Scott G. Kitchen

Activation of CD8 T cells induces expression of CD4, which functions as a chemotactic receptor.

The CCR5 and CXCR4 coreceptors--central to understanding the transmission and pathogenesis of human immunodeficiency virus type 1 infection.

CD4 on CD8(+) T cells directly enhances effector function and is a target for HIV infection.

The CD4 molecule on CD8+ T lymphocytes directly enhances the immune response to viral and cellular antigens.

Rapid size dependent deletion of foreign gene sequences inserted into attenuated HIV-1 upon infection in vivo: implications for vaccine development.

Serum levels of the homeostatic B cell chemokine, CXCL13, are elevated during HIV infection.

T lineage differentiation from human embryonic stem cells.

Enfuvirtide antiretroviral therapy in HIV-1 infection.

Generation of T lineage cells from human embryonic stem cells in a feeder free system.

Engineering antigen-specific T cells from genetically modified human hematopoietic stem cells in immunodeficient mice.

Stem cell-based approaches to treating HIV infection.

Stem cell-based anti-HIV gene therapy.

In Vivo validation of a bioinformatics based tool to identify reduced replication capacity in HIV-1.

Pre-clinical evaluation of a 213Bi-labeled 2556 antibody to HIV-1 gp41 glycoprotein in HIV-1 mouse models as a reagent for HIV eradication.

In vivo suppression of HIV by antigen specific T cells derived from engineered hematopoietic stem cells.