Yasuyoshi Ouchi

VEGF-A and FGF-2 synergistically promote neoangiogenesis through enhancement of endogenous PDGF-B-PDGFRbeta signaling.

Hange-koboku-to, a Kampo medicine, modulates cerebral levels of 5-HT (5-hydroxytryptamine), NA (noradrenaline) and DA (dopamine) in mice.

[Malignant lymphoma manifested by fever of unexplained origin and pure red cell aplasia in an elderly patient].

Estrogen-responsive finger protein as a new potential biomarker for breast cancer.

Polymorphisms in four genes related to triglyceride and HDL-cholesterol levels in the general Japanese population in 2000.

Identification of novel steroid target genes through the combination of bioinformatics and functional analysis of hormone response elements.

Tako-tsubo left ventricular dysfunction caused by a fall.

[Sex difference of senescence and diseases in the elderly the growing importance of gender-specific geriatric medicine].

Diethylstilbestrol increases the density of prolactin cells in male mouse pituitary by inducing proliferation of prolactin cells and transdifferentiation of gonadotropic cells.

Statins protect human aortic smooth muscle cells from inorganic phosphate-induced calcification by restoring Gas6-Axl survival pathway.

[Atherosclerosis].

Pleiotropic actions of vitamin K: protector of bone health and beyond?

Prevalence of metabolic syndrome in the general Japanese population in 2000.

Reference values for 6-min walk distance in Asian adults may not be different from that of Caucasian adults.

A functional single nucleotide polymorphism in the vitamin-K-dependent gamma-glutamyl carboxylase gene (Arg325Gln) is associated with bone mineral density in elderly Japanese women.

[An elderly case with nontuberculous mycobacteria acompanied by unilateral massive pleural effusion following the video-assisted thoracic surgery (VATS) for lung cancer].

Signaling pathway of nitric oxide production induced by ginsenoside Rb1 in human aortic endothelial cells: a possible involvement of androgen receptor.

Gas6/Axl-PI3K/Akt pathway plays a central role in the effect of statins on inorganic phosphate-induced calcification of vascular smooth muscle cells.

Q89R polymorphism in the LDL receptor-related protein 5 gene is associated with spinal osteoarthritis in postmenopausal Japanese women.

Beta-defensin overexpression induces progressive muscle degeneration in mice.

Increased expression of estrogen-related receptor alpha (ERRalpha) is a negative prognostic predictor in human prostate cancer.

Improvement of cancer-targeting therapy, using nanocarriers for intractable solid tumors by inhibition of TGF-beta signaling.

Adrenomedullin insufficiency increases allergen-induced airway hyperresponsiveness in mice.

Tako-tsubo-like left ventricular dysfunction in a patient with chronic total occlusion of the left anterior descending artery.

Cytochrome P450 2B6 is a growth-inhibitory and prognostic factor for prostate cancer.

Long-term oxygen administration reduces plasma adrenomedullin levels in patients with obstructive sleep apnea syndrome.

[Reproducible efficacy of tricyclic antidepressant on chronic pain in an elderly patient with osteoporosis].

Association of a single nucleotide polymorphism in the WISP1 gene with spinal osteoarthritis in postmenopausal Japanese women.

[Risk factors associated with the duration of hospitalization in emergency admitted patients with aspiration pneumonia].

Polymorphisms of apolipoprotein e and methylenetetrahydrofolate reductase in the Japanese population.

Primary role of functional ischemia, quantitative evidence for the two-hit mechanism, and phosphodiesterase-5 inhibitor therapy in mouse muscular dystrophy.

[Evaluation of megatrials with antihyperlipidemic agents in Japan].

Sirt1 modulates premature senescence-like phenotype in human endothelial cells.

Effects of age and sex on plasma adrenomedullin levels in patients with obstructive sleep apnea syndrome.

Calcitonin gene-related peptide mediates acid-induced lung injury in mice.

