generation-knock-out-primary-expanded-human-nk-cells-using-cas9

Generation of Knock-out Primary and Expanded Human NK Cells Using Cas9 Ribonucleoproteins

CRISPR/Cas9 technology is accelerating genome engineering in many cell types, but so far, gene delivery and stable gene modification have been challenging ...

Nationwide Children's Hospital

We have previously shown that radiotherapy (RT) augments natural killer (NK) functions in pre-clinical models of human and mouse cancers, including sarcomas. Since dogs are an excellent outbred model for immunotherapy studies, we sought to assess RT plus local autologous NK transfer in canine sarcomas.

Jennifer A. Foltz

Center for Childhood Cancer and Blood Disease

Nationwide Children's Hospital

Generation of Knock-out Primary and Expanded Human NK Cells Using Cas9 Ribonucleoproteins

Jennifer A. Foltz

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Nationwide Children's Hospital

Generation of Knock-out Primary and Expanded Human NK Cells Using Cas9 Ribonucleoproteins

Center for Childhood Cancer and Blood Disease