Olivier Meilhac

[Physiopathology of aortic aneurysm].

Oxidized fatty acids promote atherosclerosis only in the presence of dietary cholesterol in low-density lipoprotein receptor knockout mice.

Pharmacological potentiation of natriuretic peptide limits polymorphonuclear neutrophil-vascular cell interactions.

Pericellular plasmin induces smooth muscle cell anoikis.

Proteomic analysis of human vessels: application to atherosclerotic plaques.

Atorvastatin limits the pro-inflammatory response of rat aortic smooth muscle cells to thrombin.

Protease nexin-1 inhibits plasminogen activation-induced apoptosis of adherent cells.

Role of leukocyte elastase in preventing cellular re-colonization of the mural thrombus.

Identification by a differential proteomic approach of heat shock protein 27 as a potential marker of atherosclerosis.

A paradoxical pro-apoptotic effect of thrombin on smooth muscle cells.

Optimization of in vitro vascular cell transfection with non-viral vectors for in vivo applications.

[The fate of homeless cells].

Mesothelial cell transplantation in the infarct scar induces neovascularization and improves heart function.

Quest for novel cardiovascular biomarkers by proteomic analysis.

Lymphoid neogenesis in chronic rejection: evidence for a local humoral alloimmune response.

Renewal of mural thrombus releases plasma markers and is involved in aortic abdominal aneurysm evolution.

Dual effect of apolipoprotein(a) on plasmin(ogen)-induced apoptosis through modulation of cell detachment of adherent cells.

Biological significance of decreased HSP27 in human atherosclerosis.

Topology of protease activities reflects atherothrombotic plaque complexity.

Biology of atherosclerotic plaques: what we are learning from proteomic analysis.

Low plasma levels of HSP70 in patients with carotid atherosclerosis are associated with increased levels of proteolytic markers of neutrophil activation.

Cardiovascular biomarker discovery by SELDI-TOF mass spectrometry.

Identification of soluble tumor necrosis factor-like weak inducer of apoptosis (sTWEAK) as a possible biomarker of subclinical atherosclerosis.

Topological determinants and consequences of adventitial responses to arterial wall injury.

Proteomics in atherothrombosis: a future perspective.

TWEAK and Fn14. New players in the pathogenesis of atherosclerosis.

Involvement of intraplaque hemorrhage in atherothrombosis evolution via neutrophil protease enrichment.

Plasma concentration of heat shock protein 27 and risk of cardiovascular disease: a prospective, nested case-control study.

Proteomic analysis permits the identification of new biomarkers of arterial wall remodeling in hypertension.

Macrophages and platelets are the major source of protease nexin-1 in human atherosclerotic plaque.

Tissue diffusion and retention of metalloproteinases in ascending aortic aneurysms and dissections.

Mediators of neutrophil recruitment in human abdominal aortic aneurysms.

HDL antielastase activity prevents smooth muscle cell anoikis, a potential new antiatherogenic property.

Immaturity of microvessels in haemorrhagic plaques is associated with proteolytic degradation of angiogenic factors.

Hemorphin 7 reflects hemoglobin proteolysis in abdominal aortic aneurysm.

Culture of human cells and synthesis of extracellular matrix on materials compatible with direct analysis by mass spectrometry.

Peripheral artery disease is associated with a high CD163/TWEAK plasma ratio.

Mesothelial cells vs. skeletal myoblasts for myocardial infarction.

Proteomic and metabolomic profiles in atherothrombotic vascular disease.

Protective effect of high-density lipoprotein-based therapy in a model of embolic stroke.

Implication of adenylyl cyclase 8 in pathological smooth muscle cell migration occurring in rat and human vascular remodelling.

Abnormal presence of the matrix extracellular phosphoglycoprotein-derived acidic serine- and aspartate-rich motif peptide in human hypophosphatemic dentin.

Proteins associated with the size and expansion rate of the abdominal aortic aneurysm wall as identified by proteomic analysis.

Metabolites secreted by human atherothrombotic aneurysms revealed through a metabolomic approach.

Fibrinolytic activity is associated with presence of cystic medial degeneration in aneurysms of the ascending aorta.

Solid-phase hexapeptide ligand libraries open up new perspectives in the discovery of biomarkers in human plasma.

Identification of peroxiredoxin-1 as a novel biomarker of abdominal aortic aneurysm.

Diagnostic and therapeutic strategies for small abdominal aortic aneurysms.

Transcranial duplex sonography for monitoring circle of Willis artery occlusion in a rat embolic stroke model.

Porphyromonas gingivalis participates in pathogenesis of human abdominal aortic aneurysm by neutrophil activation. Proof of concept in rats.

In vitro and in vivo evidence for the role of elastase shedding of CD163 in human atherothrombosis.

Heat-shock proteins in cardiovascular disease.

Early atheroma-derived agonists of peroxisome proliferator-activated receptor-γ trigger intramedial angiogenesis in a smooth muscle cell-dependent manner.

