Description of the Key Steps of Living Anionic Polymerization: Distillation and Transfer
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Procedure for Loading Doxorubicin into BCMs
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Results: Characterization and In Vitro Evaluation as a Drug Delivery Platform of the Block Copolymer Based of Poly(ethylene glycol) and Poly(phenyl glycidyl ether)
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Conclusion
필기록
The overall goal of this work is to demonstrate the critical steps needed for synthesis of block copolymer materials by ring opening anionic polymerization, and to show the necessary flow of studies for block copolymer micelles formulation of a hy
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The key steps of living anionic polymerization of phenyl glycidyl ether (PheGE) on methoxy-polyethylene glycol (mPEG-b-PPheGE) are described. The resulting block copolymer micelles (BCMs) were loaded with doxorubicin 14% (wt%) and sustained release of drug over 4 days under physiologically relevant conditions was obtained.