Department of Microbiology,
Immunology,
and Pathology,
Department of Microbiology, Immunology, and Pathology,
Mycobacteria Research Laboratories,
Mycobacteria Research Laboratories, Department of Microbiology, Immunology, and Pathology
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In vivo IL-10 production reactivates chronic pulmonary tuberculosis in C57BL/6 mice.
Journal of immunology (Baltimore, Md. : 1950) Dec, 2002 | Pubmed ID: 12444141
Florid pulmonary inflammatory responses in mice vaccinated with Antigen-85 pulsed dendritic cells and challenged by aerosol with Mycobacterium tuberculosis.
Cellular immunology Nov, 2002 | Pubmed ID: 12718935
Dynamics of macrophage cell populations during murine pulmonary tuberculosis.
Journal of immunology (Baltimore, Md. : 1950) Sep, 2003 | Pubmed ID: 12960339
NK cells respond to pulmonary infection with Mycobacterium tuberculosis, but play a minimal role in protection.
Journal of immunology (Baltimore, Md. : 1950) Dec, 2003 | Pubmed ID: 14634116
Stable T-cell population expressing an effector cell surface phenotype in the lungs of mice chronically infected with Mycobacterium tuberculosis.
Infection and immunity Jan, 2004 | Pubmed ID: 14688138
Disruption of granulocyte macrophage-colony stimulating factor production in the lungs severely affects the ability of mice to control Mycobacterium tuberculosis infection.
Journal of leukocyte biology Jun, 2005 | Pubmed ID: 15767289
Interleukin-10 production by lung macrophages in CBA xid mutant mice infected with Mycobacterium tuberculosis.
Immunology Jun, 2005 | Pubmed ID: 15885131
Factors associated with severe granulomatous pneumonia in Mycobacterium tuberculosis-infected mice vaccinated therapeutically with hsp65 DNA.
Infection and immunity Aug, 2005 | Pubmed ID: 16041037
Foamy macrophages within lung granulomas of mice infected with Mycobacterium tuberculosis express molecules characteristic of dendritic cells and antiapoptotic markers of the TNF receptor-associated factor family.
Journal of immunology (Baltimore, Md. : 1950) Sep, 2005 | Pubmed ID: 16148133
Virulent clinical isolates of Mycobacterium tuberculosis grow rapidly and induce cellular necrosis but minimal apoptosis in murine macrophages.
Journal of leukocyte biology Jan, 2006 | Pubmed ID: 16275894
Enhanced macrophage activity in granulomatous lesions of immune mice challenged with Mycobacterium tuberculosis.
Journal of immunology (Baltimore, Md. : 1950) Apr, 2006 | Pubmed ID: 16585589
Cross-reaction of anti-human CD monoclonal antibodies on guinea pig cells: a summary of the guinea pig section of the HLDA8 animal homologues data.
Veterinary immunology and immunopathology Sep, 2007 | Pubmed ID: 17658620
XCL1 (lymphotactin) chemokine produced by activated CD8 T cells during the chronic stage of infection with Mycobacterium tuberculosis negatively affects production of IFN-gamma by CD4 T cells and participates in granuloma stability.
Journal of leukocyte biology Nov, 2007 | Pubmed ID: 17699612
Relative levels of M-CSF and GM-CSF influence the specific generation of macrophage populations during infection with Mycobacterium tuberculosis.
Journal of immunology (Baltimore, Md. : 1950) Apr, 2008 | Pubmed ID: 18354213
Phenotypic non-equivalence of murine (monocyte-) macrophage cells in biomaterial and inflammatory models.
Journal of biomedical materials research. Part A Mar, 2009 | Pubmed ID: 18357567
Animal models of M. tuberculosis Infection.
Current protocols in microbiology Nov, 2007 | Pubmed ID: 18770606
Immune response to Mycobacterium tuberculosis and identification of molecular markers of disease.
American journal of respiratory cell and molecular biology Apr, 2009 | Pubmed ID: 18787176
Interleukin-10 promotes Mycobacterium tuberculosis disease progression in CBA/J mice.
Journal of immunology (Baltimore, Md. : 1950) Oct, 2008 | Pubmed ID: 18832712
Intrapulmonary delivery of XCL1-targeting small interfering RNA in mice chronically infected with Mycobacterium tuberculosis.
American journal of respiratory cell and molecular biology Aug, 2009 | Pubmed ID: 19097989
Lack of IL-10 alters inflammatory and immune responses during pulmonary Mycobacterium tuberculosis infection.
Tuberculosis (Edinburgh, Scotland) Mar, 2009 | Pubmed ID: 19213603
Localized immunosuppressive environment in the foreign body response to implanted biomaterials.
The American journal of pathology Jul, 2009 | Pubmed ID: 19528351
Differential polarization of alveolar macrophages and bone marrow-derived monocytes following chemically and pathogen-induced chronic lung inflammation.
