Reta Lila Weston Institute of Neurological Studies
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The expression of DJ-1 (PARK7) in normal human CNS and idiopathic Parkinson's disease.
Brain : a journal of neurology Feb, 2004 | Pubmed ID: 14662519
Synphilin-1 and parkin show overlapping expression patterns in human brain and form aggresomes in response to proteasomal inhibition.
Neurobiology of disease Nov, 2005 | Pubmed ID: 15894486
Development, characterisation and epitope mapping of novel monoclonal antibodies for DJ-1 (PARK7) protein.
Neuroscience letters Aug, 2005 | Pubmed ID: 15955416
Kinase activity is required for the toxic effects of mutant LRRK2/dardarin.
Neurobiology of disease Aug, 2006 | Pubmed ID: 16750377
DJ-1 (PARK7) is associated with 3R and 4R tau neuronal and glial inclusions in neurodegenerative disorders.
Neurobiology of disease Oct, 2007 | Pubmed ID: 17719794
Post-transcriptional regulation of mRNA associated with DJ-1 in sporadic Parkinson disease.
Neuroscience letters Mar, 2009 | Pubmed ID: 19146923
TDP-43 in ubiquitinated inclusions in the inferior olives in frontotemporal lobar degeneration and in other neurodegenerative diseases: a degenerative process distinct from normal ageing.
Acta neuropathologica Sep, 2009 | Pubmed ID: 19330339
Differential DJ-1 gene expression in Parkinson's disease.
Neurobiology of disease Nov, 2009 | Pubmed ID: 19716892
Pathogenesis of Parkinson's disease: emerging role of molecular chaperones.
Trends in molecular medicine Jan, 2010 | Pubmed ID: 20036196
Brain stem pathology in Parkinson's disease: an evaluation of the Braak staging model.
Movement disorders : official journal of the Movement Disorder Society Nov, 2010 | Pubmed ID: 20818670
A comparative clinical, pathological, biochemical and genetic study of fused in sarcoma proteinopathies.
Brain : a journal of neurology Sep, 2011 | Pubmed ID: 21752791
Globular glial tauopathies (GGT) presenting with motor neuron disease or frontotemporal dementia: an emerging group of 4-repeat tauopathies.
Acta neuropathologica Oct, 2011 | Pubmed ID: 21773886
Pathogenic LRRK2 mutations do not alter gene expression in cell model systems or human brain tissue.
PloS one , 2011 | Pubmed ID: 21799870
Transportin1: a marker of FTLD-FUS.
Acta neuropathologica Nov, 2011 | Pubmed ID: 21847626
α-Synuclein fate is determined by USP9X-regulated monoubiquitination.
Proceedings of the National Academy of Sciences of the United States of America Nov, 2011 | Pubmed ID: 22065755
Phosphorylation of 4E-BP1 in the mammalian brain is not altered by LRRK2 expression or pathogenic mutations.
PloS one , 2012 | Pubmed ID: 23082216
AF-6 is a positive modulator of the PINK1/parkin pathway and is deficient in Parkinson's disease.
Human molecular genetics May, 2013 | Pubmed ID: 23393160
TDP-43 pathology in a patient carrying G2019S LRRK2 mutation and a novel p.Q124E MAPT.
Neurobiology of aging Dec, 2013 | Pubmed ID: 23664753
Divergent α-synuclein solubility and aggregation properties in G2019S LRRK2 Parkinson's disease brains with Lewy Body pathology compared to idiopathic cases.
Neurobiology of disease Oct, 2013 | Pubmed ID: 23747310
Inhibition of LRRK2 kinase activity stimulates macroautophagy.
Biochimica et biophysica acta Dec, 2013 | Pubmed ID: 23916833
Fine-mapping, gene expression and splicing analysis of the disease associated LRRK2 locus.
PloS one , 2013 | Pubmed ID: 23967090
Pathogenic Parkinson's disease mutations across the functional domains of LRRK2 alter the autophagic/lysosomal response to starvation.
Biochemical and biophysical research communications Nov, 2013 | Pubmed ID: 24211199
Functional interaction of Parkinson's disease-associated LRRK2 with members of the dynamin GTPase superfamily.
Human molecular genetics Apr, 2014 | Pubmed ID: 24282027
GTP binding controls complex formation by the human ROCO protein MASL1.
The FEBS journal Jan, 2014 | Pubmed ID: 24286120
Dysregulation of glucose metabolism is an early event in sporadic Parkinson's disease.
Neurobiology of aging May, 2014 | Pubmed ID: 24300239
Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration.
Human molecular genetics Sep, 2014 | Pubmed ID: 24740878
A crucial role for DOK1 in PDGF-BB-stimulated glioma cell invasion through p130Cas and Rap1 signalling.
Journal of cell science Jun, 2014 | Pubmed ID: 24762811
A Parkinson's disease gene regulatory network identifies the signaling protein RGS2 as a modulator of LRRK2 activity and neuronal toxicity.
Human molecular genetics Sep, 2014 | Pubmed ID: 24794857
Arsenite stress down-regulates phosphorylation and 14-3-3 binding of leucine-rich repeat kinase 2 (LRRK2), promoting self-association and cellular redistribution.
The Journal of biological chemistry Aug, 2014 | Pubmed ID: 24942733
Neuropathological features of genetically confirmed DYT1 dystonia: investigating disease-specific inclusions.
Acta neuropathologica communications , 2014 | Pubmed ID: 25403864
Cellular processes associated with LRRK2 function and dysfunction.
The FEBS journal Aug, 2015 | Pubmed ID: 25899482
LRRK2 Facilitates tau Phosphorylation through Strong Interaction with tau and cdk5.
Biochemistry Aug, 2015 | Pubmed ID: 26268594
Leucine-rich repeat kinase 2 interacts with p21-activated kinase 6 to control neurite complexity in mammalian brain.
Journal of neurochemistry Sep, 2015 | Pubmed ID: 26375402
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