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Barry J. Margulies

Towson University Herpes Virus Lab,
Department of Biological Sciences,
Molecular Biology,
Biochemistry,
and Bioinformatics Program,
Towson University Herpes Virus Lab, Department of Biological Sciences,
Molecular Biology, Biochemistry, and Bioinformatics Program

Towson University

BIOGRAPHY

Dr. Barry Margulies received B.S. at the Massachusetts Institute of Technology in Applied Biological Sciences, where he did research with Drs. Eyal Ron and Robert Langer in controlled release technology. He earned his Ph.D. at the Johns Hopkins University School of Medicine in the Biochemistry, Cellular, and Molecular Biology Program under the tutelage of Dr. Wade Gibson, where he studied the G protein-coupled receptors encoded by human cytomegalovirus. He did his post-doctoral studies also at the Johns Hopkins University School of Medicine (Division of Comparative Medicine), with Dr. Janice Clements, studying CD4-independent entry of human and simian immunodeficiency viruses. He was a professor at Towson University from 2001-2021, where he established the Towson University Herpes Virus Lab. His research encompassed studies in the molecular biology of human cytomegalovirus and new methods for the long-term prevention of recurrent outbreaks of herpes simplex viruses-1 and -2, varicella zoster virus, and feline herpes virus-1. He is currently working at the NIH in the National Institute of Allergy and Infectious Diseases in the Division of Extramural Affairs.

PUBLICATIONS

The chemokine receptor homologue encoded by US27 of human cytomegalovirus is heavily glycosylated and is present in infected human foreskin fibroblasts and enveloped virus particles.

Virus research Jan, 2007 | Pubmed ID: 16963142

Development of an aciclovir implant for the effective long-term control of herpes simplex virus type-1 infection in Vero cells and in experimentally infected SKH-1 mice.

International journal of antimicrobial agents Nov, 2007 | Pubmed ID: 17851051

Alternative assessment strategy and its impact on student comprehension in an undergraduate microbiology course.

Microbiology education May, 2005 | Pubmed ID: 23653557

Silicone-acyclovir controlled release devices suppress primary herpes simplex virus-2 and varicella zoster virus infections in vitro.

Advances in pharmacological sciences , 2013 | Pubmed ID: 23983683

Controlled release delivery of penciclovir via a silicone (MED-4750) polymer: kinetics of drug delivery and efficacy in preventing primary feline herpesvirus infection in culture.

Virology journal Feb, 2014 | Pubmed ID: 24558980

The human cytomegalovirus chemokine receptor homolog encoded by US27.

Virus genes Aug, 2017 | Pubmed ID: 28447191

Volatile Acid-Solvent Evaporation (VASE): Molecularly Homogeneous Distribution of Acyclovir in a Bioerodable Polymer Matrix for Long-Term Treatment of Herpes Simplex Virus-1 Infections.

Journal of drug delivery , 2018 | Pubmed ID: 30356432

Pilot Study of the Safety and Tolerability of a Subconjunctival Penciclovir Implant in Cats Experimentally Infected with Herpesvirus.

Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics Jan/Feb, 2019 | Pubmed ID: 30562134

Acyclovir, cidofovir, and amenamevir have additive antiviral effects on herpes simplex virus TYPE 1.

Antiviral research 04, 2020 | Pubmed ID: 32114034

MATRIX-BASED CONTROLLED RELEASE DELIVERY OF ACYCLOVIR FROM POLY-(ETHYLENE CO-VINYL ACETATE) RINGS.

Journal of drug delivery science and technology Feb, 2020 | Pubmed ID: 32863890

Current Drugs to Treat Infections with Herpes Simplex Viruses-1 and -2.

Viruses Jun, 2021 | Pubmed ID: 34202050

INSTITUTIONS

Towson University

JOVE ARTICLES

Plaquing of Herpes Simplex Viruses

Lauren A. Sadowski^*,1,

Gregory M. Lesko^*,1,

Chad Suissa^*,1,

Rista Upadhyay^*,1,2,

Prashant J. Desai³,

Barry J. Margulies^1,4

¹Towson University Herpes Virus Lab, Department of Biological Sciences, Towson University,

²Towson University Department of Chemistry, Towson University,

³Department of Oncology, Johns Hopkins University School of Medicine,

⁴Molecular Biology, Biochemistry, and Bioinformatics Program, Towson University

Immunology and Infection

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