[A 94-year-old woman with nontuberculous mycobacterium who developed small intestinal intussusception associated with a percutaneous endoscopic jejunostomy tube].

Small intestinal intussusceptions caused by percutaneous endoscopic jejunostomy tube placement.

Adiponectin antagonizes stimulatory effect of tumor necrosis factor-alpha on vascular smooth muscle cell calcification: regulation of growth arrest-specific gene 6-mediated survival pathway by adenosine 5'-monophosphate-activated protein kinase.

[An elderly case with group B streptococcal bacteremia, subcutaneous abscess and reactive polyarthritis].

Low testosterone level is an independent determinant of endothelial dysfunction in men.

Effect of nasal continuous positive airway pressure treatment on plasma adrenomedullin levels in patients with obstructive sleep apnea syndrome: roles of nocturnal hypoxia and oxidant stress.

Increase in oxidative stress levels in elderly patients with obstructive sleep apnea syndrome: effects of age and sex.

[Paroxetine-induced hyponatremia in an elderly man due to the syndrome of inappropriate secretion of antidiuretic hormone].

Association of plasma dehydroepiandrosterone-sulfate levels with endothelial function in postmenopausal women with coronary risk factors.

Mechanism of pi-induced vascular calcification.

Association of a single nucleotide polymorphism in the insulin-like growth factor-1 receptor gene with spinal disc degeneration in postmenopausal Japanese women.

Airway hyperresponsiveness in transgenic mice overexpressing platelet activating factor receptor is mediated by an atropine-sensitive pathway.

Effects of long-term and reduced-dose hormone replacement therapy on endothelial function and intima-media thickness in postmenopausal women.

Transient left ventricular apical ballooning without coronary artery stenosis: a form of stunning-like phenomenon?

[Changes of care status before and after the introduction of the long-term care insurance in Japan--results of care status before the long-term care insurance].

Questionnaire survey on the Japanese guidelines for treatment of hypertension in the elderly: 1999 revised version.

[Chronic obstructive pulmonary disease (COPD) in the elderly: analysis from questionnaire about attitudes to the COPD guideline of the Japanese Respiratory Society and actual therapy for COPD used by physicians].

[Estrogen receptor gene polymorphism].

A pivotal role of cytosolic phospholipase A(2) in bleomycin-induced pulmonary fibrosis.

Red wine polyphenols inhibit vascular smooth muscle cell migration through two distinct signaling pathways.

Adverse drug reactions in older people with dementia.

Effect of red wine polyphenols on vascular smooth muscle cell function--molecular mechanism of the 'French paradox'.

[Questionnaire on the attitude of the physicians in educating the elderly patients with chronic obstructive pulmonary disease about smoking cessation].

Efp targets 14-3-3 sigma for proteolysis and promotes breast tumour growth.

Inhibitory effects of novel AP-1 decoy oligodeoxynucleotides on vascular smooth muscle cell proliferation in vitro and neointimal formation in vivo.

Augmentation of immune cell activity against tumor cells by Rauwolfia radix.

Mouse genetic evidence that tranilast reduces smooth muscle cell hyperplasia via a p21(WAF1)-dependent pathway.

Identification of multiple novel epididymis-specific beta-defensin isoforms in humans and mice.

Attenuation of antigen-induced airway hyperresponsiveness in CGRP-deficient mice.

Effects of obstructive sleep apnea on circulating ICAM-1, IL-8, and MCP-1.

Molecular mechanisms underlying human beta-defensin-2 gene expression in a human airway cell line (LC2/ad).

Estrogen activates cyclin-dependent kinases 4 and 6 through induction of cyclin D in rat primary osteoblasts.

Nocturnal gastroesophageal reflux: symptom of obstructive sleep apnea syndrome in association with impaired swallowing.

Induction of anti-metallothionein antibody and mercury treatment decreases bone mineral density in mice.

A potent inhibitor of cytosolic phospholipase A2, arachidonyl trifluoromethyl ketone, attenuates LPS-induced lung injury in mice.