Journal of leukocyte biology Jul, 2010 | Pubmed ID: 20360403
Multiple M. tuberculosis phenotypes in mouse and guinea pig lung tissue revealed by a dual-staining approach.
PloS one , 2010 | Pubmed ID: 20559431
Optimization of inhaled therapies for tuberculosis: the role of macrophages and dendritic cells.
Tuberculosis (Edinburgh, Scotland) Jan, 2011 | Pubmed ID: 20888298
Local pulmonary immunotherapy with siRNA targeting TGFβ1 enhances antimicrobial capacity in Mycobacterium tuberculosis infected mice.
Tuberculosis (Edinburgh, Scotland) Jan, 2011 | Pubmed ID: 21195670
Glycolytic and non-glycolytic functions of Mycobacterium tuberculosis fructose-1,6-bisphosphate aldolase, an essential enzyme produced by replicating and non-replicating bacilli.
The Journal of biological chemistry Nov, 2011 | Pubmed ID: 21949126
Characterization of murine lung dendritic cells infected with Mycobacterium tuberculosis.
Infection and immunity Feb, 2001 | Pubmed ID: 11160010
Temporal and spatial arrangement of lymphocytes within lung granulomas induced by aerosol infection with Mycobacterium tuberculosis.
Infection and immunity Mar, 2001 | Pubmed ID: 11179349
Immunity to TB and targets for immunotherapy.
Immunotherapy Feb, 2012 | Pubmed ID: 22339461
Mouse model for efficacy testing of antituberculosis agents via intrapulmonary delivery.
Antimicrobial agents and chemotherapy Jul, 2012 | Pubmed ID: 22547626
Exposure to a cutinase-like serine esterase triggers rapid lysis of multiple mycobacterial species.
The Journal of biological chemistry Jan, 2013 | Pubmed ID: 23155047
Experimental aerosol Mycobacterium bovis model of infection in goats.
Tuberculosis (Edinburgh, Scotland) Sep, 2013 | Pubmed ID: 23850102
Correlates of immune protection following cutaneous immunization with an attenuated Burkholderia pseudomallei vaccine.
Infection and immunity Dec, 2013 | Pubmed ID: 24101688
GM-CSF knockout mice for preclinical testing of agents with antimicrobial activity against Mycobacterium abscessus.
The Journal of antimicrobial chemotherapy Apr, 2014 | Pubmed ID: 24222613
Polar lipids of Burkholderia pseudomallei induce different host immune responses.
PloS one , 2013 | Pubmed ID: 24260378
Spectinamides: a new class of semisynthetic antituberculosis agents that overcome native drug efflux.
Nature medicine Feb, 2014 | Pubmed ID: 24464186
Microhemorrhage is an early event in the pulmonary fibrotic disease of PECAM-1 deficient FVB/n mice.
Experimental and molecular pathology Aug, 2014 | Pubmed ID: 24972347
Long-term survival and virulence of Mycobacterium leprae in amoebal cysts.
PLoS neglected tropical diseases Dec, 2014 | Pubmed ID: 25521850
Extended culture of macrophages from different sources and maturation results in a common M2 phenotype.
Journal of biomedical materials research. Part A Sep, 2015 | Pubmed ID: 25684281
Presence of multiple lesion types with vastly different microenvironments in C3HeB/FeJ mice following aerosol infection with Mycobacterium tuberculosis.
Disease models & mechanisms Jun, 2015 | Pubmed ID: 26035867
Partial Saturation of Menaquinone in : Function and Essentiality of a Novel Reductase, MenJ.
ACS central science Sep, 2015 | Pubmed ID: 26436137
Potential and development of inhaled RNAi therapeutics for the treatment of pulmonary tuberculosis.
Advanced drug delivery reviews 07, 2016 | Pubmed ID: 27108702
Therapeutic Potential of the Mycobacterium tuberculosis Mycolic Acid Transporter, MmpL3.
Antimicrobial agents and chemotherapy Sep, 2016 | Pubmed ID: 27297488
Mycobacterium bovis hosted by free-living-amoebae permits their long-term persistence survival outside of host mammalian cells and remain capable of transmitting disease to mice.
Environmental microbiology Oct, 2017 | Pubmed ID: 28585299
The minipig as an animal model to study Mycobacterium tuberculosis infection and natural transmission.
Tuberculosis (Edinburgh, Scotland) Sep, 2017 | Pubmed ID: 28802411
Evaluation of shedding, tissue burdens, and humoral immune response in goats after experimental challenge with the virulent Brucella melitensis strain 16M and the reduced virulence vaccine strain Rev. 1.
PloS one , 2017 | Pubmed ID: 29028813
Yersinia pestis Survival and Replication in Potential Ameba Reservoir.
Emerging infectious diseases Feb, 2018 | Pubmed ID: 29350155
Evidence of zoonotic leprosy in Pará, Brazilian Amazon, and risks associated with human contact or consumption of armadillos.
