Sophie Regan

Functional and toxicological consequences of metabolic bioactivation of methapyrilene via thiophene S-oxidation: Induction of cell defence, apoptosis and hepatic necrosis.

High-mobility group box-1 protein and keratin-18, circulating serum proteins informative of acetaminophen-induced necrosis and apoptosis in vivo.

Acyl glucuronides: the good, the bad and the ugly.

Convenient syntheses of benzo-fluorinated dibenz[b,f]azepines: rearrangements of isatins, acridines, and indoles.

The genotoxic potential of methapyrilene using the alkaline Comet assay in vitro and in vivo.

Haloarene derivatives of carbamazepine with reduced bioactivation liabilities: 2-monohalo and 2,8-dihalo derivatives.

The generation, detection, and effects of reactive drug metabolites.

The impact of early postoperative pain on health-related quality of life.

Mass spectrometric characterization of circulating covalent protein adducts derived from a drug acyl glucuronide metabolite: multiple albumin adductions in diclofenac patients.

Timescale analysis of a mathematical model of acetaminophen metabolism and toxicity.