Changing spectrum of infective endocarditis: review of 194 episodes over 20 years.

Increased C-reactive protein and increased plasma interleukin-6 may synergistically affect the progression of coronary atherosclerosis in obstructive sleep apnea syndrome.

Preventing angiographic progression of coronary atherosclerosis with pravastatin.

Guidelines for treatment of hypertension in the elderly--2002 revised version.

Clinical efficacy and toxicity of gefitinib in patients with lung cancer.

EBAG9/RCAS1 expression and its prognostic significance in prostatic cancer.

Gastroesophageal reflux common in patients with sleep apnea rather than snorers without sleep apnea.

Effects of oxygen administration on the circulating vascular endothelial growth factor (VEGF) levels in patients with obstructive sleep apnea syndrome.

Nosocomial infections in adult intensive-care units.

Estrogen receptor beta mediates the inhibitory effect of estradiol on vascular smooth muscle cell proliferation.

Clinical insignificance of (1-->3)-beta-D-glucan in early diagnosis of invasive pulmonary aspergillosis in a patient with chronic obstructive pulmonary disease.

Oxygen administration improves the serum level of nitric oxide metabolites in patients with obstructive sleep apnea syndrome.

17 beta-estradiol inhibits cardiac fibroblast growth through both subtypes of estrogen receptor.

Global burden of COPD in Japan and Asia.

Depletion of glutathione S-transferase P1 induces apoptosis in human lung fibroblasts.

Reduced endothelial vasomotor function and enhanced neointimal formation after vascular injury in a rat model of blood pressure lability.

Diffuse aspiration bronchiolitis due to achalasia.

Protein phosphatase 5 is a negative regulator of estrogen receptor-mediated transcription.

A novel diagnostic test for the risk of aspiration pneumonia in the elderly.

[TGF-beta].

[Tumor necrosis factor receptor(TNFR) gene polymorphism].

Increased plasma interleukin-6 is associated with the pathogenesis of obstructive sleep apnea syndrome.

Platelet-activating factor receptor develops airway hyperresponsiveness independently of airway inflammation in a murine asthma model.

14-3-3sigma is down-regulated in human prostate cancer.

Caveolin-1, Id3a and two LIM protein genes are upregulated by estrogen in vascular smooth muscle cells.

Association of a single-nucleotide polymorphism in low-density lipoprotein receptor-related protein 5 gene with bone mineral density.

Inhibitory effect of low-dose estrogen on neointimal formation after balloon injury of rat carotid artery.

Analysis of estrogen receptor alpha signaling complex at the plasma membrane.

[Right or wrong of the hormone replacement therapy involving osteoporosis].

[Necessity and role of geriatric health services].

Amelioration of vascular endothelial dysfunction in obstructive sleep apnea syndrome by nasal continuous positive airway pressure--possible involvement of nitric oxide and asymmetric NG, NG-dimethylarginine.

Obstructive sleep apnea causes systemic inflammation and metabolic syndrome.

Apoptosis of circulating neutrophils and alveolar macrophages in COPD.

[The role of estrogen in the regulation of blood vessel function].

Association of a single nucleotide polymorphism in the lipoxygenase ALOX15 5'-flanking region (-5229G/A) with bone mineral density.

Estrogen receptor-binding fragment-associated antigen 9 is a tumor-promoting and prognostic factor for renal cell carcinoma.

Tyrosine phosphorylation of paxillin affects the metastatic potential of human osteosarcoma.

Serum lipid survey and its recent trend in the general Japanese population in 2000.

[Epidemiology and prevention of elderly hypertension].

Impact of blood pressure variability on cardiovascular events in elderly patients with hypertension.

Raloxifene analogue LY117018 suppresses oxidative stress-induced endothelial cell apoptosis through activation of ERK1/2 signaling pathway.

Antiplatelet cilostazol, an inhibitor of type III phosphodiesterase, improves swallowing function in patients with a history of stroke.

