Department of Biochemistry and Molecular Biology
Philip Jordan is an Associate Professor in the Biochemistry and Molecular Biology Department, Johns Hopkins University Bloomberg School of Public Health in Baltimore, Maryland. He received his undergraduate with honors degree from Flinders University of South Australia, and a Ph.D. from the University of Edinburgh, UK.
During Dr. Jordan’s training he developed a keen focus on research that encompasses maintenance of genome integrity and cell cycle progression. As a post-doctoral fellow (2007 to 2010) in Eva Hoffman’s lab at the Genome Damage and Stability Center, University of Sussex, UK, he studied the roles of structural maintenance of chromosome complexes (SMC) and cell cycle kinases (Aurora and Polo-like kinases) using budding yeast as a model organism. He then moved to Mary Ann Handel’s lab at the Jackson Laboratory, Maine, USA, as a Fulbright Distinguished Scholar. Here he learned to use mouse as a model organism and continued his research on SMC complexes and cell cycle kinases.
Dr. Jordan received a K99 Pathway to Independence Award from the NIH, and in 2013 he was recruited as faculty at Johns Hopkins University. His research program encompasses using budding yeast, mice, as well as mouse and human stem cells to discover the functions of SMC complexes and cell cycle kinases that ensure genome stability.
The SMC5/6 complex is involved in crucial processes during human spermatogenesis.
Biology of reproduction Jul, 2014 | Pubmed ID: 24855106
Meiosis-specific cohesin component, Stag3 is essential for maintaining centromere chromatid cohesion, and required for DNA repair and synapsis between homologous chromosomes.
PLoS genetics Jul, 2014 | Pubmed ID: 24992337
Resolving complex chromosome structures during meiosis: versatile deployment of Smc5/6.
Chromosoma Mar, 2016 | Pubmed ID: 25947290
Conditional mutation of Smc5 in mouse embryonic stem cells perturbs condensin localization and mitotic progression.
Journal of cell science Apr, 2016 | Pubmed ID: 26919979
Genetic Interactions Between the Meiosis-Specific Cohesin Components, STAG3, REC8, and RAD21L.
G3 (Bethesda, Md.) 06, 2016 | Pubmed ID: 27172213
Dearth and Delayed Maturation of Testicular Germ Cells in Fanconi Anemia E Mutant Male Mice.
PloS one , 2016 | Pubmed ID: 27486799
Sororin is enriched at the central region of synapsed meiotic chromosomes.
Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology Jun, 2017 | Pubmed ID: 28050734
SMC5/6 is required for the formation of segregation-competent bivalent chromosomes during meiosis I in mouse oocytes.
Development (Cambridge, England) 05, 2017 | Pubmed ID: 28302748
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