Gerd Geisslinger

Tetrahydrobiopterin Attenuates DSS-evoked Colitis in Mice by Rebalancing Redox and Lipid Signalling.

Loss of HIF-1α in macrophages attenuates AhR/ARNT-mediated tumorigenesis in a PAH-driven tumor model.

Modulation of the central nervous effects of levomethadone by genetic polymorphisms potentially affecting its metabolism, distribution, and drug action.

Current evidence for a genetic modulation of the response to analgesics.

Rapid identification of three functionally relevant polymorphisms in the OATP1B1 transporter gene using Pyrosequencing.

Cardiovascular risk with cyclooxygenase inhibitors: general problem with substance specific differences?

Different COX-independent effects of the COX-2 inhibitors etoricoxib and lumiracoxib.

High sensitive determination of sufentanil in human plasma of parturients and neonates following patient-controlled epidural analgesia (PCEA).

Apoptotic cells promote macrophage survival by releasing the antiapoptotic mediator sphingosine-1-phosphate.

Evidence of COX-2 independent induction of apoptosis and cell cycle block in human colon carcinoma cells after S- or R-ibuprofen treatment.

Cyclooxygenase-2 (COX-2)-independent anticarcinogenic effects of selective COX-2 inhibitors.

The glutamate transporter GLAST is involved in spinal nociceptive processing.

Misestimating the role of an active metabolite when modeling the effects after administration of the parent compound only.

Is mPGES-1 a promising target for pain therapy?

Inhibition of prostaglandin E2 synthesis by SC-560 is independent of cyclooxygenase 1 inhibition.

Nimodipine plasma concentration and retinal blood flow in healthy subjects.

The mu-opioid receptor gene polymorphism 118A>G depletes alfentanil-induced analgesia and protects against respiratory depression in homozygous carriers.

Fatal respiratory depression after multiple intravenous morphine injections.

Pyrosequencing-based screening for genetic polymorphisms in cytochrome P450 2B6 of potential clinical relevance.

GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence.

LC-MS/MS-analysis of sphingosine-1-phosphate and related compounds in plasma samples.

The cyclooxygenase 2 genetic variant -765G>C does not modulate the effects of celecoxib on prostaglandin E2 production.

Pharmacological and histopathological characterization of a hyperalgesia model induced by freeze lesion.

Impaired acute and inflammatory nociception in mice lacking the p50 subunit of NF-kappaB.

FTY720 ameliorates Th1-mediated colitis in mice by directly affecting the functional activity of CD4+CD25+ regulatory T cells.

The effects of COX-2 selective and non-selective NSAIDs on the initiation and progression of atherosclerosis in ApoE-/- mice.

Reliable screening for a pain-protective haplotype in the GTP cyclohydrolase 1 gene (GCH1) through the use of 3 or fewer single nucleotide polymorphisms.

PGD2 metabolism in plasma: kinetics and relationship with bioactivity on DP1 and CRTH2 receptors.

FTY720 ameliorates oxazolone colitis in mice by directly affecting T helper type 2 functions.

Association of saquinavir plasma concentrations with side effects but not with antiretroviral outcome in patients infected with protease inhibitor-susceptible human immunodeficiency virus type 1.

Effects of parecoxib and dipyrone on platelet aggregation in patients undergoing meniscectomy: a double-blind, randomized, parallel-group study.

Tumor cell apoptosis polarizes macrophages role of sphingosine-1-phosphate.

The impact of CREB and its phosphorylation at Ser142 on inflammatory nociception.

Current evidence for a modulation of nociception by human genetic polymorphisms.

Rapid screening for potentially relevant polymorphisms in the human fatty acid amide hydrolase gene using Pyrosequencing.

p53 is important for the anti-proliferative effect of ibuprofen in colon carcinoma cells.

Microarray analysis of altered sphingolipid metabolism reveals prognostic significance of sphingosine kinase 1 in breast cancer.

Pyrosequencing of polymorphisms in the COX-2 gene (PTGS2) with reported clinical relevance.

Proteomics in neuropathic pain research.

Cysteine-rich protein 2, a novel downstream effector of cGMP/cGMP-dependent protein kinase I-mediated persistent inflammatory pain.

