Department of Neurology
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Focal loss of the glutamate transporter EAAT2 in a transgenic rat model of SOD1 mutant-mediated amyotrophic lateral sclerosis (ALS).
Proceedings of the National Academy of Sciences of the United States of America Feb, 2002 | Pubmed ID: 11818550
Amyotrophic lateral sclerosis: pathogenesis, differential diagnoses, and potential interventions.
The journal of spinal cord medicine , 2002 | Pubmed ID: 12482167
Topiramate protects against motor neuron degeneration in organotypic spinal cord cultures but not in G93A SOD1 transgenic mice.
Neuroscience letters Feb, 2003 | Pubmed ID: 12566164
Human embryonic germ cell derivatives facilitate motor recovery of rats with diffuse motor neuron injury.
The Journal of neuroscience : the official journal of the Society for Neuroscience Jun, 2003 | Pubmed ID: 12832537
Glutamate transporter expression and function in human glial progenitors.
Glia Jan, 2004 | Pubmed ID: 14730707
Altered expression of the glutamate transporter EAAT2b in neurological disease.
Annals of neurology Apr, 2004 | Pubmed ID: 15048885
Glutamate transporters: animal models to neurologic disease.
Neurobiology of disease Apr, 2004 | Pubmed ID: 15056453
Viral-induced spinal motor neuron death is non-cell-autonomous and involves glutamate excitotoxicity.
The Journal of neuroscience : the official journal of the Society for Neuroscience Aug, 2004 | Pubmed ID: 15329404
Neural stem cells protect against glutamate-induced excitotoxicity and promote survival of injured motor neurons through the secretion of neurotrophic factors.
Molecular and cellular neurosciences Nov, 2004 | Pubmed ID: 15519246
Glial restricted precursors protect against chronic glutamate neurotoxicity of motor neurons in vitro.
Glia Apr, 2005 | Pubmed ID: 15657939
Degeneration of respiratory motor neurons in the SOD1 G93A transgenic rat model of ALS.
Neurobiology of disease Jan, 2006 | Pubmed ID: 16084734
Selective up-regulation of the glial Na+-dependent glutamate transporter GLT1 by a neuroimmunophilin ligand results in neuroprotection.
Neurobiology of disease Mar, 2006 | Pubmed ID: 16274998
Loss of the astrocyte glutamate transporter GLT1 modifies disease in SOD1(G93A) mice.
Experimental neurology Sep, 2006 | Pubmed ID: 16753145
Mechanisms of Disease: astrocytes in neurodegenerative disease.
Nature clinical practice. Neurology Dec, 2006 | Pubmed ID: 17117171
Intraparenchymal spinal cord delivery of adeno-associated virus IGF-1 is protective in the SOD1G93A model of ALS.
Brain research Dec, 2007 | Pubmed ID: 17963733
Selective ablation of proliferating astrocytes does not affect disease outcome in either acute or chronic models of motor neuron degeneration.
Experimental neurology Jun, 2008 | Pubmed ID: 18410928
Focal transplantation-based astrocyte replacement is neuroprotective in a model of motor neuron disease.
Nature neuroscience Nov, 2008 | Pubmed ID: 18931666
Accurate ALSFRS-R scores can be generated from retrospective review of clinic notes.
Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases Aug, 2009 | Pubmed ID: 18985465
Rethinking a drug treatment failure on a traditional ALS target.
Experimental neurology Apr, 2009 | Pubmed ID: 19309797
A targeted neuroglial reporter line generated by homologous recombination in human embryonic stem cells.
Stem cells (Dayton, Ohio) Aug, 2009 | Pubmed ID: 19544414
Advances in stem cell research for Amyotrophic Lateral Sclerosis.
Current opinion in biotechnology Oct, 2009 | Pubmed ID: 19819686
Peripheral hyperstimulation alters site of disease onset and course in SOD1 rats.
Neurobiology of disease Sep, 2010 | Pubmed ID: 20381620
Stem cells and the ALS neurologist.
Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases Oct, 2010 | Pubmed ID: 20509745
Spatial and temporal changes in promoter activity of the astrocyte glutamate transporter GLT1 following traumatic spinal cord injury.