Cilostazol inhibits oxidative stress-induced premature senescence via upregulation of Sirt1 in human endothelial cells.

FOXP1 is an androgen-responsive transcription factor that negatively regulates androgen receptor signaling in prostate cancer cells.

[Treatment and intervention for sustaining functional activities in community-dwelling elderly people].

Nocturia in elderly people with hypertension--no influence of low-dose thiazide added to losartan.

EBAG9 is a tumor-promoting and prognostic factor for bladder cancer.

Comparison of the effects of the kinase inhibitors imatinib, sorafenib, and transforming growth factor-beta receptor inhibitor on extravasation of nanoparticles from neovasculature.

Amyloid precursor protein is a primary androgen target gene that promotes prostate cancer growth.

Airspace enlargement with airway cell apoptosis in klotho mice: a model of aging lung.

Estrogen receptor-binding fragment-associated gene 9 expression and its clinical significance in human testicular cancer.

A selective estrogen receptor modulator inhibits TNF-alpha-induced apoptosis by activating ERK1/2 signaling pathway in vascular endothelial cells.

Bone mass effects of a Smad6 gene polymorphism in Japanese postmenopausal women.

Association of estrogen receptor alpha and histone deacetylase 6 causes rapid deacetylation of tubulin in breast cancer cells.

TRIM44 interacts with and stabilizes terf, a TRIM ubiquitin E3 ligase.

Expression of cytochrome P450 3A4 and its clinical significance in human prostate cancer.

Sirolimus and everolimus induce endothelial cellular senescence via sirtuin 1 down-regulation: therapeutic implication of cilostazol after drug-eluting stent implantation.

Vitamin K2 suppresses proliferation and motility of hepatocellular carcinoma cells by activating steroid and xenobiotic receptor.

Validity and usefulness of aortic arch calcification in chest X-ray.

A1330V variant of the low-density lipoprotein receptor-related protein 5 (LRP5) gene decreases Wnt signaling and affects the total body bone mineral density in Japanese women.

Association of a single nucleotide polymorphism in the constitutive androstane receptor gene with bone mineral density.

Association of plasma sex hormone levels with functional decline in elderly men and women.

Association of HTRA1 promoter polymorphism with spinal disc degeneration in Japanese women.

Low testosterone level as a predictor of cardiovascular events in Japanese men with coronary risk factors.

Aortic arch calcification detectable on chest X-ray is a strong independent predictor of cardiovascular events beyond traditional risk factors.

Androgen receptor-dependent transactivation of growth arrest-specific gene 6 mediates inhibitory effects of testosterone on vascular calcification.

Age-related changes in plasma androgen levels and their association with cardiovascular risk factors in male Japanese office workers.

Differential expression of estrogen-related receptors beta and gamma (ERRbeta and ERRgamma) and their clinical significance in human prostate cancer.

[A case of a primary effusion lymphoma in the elderly].

Glucocorticoid-induced gene tripartite motif-containing 63 (TRIM63) promotes differentiation of osteoblastic cells.

Androgen receptor-dependent activation of endothelial nitric oxide synthase in vascular endothelial cells: role of phosphatidylinositol 3-kinase/akt pathway.

SIRT1/eNOS axis as a potential target against vascular senescence, dysfunction and atherosclerosis.

[A case of limbic encephalitis with small cell lung carcinoma in which the cognitive function improved and redeteriorated during tumor therapy].

Association of low testosterone with metabolic syndrome and its components in middle-aged Japanese men.

Involvement of androgen receptor in nitric oxide production induced by icariin in human umbilical vein endothelial cells.

Effects of dehydroepiandrosterone supplementation on cognitive function and activities of daily living in older women with mild to moderate cognitive impairment.

Identification of non-synonymous polymorphisms in the WDSOF1 gene as novel susceptibility markers for low bone mineral density in Japanese postmenopausal women.

Effects of testosterone in older men with mild-to-moderate cognitive impairment.