Microsomal prostaglandin E2 synthase-1 deletion leads to adverse left ventricular remodeling after myocardial infarction.

Reduced hyperalgesia in homozygous carriers of a GTP cyclohydrolase 1 haplotype.

Biphasic regulation of HMG-CoA reductase expression and activity during wound healing and its functional role in the control of keratinocyte angiogenic and proliferative responses.

Consequences of altered eicosanoid patterns for nociceptive processing in mPGES-1-deficient mice.

Genetic polymorphism of the type A human natriuretic peptide receptor (NPR-A) gene contributes to the interindividual variability in the BNP system.

Antinociceptive activity of the S1P-receptor agonist FTY720.

Dimethylcelecoxib inhibits prostaglandin E2 production.

The anti-proliferative potency of celecoxib is not a class effect of coxibs.

The IKK-NF-kappaB pathway: a source for novel molecular drug targets in pain therapy?

Keratinocyte-derived vascular endothelial growth factor biosynthesis represents a pleiotropic side effect of peroxisome proliferator-activated receptor-gamma agonist troglitazone but not rosiglitazone and involves activation of p38 mitogen-activated protein kinase: implications for diabetes-impaired skin repair.

Celecoxib inhibits 5-lipoxygenase.

Genetic deletion of synapsin II reduces neuropathic pain due to reduced glutamate but increased GABA in the spinal cord dorsal horn.

The selective COX-2 inhibitor celecoxib modulates sphingolipid synthesis.

cGMP produced by NO-sensitive guanylyl cyclase essentially contributes to inflammatory and neuropathic pain by using targets different from cGMP-dependent protein kinase I.

Toponomics analysis of functional interactions of the ubiquitin ligase PAM (Protein Associated with Myc) during spinal nociceptive processing.

Sphingosine 1-phosphate modulates spinal nociceptive processing.

Comparison of nociceptive behavior in prostaglandin E, F, D, prostacyclin and thromboxane receptor knockout mice.

Update on the pathobiology of neuropathic pain.

A common human micro-opioid receptor genetic variant diminishes the receptor signaling efficacy in brain regions processing the sensory information of pain.

The S1P(2) receptor expressed in human platelets is linked to the RhoA-Rho kinase pathway and is down regulated in type 2 diabetes.

Multidrug resistance-related protein 2 genotype of the donor affects kidney graft function.

Inhibition of the soluble epoxide hydrolase attenuates monocrotaline-induced pulmonary hypertension in rats.

Prostaglandin D(2) sustains the pyrogenic effect of prostaglandin E(2).

Ceramide synthases and ceramide levels are increased in breast cancer tissue.

Capturing adenylyl cyclases as potential drug targets.

Genetic variants altering dopamine D2 receptor expression or function modulate the risk of opiate addiction and the dosage requirements of methadone substitution.

Can extremely low or high morphine formation from codeine be predicted prior to therapy initiation?

No NO, no pain? The role of nitric oxide and cGMP in spinal pain processing.

Cross-sectional analysis of the influence of currently known pharmacogenetic modulators on opioid therapy in outpatient pain centers.

Genetic modulation of the pharmacological treatment of pain.

Sphingosine kinase 2 deficient tumor xenografts show impaired growth and fail to polarize macrophages towards an anti-inflammatory phenotype.

Cellular membranes function as a storage compartment for celecoxib.

Identification of human cathepsin G as a functional target of boswellic acids from the anti-inflammatory remedy frankincense.

Toponomics analysis of drug-induced changes in arachidonic acid-dependent signaling pathways during spinal nociceptive processing.

Analgesic efficacy of tramadol, pregabalin and ibuprofen in menthol-evoked cold hyperalgesia.

Inhibitor kappaB Kinase beta deficiency in primary nociceptive neurons increases TRP channel sensitivity.

Cross-sectional assessment of the consequences of a GTP cyclohydrolase 1 haplotype for specialized tertiary outpatient pain care.

Highly sensitive determination of HCV protease inhibitors boceprevir (SCH 503034) and telaprevir (VX 950) in human plasma by LC-MS/MS.

