, N.J.) , 2017 | Pubmed ID: 28752454
Persistence of Pancreatic Insulin mRNA Expression and Proinsulin Protein in Type 1 Diabetes Pancreata.
Cell metabolism Sep, 2017 | Pubmed ID: 28877460
Response to Comment on Jackson et al. Insulitis in Autoantibody-Positive Pancreatic Donor With History of Gestational Diabetes Mellitus. Diabetes Care 2017;40:723-725.
Diabetes care Oct, 2017 | Pubmed ID: 28931713
Pancreatic Histopathology of Human Monogenic Diabetes Due to Causal Variants in KCNJ11, HNF1A, GATA6, and LMNA.
The Journal of clinical endocrinology and metabolism Jan, 2018 | Pubmed ID: 28938416
Elizabeth Butterworth1,
Wesley Dickerson2,
Vindhya Vijay3,
Kristina Weitzel1,
Julia Cooper1,
Eric W. Atkinson4,
Jason E. Coleman5,
Kevin J. Otto4,
Martha Campbell-Thompson1
1Department of Pathology, Immunology and Experimental Medicine, University of Florida,
2Heller School for Social Policy and Management, Brandeis University,
3Department of Medicine, College of Medicine, University of Florida,
4Department of Biomedical Engineering, College of Engineering, University of Florida,
5Department of Pediatrics, College of Medicine, University of Florida
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