phosphorus-31-magnetic-resonance-spectroscopy-tool-for-measuring-vivo

Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring <em>In Vivo</em> Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle

Skeletal muscle mitochondrial oxidative phosphorylation (OXPHOS) capacity, which is critically important in health and disease, can be measured in vivo ...

The Ohio State University

We have previously shown that serum VEGF-D is elevated at baseline, correlates with kidney angiomyolipoma size at baseline and 12 months, and decreases with sirolimus treatment in adults with tuberous sclerosis complex (TSC). To further investigate the utility of serum VEGF-D for longer term monitoring of TSC kidney disease, we present VEGF-D level results with 24 month follow-up.

Similar trends in serum VEGF-D levels and kidney angiomyolipoma responses with longer duration sirolimus treatment in adults with tuberous sclerosis.

To investigate the associations between ectopic and serum lipid levels and bone marrow fat, as a marker of stem cell differentiation, in young obese men and women, with the hypothesis that ectopic and serum lipid levels would be positively associated with bone marrow fat.

Ectopic and serum lipid levels are positively associated with bone marrow fat in obesity.

To examine the association between inframalleolar peroneal tendon abnormalities and an enlarged peroneal tubercle.

Peroneal tendon abnormalities in subjects with an enlarged peroneal tubercle.

Dual-energy computed tomography (DECT) improves material and tissue characterization compared with single-energy CT; we sought to validate coronary calcium quantification in advancing cardiovascular DECT. In an anthropomorphic phantom, agreement between measurements was excellent, and Bland-Altman analysis demonstrated minimal bias. Compared with the known calcium mass for each phantom, calcium mass by DECT was highly accurate. Noncontrast DECT yields accurate calcium measures and warrants consideration in cardiac protocols for additional tissue characterizations.

Computation of Calcium Score With Dual-Energy Computed Tomography: A Phantom Study.

Losartan, an angiotensin II receptor blocker, can reduce desmoplasia and enhance drug delivery and efficacy through improving interstitial transport and vascular perfusion in pancreatic ductal adenocarcinoma (PDAC) models in mice. The purpose of this study was to determine whether magnetic resonance imaging (MRI) of magnetic iron oxide nanoparticles (MNPs) and micro-positron emission tomography (PET) measurements could respectively detect improvements in tumor vascular parameters and drug uptake in orthotopic PDAC in mice treated with losartan.

Vidhya Kumar

Davis Heart and Lung Research Institute

The Ohio State University

Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle

Vidhya Kumar

.css-o250i3{font-size:18px;font-family:Open Sans,sans-serif;line-height:21.6px;}Davis Heart and Lung Research Institute

The Ohio State University

Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle

Davis Heart and Lung Research Institute