Journal of neuroscience research Jul, 2011 | Pubmed ID: 21488085
Reduction in expression of the astrocyte glutamate transporter, GLT1, worsens functional and histological outcomes following traumatic spinal cord injury.
Glia Aug, 2011 | Pubmed ID: 21882244
Stem cell transplantation for spinal cord neurodegeneration.
Methods in molecular biology (Clifton, N.J.) , 2011 | Pubmed ID: 21913120
Astrocytes carrying the superoxide dismutase 1 (SOD1G93A) mutation induce wild-type motor neuron degeneration in vivo.
Proceedings of the National Academy of Sciences of the United States of America Oct, 2011 | Pubmed ID: 21969586
Human glial-restricted progenitor transplantation into cervical spinal cord of the SOD1 mouse model of ALS.
PloS one , 2011 | Pubmed ID: 21998733
Selective increase of two ABC drug efflux transporters at the blood-spinal cord barrier suggests induced pharmacoresistance in ALS.
Neurobiology of disease Aug, 2012 | Pubmed ID: 22521463
Creation of an open-access, mutation-defined fibroblast resource for neurological disease research.
PloS one , 2012 | Pubmed ID: 22952635
Glia: an emerging target for neurological disease therapy.
Stem cell research & therapy Sep, 2012 | Pubmed ID: 23021042
Exome sequencing to identify de novo mutations in sporadic ALS trios.
Nature neuroscience Jul, 2013 | Pubmed ID: 23708140
Altered astrocytic expression of TDP-43 does not influence motor neuron survival.
Experimental neurology Dec, 2013 | Pubmed ID: 24120466
C9orf72 nucleotide repeat structures initiate molecular cascades of disease.
Nature Mar, 2014 | Pubmed ID: 24598541
Gene profiling of human induced pluripotent stem cell-derived astrocyte progenitors following spinal cord engraftment.
Stem cells translational medicine May, 2014 | Pubmed ID: 24604284
Induced pluripotent stem cells from ALS patients for disease modeling.
Brain research May, 2015 | Pubmed ID: 25223906
Transplantation of glial progenitors that overexpress glutamate transporter GLT1 preserves diaphragm function following cervical SCI.
Molecular therapy : the journal of the American Society of Gene Therapy Mar, 2015 | Pubmed ID: 25492561
Human glial progenitor engraftment and gene expression is independent of the ALS environment.
Experimental neurology Feb, 2015 | Pubmed ID: 25523812
Peripheral neuropathy in a family with Sandhoff disease and SH3TC2 deficiency.
Journal of neurology , 2015 | Pubmed ID: 25736553
A comprehensive library of familial human amyotrophic lateral sclerosis induced pluripotent stem cells.
PloS one , 2015 | Pubmed ID: 25760436
Neural and glial progenitor transplantation as a neuroprotective strategy for Amyotrophic Lateral Sclerosis (ALS).
Brain research Dec, 2015 | Pubmed ID: 26187754
Human iPS cell-derived astrocyte transplants preserve respiratory function after spinal cord injury.
Experimental neurology Sep, 2015 | Pubmed ID: 26216662
Generation of GFAP::GFP astrocyte reporter lines from human adult fibroblast-derived iPS cells using zinc-finger nuclease technology.
Glia Jan, 2016 | Pubmed ID: 26295203
Hemiparetic Primary Lateral Sclerosis: Revisiting Mills Syndrome.
Case reports in neurology Sep-Dec, 2015 | Pubmed ID: 26500542
Primary Lateral Sclerosis and Early Upper Motor Neuron Disease: Characteristics of a Cross-Sectional Population.
Journal of clinical neuromuscular disease Mar, 2016 | Pubmed ID: 26905909
Connexin 43 in astrocytes contributes to motor neuron toxicity in amyotrophic lateral sclerosis.
Glia 07, 2016 | Pubmed ID: 27083773
Astrocytes drive upregulation of the multidrug resistance transporter ABCB1 (P-Glycoprotein) in endothelial cells of the blood-brain barrier in mutant superoxide dismutase 1-linked amyotrophic lateral sclerosis.
Glia 08, 2016 | Pubmed ID: 27158936
Defining SOD1 ALS natural history to guide therapeutic clinical trial design.