Induction of endothelial nitric oxide synthase, SIRT1, and catalase by statins inhibits endothelial senescence through the Akt pathway.

Visceral fat accumulation and metabolic risk factor clustering in older adults.

Pregnane X receptor knockout mice display osteopenia with reduced bone formation and enhanced bone resorption.

Single-nucleotide polymorphism in the hyaluronan and proteoglycan link protein 1 (HAPLN1) gene is associated with spinal osteophyte formation and disc degeneration in Japanese women.

[Molecular mechanism of vascular aging: impact of vascular smooth muscle cell calcification via cellular senescence].

[Can statins slow the process of vascular calcification? Possibilities of lipid-lowering therapy and pleiotropic effect by statin treatment].

Plasma sex hormone levels and mortality in disabled older men and women.

Coronary artery calcification and cerebral small vessel disease. Association of systemic atherosclerosis.

[Past, present and future of geriatric education in Japan].

Oct1 regulates cell growth of LNCaP cells and is a prognostic factor for prostate cancer.

Risk stratification based on metabolic syndrome as well as non- metabolic risk factors in the assessment of carotid atherosclerosis.

[Inflammatory control on lifestyle-related diseases and bone metabolism].

Association of polypharmacy with fall risk among geriatric outpatients.

ARFGAP3, an androgen target gene, promotes prostate cancer cell proliferation and migration.

Sirtuin 1 retards hyperphosphatemia-induced calcification of vascular smooth muscle cells.

Pulmonary features associated with being underweight in older men.

Obstructive sleep apnea exacerbates endothelial dysfunction in people with metabolic syndrome.

Actions of the Japan Geriatric Society in response to the 2011 off the Pacific Coast of Tohoku Earthquake: first report.

PROX1 suppresses vitamin K-induced transcriptional activity of Steroid and Xenobiotic Receptor.

Clinical significance of steroid and xenobiotic receptor and its targeted gene CYP3A4 in human prostate cancer.

Toward the realization of a better aged society: messages from gerontology and geriatrics.

Polypharmacy as a risk for fall occurrence in geriatric outpatients.

Testosterone deficiency accelerates neuronal and vascular aging of SAMP8 mice: protective role of eNOS and SIRT1.

GPR98/Gpr98 gene is involved in the regulation of human and mouse bone mineral density.

Lower physical activity, but not excessive calorie intake, is associated with metabolic syndrome in elderly with type 2 diabetes mellitus: the Japanese Elderly Diabetes Intervention Trial.

Lower physical activity is a strong predictor of cardiovascular events in elderly patients with type 2 diabetes mellitus beyond traditional risk factors: the Japanese Elderly Diabetes Intervention Trial.

TACC2 is an androgen-responsive cell cycle regulator promoting androgen-mediated and castration-resistant growth of prostate cancer.

Relationship between sleep apnea and respiratory infections in bedridden elderly individuals on tube feeding.

Antimicrobial peptide defensin: identification of novel isoforms and the characterization of their physiological roles and their significance in the pathogenesis of diseases.

[Transition of therapeutics in coronary artery disease: past and present].

Association of circulating sclerostin levels with fat mass and metabolic disease--related markers in Japanese postmenopausal women.

[Therapeutic purpose and treatment guideline of osteoporosis].

Factors associated with prolonged hospital stay in a geriatric ward of a university hospital in Japan.

Src kinase-mediates androgen receptor-dependent non-genomic activation of signaling cascade leading to endothelial nitric oxide synthase.

The high frequency of periodic limb movements in patients with Lewy body dementia.

14-3-3ζ, a novel androgen-responsive gene, is upregulated in prostate cancer and promotes prostate cancer cell proliferation and survival.

Gastrointestinal hemorrhage and antithrombotic drug use in geriatric patients.

High risk of adverse drug reactions in elderly patients taking six or more drugs: analysis of inpatient database.