Nonacidic inhibitors of human microsomal prostaglandin synthase 1 (mPGES 1) identified by a multistep virtual screening protocol.

Sulindac sulfide suppresses 5-lipoxygenase at clinically relevant concentrations.

An endocannabinoid system is localized to the hypophysial pars tuberalis of Syrian hamsters and responds to photoperiodic changes.

Cleavage of sphingosine kinase 2 by caspase-1 provokes its release from apoptotic cells.

Soluble epoxide hydrolase deficiency attenuates neointima formation in the femoral cuff model of hyperlipidemic mice.

Analysis of NF-kappaB signaling pathways by proteomic approaches.

Ziconotide for treatment of severe chronic pain.

Alterations in the hippocampal endocannabinoid system in diet-induced obese mice.

A critical appraisal of human genotyping for pain therapy.

Higher pain scores, similar opioid doses and side effects associated with antipyretic analgesics in specialised tertiary pain care.

R-flurbiprofen reduces neuropathic pain in rodents by restoring endogenous cannabinoids.

Epigenetics in pain and analgesia: an imminent research field.

Dimethylcelecoxib inhibits mPGES-1 promoter activity by influencing EGR1 and NF-κB.

Inhibition of the soluble epoxide hydrolase promotes albuminuria in mice with progressive renal disease.

Activation of ceramide synthase 6 by celecoxib leads to a selective induction of C16:0-ceramide.

Pharmacogenetics of new analgesics.

Localization of an endocannabinoid system in the hypophysial pars tuberalis and pars distalis of man.

Anti-inflammatory role of microsomal prostaglandin E synthase-1 in a model of neuroinflammation.

The ubiquitin ligase MYCBP2 regulates transient receptor potential vanilloid receptor 1 (TRPV1) internalization through inhibition of p38 MAPK signaling.

Screening for IL28B gene variants identifies predictors of hepatitis C therapy success.

Role of nucleoside transporters SLC28A2/3 and SLC29A1/2 genetics in ribavirin therapy: protection against anemia in patients with chronic hepatitis C.

MicroRNAs as new players in the pain game.

SNO-ing at the nociceptive synapse?

Macrophages programmed by apoptotic cells promote angiogenesis via prostaglandin E2.

Nerve injury evoked loss of latexin expression in spinal cord neurons contributes to the development of neuropathic pain.

CNGA3: a target of spinal nitric oxide/cGMP signaling and modulator of inflammatory pain hypersensitivity.

The protein kinase IKKε is a potential target for the treatment of inflammatory hyperalgesia.

Group V phospholipase A2 in bone marrow-derived myeloid cells and bronchial epithelial cells promotes bacterial clearance after Escherichia coli pneumonia.

Prolonged zymosan-induced inflammatory pain hypersensitivity in mice lacking glycine receptor alpha2.

Inhibitors of specific ceramide synthases.

Soluble epoxide hydrolase limits mechanical hyperalgesia during inflammation.

Dimethylcelecoxib induces an inhibitory complex consisting of HDAC1/NF-κB(p65)RelA leading to transcriptional downregulation of mPGES-1 and EGR1.

Low-dose drug combinations along molecular pathways could maximize therapeutic effectiveness while minimizing collateral adverse effects.

Single and combined IL28B, ITPA and SLC28A3 host genetic markers modulating response to anti-hepatitis C therapy.

Chain length-specific properties of ceramides.

Additive antinociceptive effects of a combination of vitamin C and vitamin E after peripheral nerve injury.

Long chain ceramides and very long chain ceramides have opposite effects on human breast and colon cancer cell growth.

Identification of DNA-protein complexes using an improved, combined western blotting-electrophoretic mobility shift assay (WEMSA) with a fluorescence imaging system.

Sniffing out pharmacology: interactions of drugs with human olfaction.

The pharmacogenetic background of hepatitis C treatment.

Structure-activity relationship of nonacidic quinazolinone inhibitors of human microsomal prostaglandin synthase 1 (mPGES 1).

Site-specific and time-dependent activation of the endocannabinoid system after transection of long-range projections.

Ceramide synthase 6 plays a critical role in the development of experimental autoimmune encephalomyelitis.