PLoS neglected tropical diseases Jun, 2018 | Pubmed ID: 29953440
Cell mediated immune response in goats after experimental challenge with the virulent Brucella melitensis strain 16M and the reduced virulence strain Rev. 1.
Veterinary immunology and immunopathology Aug, 2018 | Pubmed ID: 30078602
Interactions of free-living amoebae with rice bacterial pathogens Xanthomonas oryzae pathovars oryzae and oryzicola.
PloS one , 2018 | Pubmed ID: 30142182
Primary Lung Dendritic Cell Cultures to Assess Efficacy of Spectinamide-1599 Against Intracellular .
Frontiers in microbiology , 2018 | Pubmed ID: 30186246
Optimization and Lead Selection of Benzothiazole Amide Analogs Toward a Novel Antimycobacterial Agent.
Frontiers in microbiology , 2018 | Pubmed ID: 30294313
Host Directed Therapy for Chronic Tuberculosis via Intrapulmonary Delivery of Aerosolized Peptide Inhibitors Targeting the IL-10-STAT3 Pathway.
Scientific reports Nov, 2018 | Pubmed ID: 30413750
Comparative pharmacokinetics of spectinamide 1599 after subcutaneous and intrapulmonary aerosol administration in mice.
Tuberculosis (Edinburgh, Scotland) Jan, 2019 | Pubmed ID: 30711150
Direct Inhibition of MmpL3 by Novel Antitubercular Compounds.
ACS infectious diseases Jun, 2019 | Pubmed ID: 30882198
Development and Characterization of a Dry Powder Formulation for Anti-Tuberculosis Drug Spectinamide 1599.
Pharmaceutical research Jul, 2019 | Pubmed ID: 31321552
Sterilization of Mycobacterium tuberculosis infected samples using methanol preserves anti-tuberculosis drugs for subsequent pharmacological testing studies.
Tuberculosis (Edinburgh, Scotland) Jul, 2019 | Pubmed ID: 31378268
Minipigs as a neonatal animal model for tuberculosis vaccine efficacy testing.
Veterinary immunology and immunopathology Sep, 2019 | Pubmed ID: 31420066
Inhaled tigecycline is effective against Mycobacterium abscessus in vitro and in vivo.
The Journal of antimicrobial chemotherapy Jul, 2020 | Pubmed ID: 32294173
Neonatal and infant immunity for tuberculosis vaccine development: importance of age-matched animal models.
Disease models & mechanisms Sep, 2020 | Pubmed ID: 32988990
Preclinical Evaluation of Inhalational Spectinamide-1599 Therapy against Tuberculosis.
ACS infectious diseases Oct, 2021 | Pubmed ID: 34546724
Lipid nanoparticle formulation of niclosamide (nano NCM) effectively inhibits SARS-CoV-2 replication .
Precision nanomedicine Apr, 2021 | Pubmed ID: 34676370
Unique Features of Biofilms Formed in Synthetic Cystic Fibrosis Medium.
Frontiers in microbiology , 2021 | Pubmed ID: 34777289
Therapeutic efficacy of antimalarial drugs targeting DosRS signaling in .
Science translational medicine Feb, 2022 | Pubmed ID: 35196022
Mycobacterium leprae Infection in a Wild Nine-Banded Armadillo, Nuevo León, Mexico.
Emerging infectious diseases Mar, 2022 | Pubmed ID: 35202538
Development of a Mucoadhesive Liquid Crystal System for the Administration of Rifampicin Applicable in Tuberculosis Therapy.
Life (Basel, Switzerland) Jul, 2022 | Pubmed ID: 36013317
Microbiological profile, preclinical pharmacokinetics and efficacy of CRS0393, a novel antimycobacterial agent targeting MmpL3.
Tuberculosis (Edinburgh, Scotland) Jan, 2023 | Pubmed ID: 36470124
Mucosal exposure to non-tuberculous mycobacteria elicits B cell-mediated immunity against pulmonary tuberculosis.
Cell reports Dec, 2022 | Pubmed ID: 36516760
Spray dried tigecycline dry powder aerosols for the treatment of Nontuberculous mycobacterial pulmonary infections.
Tuberculosis (Edinburgh, Scotland) Mar, 2023 | Pubmed ID: 36716525
Characterization of spectinamide 1599 efficacy against different mycobacterial phenotypes.
Tuberculosis (Edinburgh, Scotland) May, 2023 | Pubmed ID: 37120915
Intrapulmonary Treatment with Mycobacteriophage LysB Rapidly Reduces Mycobacterium abscessus Burden.
Antimicrobial agents and chemotherapy Jun, 2023 | Pubmed ID: 37154689
Development of a Minimalistic Physiologically Based Pharmacokinetic (mPBPK) Model for the Preclinical Development of Spectinamide Antibiotics.
Pharmaceutics Jun, 2023 | Pubmed ID: 37376207
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