Ginsenoside Rb1 Prevents MPP(+)-Induced Apoptosis in PC12 Cells by Stimulating Estrogen Receptors with Consequent Activation of ERK1/2, Akt and Inhibition of SAPK/JNK, p38 MAPK.

[Approaches to sarcopenia].

Thrombomodulin, a novel molecule regulating inorganic phosphate-induced vascular smooth muscle cell calcification.

Acute exogenous lipoid pneumonia caused by accidental kerosene ingestion in an elderly patient with dementia: a case report.

Marked improvement of elderly postprandial hypotension by dipeptidyl peptidase IV inhibitor.

Intravascular large B-cell lymphoma with symptoms resembling progressive dementia: a clinical case report.

Priorities of health care outcomes for the elderly.

Involvement of ASK1-p38 pathway in the pathogenesis of diabetes triggered by pancreatic ß cell exhaustion.

C-reactive protein, bone strength, and nine-year fracture risk: data from the Study of Women's Health Across the Nation (SWAN).

[A case of collagenous colitis with watery diarrhea due to lansoprazole use in an elderly woman].

RNA sequencing of MCF-7 breast cancer cells identifies novel estrogen-responsive genes with functional estrogen receptor-binding sites in the vicinity of their transcription start sites.

Vitamin K: novel molecular mechanisms of action and its roles in osteoporosis.

Androgen-responsive long noncoding RNA CTBP1-AS promotes prostate cancer.

Clinical significance of amyloid precursor protein in patients with testicular germ cell tumor.

trans-Resveratrol in Gnetum gnemon protects against oxidative-stress-induced endothelial senescence.

Association of decreased sympathetic nervous activity with mortality of older adults in long-term care.

Respiratory dysrhythmia in dementia with Lewy bodies: a cross-sectional study.

Polymorphism of SLC25A32, the folate transporter gene, is associated with plasma folate levels and bone fractures in Japanese postmenopausal women.

Development of a simple screening test for sarcopenia in older adults.

Liver-specific γ-glutamyl carboxylase-deficient mice display bleeding diathesis and short life span.

Increased risk for cardiovascular outcomes and effect of cholesterol-lowering pravastatin therapy in patients with diabetes mellitus in the pravastatin anti-atherosclerosis trial in the elderly (PATE).

Influences of age, sex, and LDL-C change on cardiovascular risk reduction with pravastatin treatment in elderly Japanese patients: A post hoc analysis of data from the Pravastatin Anti-atherosclerosis Trial in the Elderly (PATE).

Systemic identification of estrogen-regulated genes in breast cancer cells through cap analysis of gene expression mapping.

Pravastatin and olmesartan synergistically ameliorate renal failure-induced vascular calcification.

Large-scale analysis reveals a functional single-nucleotide polymorphism in the 5'-flanking region of PRDM16 gene associated with lean body mass.

Expression of androgen and estrogen signaling components and stem cell markers to predict cancer progression and cancer-specific survival in patients with metastatic prostate cancer.

Association of hearing loss with behavioral and psychological symptoms in patients with dementia.

Inflammatory stimuli induce inhibitory S-nitrosylation of the deacetylase SIRT1 to increase acetylation and activation of p53 and p65.

Metabolic syndrome, sarcopenia and role of sex and age: cross-sectional analysis of Kashiwa cohort study.

Removal of the CPAP Therapy Device During Sleep and Its Association With Body Position Changes and Oxygen Desaturations.

SLC25A24 as a Novel Susceptibility Gene for Low Fat Mass in Humans and Mice.

Osteoblast-Specific γ-Glutamyl Carboxylase-Deficient Mice Display Enhanced Bone Formation with Aberrant Mineralization.

Development of conversion formulae between 4-m, 5-m and 6-m gait speed.

Japan as the front-runner of super-aged societies: Perspectives from medicine and medical care in Japan.

Pregnane x receptor knockout mice display aging-dependent wearing of articular cartilage.

[In Process Citation].