5,6-EET is released upon neuronal activity and induces mechanical pain hypersensitivity via TRPA1 on central afferent terminals.

Inhibitor kappa B kinase beta dependent cytokine upregulation in nociceptive neurons contributes to nociceptive hypersensitivity after sciatic nerve injury.

Lack of microsomal prostaglandin E(2) synthase-1 in bone marrow-derived myeloid cells impairs left ventricular function and increases mortality after acute myocardial infarction.

Analysis of sphingolipid and prostaglandin synthesis during zymosan-induced inflammation.

The p21-activated kinase PAK 5 is involved in formalin-induced nociception through regulation of MAP-kinase signaling and formalin-specific receptors.

Inhibition of GTP cyclohydrolase attenuates tumor growth by reducing angiogenesis and M2-like polarization of tumor associated macrophages.

NADPH oxidase-4 maintains neuropathic pain after peripheral nerve injury.

Necessity and risks of arterial blood sampling in healthy volunteer studies.

Pharmacokinetics of non-intravenous formulations of fentanyl.

NOXious signaling in pain processing.

Phenotyping the function of TRPV1-expressing sensory neurons by targeted axonal silencing.

Intrinsic up-regulation of 2-AG favors an area specific neuronal survival in different in vitro models of neuronal damage.

Modulation of central nervous system-specific microRNA-124a alters the inflammatory response in the formalin test in mice.

Cannabinoid-mediated diversity of antinociceptive efficacy of parecoxib in Wistar and Sprague Dawley rats in the chronic constriction injury model of neuropathic pain.

Antioxidant activity of sestrin 2 controls neuropathic pain after peripheral nerve injury.

The equilibrium between long and very long chain ceramides is important for the fate of the cell and can be influenced by co-expression of CerS.

Functional genomics of pain in analgesic drug development and therapy.

Proteomics and NF-κB: an update.

Novel findings in pain processing pathways: implications for miRNAs as future therapeutic targets.

Heterologously expressed formyl peptide receptor 2 (FPR2/ALX) does not respond to lipoxin A₄.

Cysteinyl leukotriene-receptor-1 antagonists interfere with PGE2 synthesis by inhibiting mPGES-1 activity.

Opioids for chronic non-cancer pain.

Non-invasive combined surrogates of remifentanil blood concentrations with relevance to analgesia.

Ceramide metabolism in mouse tissue.

Exogenous delta⁹-tetrahydrocannabinol influences circulating endogenous cannabinoids in humans.

Activation of the AMP-activated protein kinase reduces inflammatory nociception.

Prostacyclin regulates spinal nociceptive processing through cyclic adenosine monophosphate-induced translocation of glutamate receptors.

Common non-epigenetic drugs as epigenetic modulators.

Synthesis and pharmacological characterization of benzenesulfonamides as dual species inhibitors of human and murine mPGES-1.

Electrophilic fatty acid species inhibit 5-lipoxygenase and attenuate sepsis-induced pulmonary inflammation.

TRP-channels as key integrators of lipid pathways in nociceptive neurons.

BKCa channels expressed in sensory neurons modulate inflammatory pain in mice.

Prostacyclin mediates neuropathic pain through interleukin 1β-expressing resident macrophages.

Synthesis of lipid mediators during UVB-induced inflammatory hyperalgesia in rats and mice.

PGE2/EP4 signaling in peripheral immune cells promotes development of experimental autoimmune encephalomyelitis.

Oxidant-induced activation of cGMP-dependent protein kinase Iα mediates neuropathic pain after peripheral nerve injury.

Similar maximum systemic but not local cyclooxygenase-2 inhibition by 50 mg lumiracoxib and 90 mg etoricoxib: a randomized controlled trial in healthy subjects.

Inhibition of macrophage fatty acid β-oxidation exacerbates palmitate-induced inflammatory and endoplasmic reticulum stress responses.

Neutrophils mediate edema formation but not mechanical allodynia during zymosan-induced inflammation.

Telaprevir drug monitoring during antiviral therapy of hepatitis C graft infection after liver transplantation.

LPS inhibits caspase 3-dependent apoptosis in RAW264.7 macrophages induced by the AMPK activator AICAR.

