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The Laboratory of Cancer Signaling,
Division of Cellular and Molecular Research,
The Laboratory of Cancer Signaling, Division of Cellular and Molecular Research
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The dimer-dependent catalytic activity of RAF family kinases is revealed through characterizing their oncogenic mutants.
Oncogene 10, 2018 | Pubmed ID: 29930381
The AMPK inhibitor overcomes the paradoxical effect of RAF inhibitors through blocking phospho-Ser-621 in the C terminus of CRAF.
The Journal of biological chemistry 09, 2018 | Pubmed ID: 30030377
Activating mutations in MEK1 enhance homodimerization and promote tumorigenesis.
Science signaling Oct, 2018 | Pubmed ID: 30377225
National Cancer Centre Singapore
Jiajun Yap1,
Jimin Yuan1,
Zi Heng Tee1,
Xuchao Huang1,
Wan Hwa Ng1,
Jiancheng Hu1,2
1The Laboratory of Cancer Signaling, Division of Cellular and Molecular Research, National Cancer Centre Singapore,
2The Cancer and Stem Cell Program, Duke-NUS Medical School
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