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Dongsu Park

Center for Regenerative Medicine,
Massachusetts General Hospital,
Center for Regenerative Medicine, Massachusetts General Hospital

Harvard Stem Cell Institute

BIOGRAPHY

I received my Ph.D. degree in Immunology from Baylor College of Medicine in 2007 and continued postdoctoral training in Stem Cell Biology with Dr. David T. Scadden at the MGH and Harvard Medical School until 2013. My early studies uncovered a novel regulatory mechanism of immune cells and dendritic cell survival mechanism to induce anti-cancer immunity. Later, I extended these researches to discover the in vivo kinetics of bone forming cells and in vivo identity of skeletal stem cells in periosteum (outer bone layer) and bone marrow. We now focus on uncovering skeletal stem cell heterogeneity, their specific regulators and novel therapeutic strategies targeting bone diseases, regeneration and aging.

PUBLICATIONS

An essential role for Akt1 in dendritic cell function and tumor immunotherapy.

Nature biotechnology Dec, 2006 | Pubmed ID: 17143278

The adaptor protein Lad associates with the G protein beta subunit and mediates chemokine-dependent T-cell migration.

Blood Jun, 2007 | Pubmed ID: 17327418

The hematopoietic stem cell niche.

Frontiers in bioscience : a journal and virtual library , 2012 | Pubmed ID: 22201730

Activation of Wnt signaling by chemically induced dimerization of LRP5 disrupts cellular homeostasis.

PloS one , 2012 | Pubmed ID: 22303459

Endogenous bone marrow MSCs are dynamic, fate-restricted participants in bone maintenance and regeneration.

Cell stem cell Mar, 2012 | Pubmed ID: 22385654

Stress hematopoiesis is regulated by the Krüppel-like transcription factor ZBP-89.

Stem cells (Dayton, Ohio) Mar, 2014 | Pubmed ID: 24549639

Democratized image analytics by visual programming through integration of deep models and small-scale machine learning.

Nature communications 10, 2019 | Pubmed ID: 31591416

Lineage Tracing Reveals a Subset of Reserve Muscle Stem Cells Capable of Clonal Expansion under Stress.

Cell stem cell Jun, 2019 | Pubmed ID: 31006621

INSTITUTIONS

Harvard Stem Cell Institute

Baylor College of Medicine

JOVE ARTICLES

Sequential In vivo Imaging of Osteogenic Stem/Progenitor Cells During Fracture Repair

Dongsu Park¹,

Joel A. Spencer²,

Charles P. Lin²,

David T. Scadden¹

¹Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Stem Cell Institute,

²Wellman Center for Photomedicine and Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School

Medicine

Real-Time Imaging of CCL5-Induced Migration of Periosteal Skeletal Stem Cells in Mice

Laura Ortinau^1,2,

Kevin Lei¹,

Youngjae Jeong¹,

Dongsu Park^1,2,3

¹Department of Molecular & Human Genetics, Baylor College of Medicine,

²Center for Skeletal Biology, Baylor College of Medicine,

³Department of Pathology & Immunology, Baylor College of Medicine

Developmental Biology

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Dongsu Park

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Harvard Stem Cell Institute

Sequential In vivo Imaging of Osteogenic Stem/Progenitor Cells During Fracture Repair

Real-Time Imaging of CCL5-Induced Migration of Periosteal Skeletal Stem Cells in Mice

Center for Regenerative Medicine,
Massachusetts General Hospital,
Center for Regenerative Medicine, Massachusetts General Hospital