Institute for Chemistry and Biochemistry
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Activating and deactivating mutations in the receptor interaction site of GDF5 cause symphalangism or brachydactyly type A2.
The Journal of clinical investigation Sep, 2005 | Pubmed ID: 16127465
Monomeric and dimeric GDF-5 show equal type I receptor binding and oligomerization capability and have the same biological activity.
Biological chemistry Apr, 2006 | Pubmed ID: 16606344
Recent advances in BMP receptor signaling.
Cytokine & growth factor reviews Oct-Dec, 2009 | Pubmed ID: 19897402
Quantitative analysis of TGFBR2 mutations in Marfan-syndrome-related disorders suggests a correlation between phenotypic severity and Smad signaling activity.
Journal of cell science Dec, 2010 | Pubmed ID: 21098638
Noggin.
The international journal of biochemistry & cell biology Apr, 2011 | Pubmed ID: 21256973
MicroRNAs differentially expressed in postnatal aortic development downregulate elastin via 3' UTR and coding-sequence binding sites.
PloS one Jan, 2011 | Pubmed ID: 21305018
Comprehensive analysis of TGF-β and BMP receptor interactomes.
European journal of cell biology Apr, 2012 | Pubmed ID: 21715044
A portrait of Transforming Growth Factor β superfamily signalling: Background matters.
The international journal of biochemistry & cell biology Mar, 2012 | Pubmed ID: 22226817
BMPs are mediators in tissue crosstalk of the regenerating musculoskeletal system.
Cell and tissue research Mar, 2012 | Pubmed ID: 22327483
SMAD versus non-SMAD signaling is determined by lateral mobility of bone morphogenetic protein (BMP) receptors.
The Journal of biological chemistry Nov, 2012 | Pubmed ID: 22961979
Structure of the bone morphogenetic protein receptor ALK2 and implications for fibrodysplasia ossificans progressiva.
The Journal of biological chemistry Oct, 2012 | Pubmed ID: 22977237
Constitutively active ALK2 receptor mutants require type II receptor cooperation.
Molecular and cellular biology Jun, 2013 | Pubmed ID: 23572558
Growth and differentiation factor 3 induces expression of genes related to differentiation in a model of cancer stem cells and protects them from retinoic acid-induced apoptosis.
PloS one , 2013 | Pubmed ID: 23950971
BMP10 as a potent inducer of trophoblast differentiation in human embryonic and induced pluripotent stem cells.
Biomaterials Dec, 2013 | Pubmed ID: 24070570
Small molecules dorsomorphin and LDN-193189 inhibit myostatin/GDF8 signaling and promote functional myoblast differentiation.
The Journal of biological chemistry Feb, 2015 | Pubmed ID: 25368322
Bone morphogenetic protein signaling in bone homeostasis.
Bone Nov, 2015 | Pubmed ID: 26051467
VE-cadherin facilitates BMP-induced endothelial cell permeability and signaling.
Journal of cell science Jan, 2016 | Pubmed ID: 26598555
Actions from head to toe: An update on Bone/Body Morphogenetic Proteins in health and disease.
Cytokine & growth factor reviews Feb, 2016 | Pubmed ID: 26803465
Emerging regulators of BMP bioavailability.
Bone Dec, 2016 | Pubmed ID: 26825814
YAP-Mediated Mechanotransduction in Skeletal Muscle.
Frontiers in physiology , 2016 | Pubmed ID: 26909043
Dynamin-dependent endocytosis of Bone Morphogenetic Protein2 (BMP2) and its receptors is dispensable for the initiation of Smad signaling.
The international journal of biochemistry & cell biology 07, 2016 | Pubmed ID: 27113717
The Role of Titanium Surface Nanostructuring on Preosteoblast Morphology, Adhesion, and Migration.
Advanced healthcare materials Aug, 2017 | Pubmed ID: 28371540
Role of bone morphogenetic proteins in sprouting angiogenesis: differential BMP receptor-dependent signaling pathways balance stalk tip cell competence.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 11, 2017 | Pubmed ID: 28733457
IRS4, a novel modulator of BMP/Smad and Akt signalling during early muscle differentiation.
Scientific reports 08, 2017 | Pubmed ID: 28821740
Correction for Bagarova et al., "Constitutively Active ALK2 Receptor Mutants Require Type II Receptor Cooperation".
Molecular and cellular biology 10, 2017 | Pubmed ID: 28899999
Cell-specific responses to the cytokine TGFβ are determined by variability in protein levels.
Molecular systems biology 01, 2018 | Pubmed ID: 29371237
Impaired proteoglycan glycosylation, elevated TGF-β signaling, and abnormal osteoblast differentiation as the basis for bone fragility in a mouse model for gerodermia osteodysplastica.
PLoS genetics 03, 2018 | Pubmed ID: 29561836
Cofilin-1 phosphorylation catalyzed by ERK1/2 alters cardiac actin dynamics in dilated cardiomyopathy caused by lamin A/C gene mutation.
Human molecular genetics 09, 2018 | Pubmed ID: 29878125
Load-induced osteogenic differentiation of mesenchymal stromal cells is caused by mechano-regulated autocrine signaling.
Journal of tissue engineering and regenerative medicine 11, 2019 | Pubmed ID: 31359634
Is NO the Answer? The Nitric Oxide Pathway Can Support Bone Morphogenetic Protein 2 Mediated Signaling.
Cells 10, 2019 | Pubmed ID: 31635347
Lessons from LIMK1 enzymology and their impact on inhibitor design.
The Biochemical journal 11, 2019 | Pubmed ID: 31652302
Sex-specific metabolic and functional differences in human umbilical vein endothelial cells from twin pairs.
Atherosclerosis 12, 2019 | Pubmed ID: 31706078
AMOT130 drives BMP-SMAD signaling at the apical membrane in polarized cells.
Molecular biology of the cell 01, 2020 | Pubmed ID: 31800378
BMPR2 acts as a gatekeeper to protect endothelial cells from increased TGFβ responses and altered cell mechanics.
PLoS biology 12, 2019 | Pubmed ID: 31826007
Biomechanical stress provides a second hit in the establishment of BMP/TGFβ-related vascular disorders.
Cell stress Jan, 2020 | Pubmed ID: 32043077
BMP signalling in a mechanical context - Implications for bone biology.
Bone 08, 2020 | Pubmed ID: 32422297
Enhanced Biological Activity of BMP-2 Bound to Surface-Grafted Heparan Sulfate.
Advanced biosystems Apr, 2017 | Pubmed ID: 32646162
Antagonistic Activities of Vegfr3/Flt4 and Notch1b Fine-tune Mechanosensitive Signaling during Zebrafish Cardiac Valvulogenesis.
Cell reports 07, 2020 | Pubmed ID: 32668254
ActivinA Induced SMAD1/5 Signaling in an iPSC Derived EC Model of Fibrodysplasia Ossificans Progressiva (FOP) Can Be Rescued by the Drug Candidate Saracatinib.
Stem cell reviews and reports Jun, 2021 | Pubmed ID: 33410098
Optimized expression and purification of a soluble BMP2 variant based on in-silico design.
Protein expression and purification Oct, 2021 | Pubmed ID: 34044133
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