Proteomic analysis of polymorphonuclear neutrophils identifies catalase as a novel biomarker of abdominal aortic aneurysm: potential implication of oxidative stress in abdominal aortic aneurysm progression.

Increased secretion of Gas6 by smooth muscle cells in human atherosclerotic carotid plaques.

Therapeutic potential of fucoidan in myocardial ischemia.

Increased plasma levels of NGAL, a marker of neutrophil activation, in patients with abdominal aortic aneurysm.

Identification and characterization of new gain-of-function mutations in the PCSK9 gene responsible for autosomal dominant hypercholesterolemia.

Salivary proteome modifications associated with periodontitis in obese patients.

Erythrocytes, leukocytes and platelets as a source of oxidative stress in chronic vascular diseases: detoxifying mechanisms and potential therapeutic options.

From intraplaque haemorrhages to plaque vulnerability: biological consequences of intraplaque haemorrhages.

Role of vegetation-associated protease activity in valve destruction in human infective endocarditis.

Fucoidan interferes with Porphyromonas gingivalis-induced aneurysm enlargement by decreasing neutrophil activation.

High-density lipoproteins limit neutrophil-induced damage to the blood-brain barrier in vitro.

High-density lipoprotein-based therapy reduces the hemorrhagic complications associated with tissue plasminogen activator treatment in experimental stroke.

Predominant role of host proteases in myocardial damage associated with infectious endocarditis induced by Enterococcus faecalis in a rat model.

Orosomucoid, a new biomarker in the association between obesity and periodontitis.

Identification of novel biomarkers of abdominal aortic aneurysms by 2D-DIGE and MALDI-MS from AAA-thrombus-conditioned media.

Proteomic Analysis of Intraluminal Thrombus Highlights Complement Activation in Human Abdominal Aortic Aneurysms.

The promises of PCSK9 inhibition.

Impaired high-density lipoprotein anti-oxidant capacity in human abdominal aortic aneurysm.

Supported protein G on gold electrode: characterization and immunosensor application.

Blocking the EP3 receptor for PGE2 with DG-041 decreases thrombosis without impairing haemostatic competence.

Local carotid atherosclerotic plaque proteins for the identification of circulating biomarkers in coronary patients.

Circulating osteoglycin and NGAL/MMP9 complex concentrations predict 1-year major adverse cardiovascular events after coronary angiography.

High-density lipoproteins potentiate α1-antitrypsin therapy in elastase-induced pulmonary emphysema.

Low levels of low-density lipoprotein-C associated with proprotein convertase subtilisin kexin 9 inhibition do not increase the risk of hemorrhagic transformation.

Periodontal bacteria in human carotid atherothrombosis as a potential trigger for neutrophil activation.

Elastase inhibitor AZD9668 treatment prevented progression of experimental abdominal aortic aneurysms.

Antibodies to periodontal pathogens are associated with coronary plaque remodeling but not with vulnerability or burden.

High-density lipoproteins in stroke.

ApoA-I/HDL-C levels are inversely associated with abdominal aortic aneurysm progression.

Evaluation of 42 cytokines, chemokines and growth factors for prediction of cardiovascular outcome in patients with coronary artery disease.

Glycation alters ligand binding, enzymatic, and pharmacological properties of human albumin.

Hemoglobin induces monocyte recruitment and CD163-macrophage polarization in abdominal aortic aneurysm.

The stellate vascular smooth muscle cell phenotype is induced by IL-1β via the secretion of PGE2 and subsequent cAMP-dependent protein kinase A activation.

Detection of Apoptotic Cells in a Rabbit Model with Atherosclerosis-Like Lesions Using the Positron Emission Tomography Radiotracer [18F]ML-10.

High-density lipoprotein therapy inhibits Porphyromonas gingivalis-induced abdominal aortic aneurysm progression.

Impaired constitutive and regenerative neurogenesis in adult hyperglycemic zebrafish.

Intraplaque hemorrhage, a potential consequence of periodontal bacteria gathering in human carotid atherothrombosis.

Dysfunctional HDL in acute stroke.

Diabetes-induced hepatic oxidative stress: a new pathogenic role for glycated albumin.

Quantitative HDL Proteomics Identifies Peroxiredoxin-6 as a Biomarker of Human Abdominal Aortic Aneurysm.

Porphyromonas gingivalis lipopolysaccharide induces pro-inflammatory adipokine secretion and oxidative stress by regulating Toll-like receptor-mediated signaling pathways and redox enzymes in adipocytes.

Anti-inflammatory and antioxidant effects of polyphenols extracted from Antirhea borbonica medicinal plant on adipocytes exposed to Porphyromonas gingivalis and Escherichia coli lipopolysaccharides.

Ultrasound-assisted extraction and structural characterization by NMR of alginates and carrageenans from seaweeds.

Diabetes, adult neurogenesis and brain remodeling: New insights from rodent and zebrafish models.

Glycated human albumin alters mitochondrial respiration in preadipocyte 3T3-L1 cells.

Low HDL levels in sepsis versus trauma patients in intensive care unit.