Genome-wide transcriptional profiling of skin and dorsal root ganglia after ultraviolet-B-induced inflammation.

Consequences of a human TRPA1 genetic variant on the perception of nociceptive and olfactory stimuli.

Phosphodiesterase 2A localized in the spinal cord contributes to inflammatory pain processing.

Lipoxin A₄: problems with its determination using reversed phase chromatography-tandem mass spectrometry and confirmation with chiral chromatography.

Lack of effect of a P2Y6 receptor antagonist on neuropathic pain behavior in mice.

Chiral chromatography-tandem mass spectrometry applied to the determination of pro-resolving lipid mediators.

Nox2-dependent signaling between macrophages and sensory neurons contributes to neuropathic pain hypersensitivity.

Regulation of ceramide synthase 6 in a spontaneous experimental autoimmune encephalomyelitis model is sex dependent.

R-flurbiprofen attenuates experimental autoimmune encephalomyelitis in mice.

Mechanism-based treatment for chemotherapy-induced peripheral neuropathic pain.

Role of telaprevir plasma levels for predicting response to antiviral therapy in patients with hepatitis C virus genotype 1 infection.

Ceramide synthases CerS4 and CerS5 are upregulated by 17β-estradiol and GPER1 via AP-1 in human breast cancer cells.

Regulation of circulating endocannabinoids associated with cancer and metastases in mice and humans.

Slack channels expressed in sensory neurons control neuropathic pain in mice.

Pattern of neuropathic pain induced by topical capsaicin application in healthy subjects.

Lack of ceramide synthase 2 suppresses the development of experimental autoimmune encephalomyelitis by impairing the migratory capacity of neutrophils.

Antinociceptive effects of FTY720 during trauma-induced neuropathic pain are mediated by spinal S1P receptors.

Quantitation of endogenous nucleoside triphosphates and nucleosides in human cells by liquid chromatography tandem mass spectrometry.

Exacerbation of experimental autoimmune encephalomyelitis in ceramide synthase 6 knockout mice is associated with enhanced activation/migration of neutrophils.

MPGES-1-derived PGE2 suppresses CD80 expression on tumor-associated phagocytes to inhibit anti-tumor immune responses in breast cancer.

Activated platelets release sphingosine 1-phosphate and induce hypersensitivity to noxious heat stimuli in vivo.

TANK-binding kinase 1 (TBK1) modulates inflammatory hyperalgesia by regulating MAP kinases and NF-κB dependent genes.

AMP-activated protein kinase is activated by non-steroidal anti-inflammatory drugs.

Rhythmic control of endocannabinoids in the rat pineal gland.

Activation of AMPK and its Impact on Exercise Capacity.

The H2S-producing enzyme CSE is dispensable for the processing of inflammatory and neuropathic pain.

AMP-activated protein kinase suppresses arachidonate 15-lipoxygenase expression in interleukin 4-polarized human macrophages.

Lipoxin and resolvin biosynthesis is dependent on 5-lipoxygenase activating protein.

Age-Dependent Changes in the Inflammatory Nociceptive Behavior of Mice.

N-Benzylbenzamides: A Novel Merged Scaffold for Orally Available Dual Soluble Epoxide Hydrolase/Peroxisome Proliferator-Activated Receptor γ Modulators.

In Vivo Availability of Pro-Resolving Lipid Mediators in Oxazolone Induced Dermal Inflammation in the Mouse.

S1P2/G12/13 Signaling Negatively Regulates Macrophage Activation and Indirectly Shapes the Atheroprotective B1-Cell Population.

Small molecules with anti-inflammatory properties in clinical development.

Alpha-methylacyl-CoA racemase deletion has mutually counteracting effects on T-cell responses, associated with unchanged course of EAE.

Drug Repurposing for the Development of Novel Analgesics.

The protein kinase IKKepsilon contributes to tumour growth and tumour pain in a melanoma model.

The impact of endurance exercise on global and AMPK gene-specific DNA methylation.

PAFAH1B1 and the lncRNA NONHSAT073641 maintain an angiogenic phenotype in human endothelial cells.