Journal of neurology, neurosurgery, and psychiatry Feb, 2017 | Pubmed ID: 27261500
Serial in vivo imaging of transplanted allogeneic neural stem cell survival in a mouse model of amyotrophic lateral sclerosis.
Experimental neurology 03, 2017 | Pubmed ID: 28038988
Sporadic ALS Astrocytes Induce Neuronal Degeneration In Vivo.
Stem cell reports 04, 2017 | Pubmed ID: 28366455
MicroRNA Profiling Reveals Marker of Motor Neuron Disease in ALS Models.
The Journal of neuroscience : the official journal of the Society for Neuroscience 05, 2017 | Pubmed ID: 28416596
Motoneuron Disease: Basic Science.
Advances in neurobiology , 2017 | Pubmed ID: 28674981
Motoneuron Disease: Clinical.
Advances in neurobiology , 2017 | Pubmed ID: 28674982
What can we learn from the edaravone development program for ALS?
Amyotrophic lateral sclerosis & frontotemporal degeneration Oct, 2017 | Pubmed ID: 28872911
Erratum.
Advances in neurobiology , 2017 | Pubmed ID: 28905310
Fibroblast bioenergetics to classify amyotrophic lateral sclerosis patients.
Molecular neurodegeneration 10, 2017 | Pubmed ID: 29065921
A randomized controlled trial of resistance and endurance exercise in amyotrophic lateral sclerosis.
Amyotrophic lateral sclerosis & frontotemporal degeneration 05, 2018 | Pubmed ID: 29191052
Genome-wide Analyses Identify KIF5A as a Novel ALS Gene.
Neuron Mar, 2018 | Pubmed ID: 29566793
A stocked toolbox for understanding the role of astrocytes in disease.
Nature reviews. Neurology 06, 2018 | Pubmed ID: 29769699
Motor neuron-derived microRNAs cause astrocyte dysfunction in amyotrophic lateral sclerosis.
Brain : a journal of neurology 09, 2018 | Pubmed ID: 30007309
Olfactory dysfunction in amyotrophic lateral sclerosis.
Annals of clinical and translational neurology Aug, 2018 | Pubmed ID: 30128322
Current and emerging ALS biomarkers: utility and potential in clinical trials.
Expert review of neurotherapeutics Nov, 2018 | Pubmed ID: 30273061
Perfluorocarbon Labeling of Human Glial-Restricted Progenitors for F Magnetic Resonance Imaging.
Stem cells translational medicine 04, 2019 | Pubmed ID: 30618148
Role of Human-Induced Pluripotent Stem Cell-Derived Spinal Cord Astrocytes in the Functional Maturation of Motor Neurons in a Multielectrode Array System.
Stem cells translational medicine 12, 2019 | Pubmed ID: 31631575
Focal and dose-dependent neuroprotection in ALS mice following AAV2-neurturin delivery.
Experimental neurology 01, 2020 | Pubmed ID: 31678350
Addressing heterogeneity in amyotrophic lateral sclerosis CLINICAL TRIALS.
Muscle & nerve 08, 2020 | Pubmed ID: 31899540
Persistent Cyfip1 Expression Is Required to Maintain the Adult Subventricular Zone Neurogenic Niche.
The Journal of neuroscience : the official journal of the Society for Neuroscience 03, 2020 | Pubmed ID: 31988061
Expression and Cellular Distribution of P-Glycoprotein and Breast Cancer Resistance Protein in Amyotrophic Lateral Sclerosis Patients.
Journal of neuropathology and experimental neurology 03, 2020 | Pubmed ID: 31999342
Amyotrophic lateral sclerosis care and research in the United States during the COVID-19 pandemic: Challenges and opportunities.
Muscle & nerve 08, 2020 | Pubmed ID: 32445195
Phase 1-2 Trial of Antisense Oligonucleotide Tofersen for ALS.
The New England journal of medicine 07, 2020 | Pubmed ID: 32640130
Effect of Ezogabine on Cortical and Spinal Motor Neuron Excitability in Amyotrophic Lateral Sclerosis: A Randomized Clinical Trial.
JAMA neurology Feb, 2021 | Pubmed ID: 33226425
Mini-Review: Induced pluripotent stem cells and the search for new cell-specific ALS therapeutic targets.
Neuroscience letters 06, 2021 | Pubmed ID: 33892003
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