Mihaela Gadjeva
Department of Medicine,
Division of Infectious Diseases,
Brigham and Women's Hospital,
Department of Medicine, Division of Infectious Diseases, Brigham and Women's Hospital
Harvard Medical School
Dr. Gadjeva is an internationally recognized immunologist with research interests in host-bacterial pathogenesis. She has an undergraduate and graduate degrees in Biochemistry from Sofia University, Bulgaria, and Oxford University, UK, and a postdoctoral training at Brigham and Women’s Hospital (BWH), Harvard Medical School. She rose through the ranks of Instructor, Assistant and Associate Professor at BWH/HMS. Currently, Dr. Gadjeva’s laboratory is at BWH/HMS and hosts graduate students and postdoctoral fellows to explore how commensals induce signals at mucosal surfaces to control innate immunity to pathogens. The objective is to leverage this knowledge to discover novel therapeutic approaches to strengthen immunity during bacterial infections. Dr. Gadjeva has published more than 50 peer-reviewed scientific manuscripts of and review articles. She has received continuous peer-reviewed, NIH grant support from for the past 11 years and recently received an HMS Innovation Grant in the Basic and Social Sciences. Dr. Gadjeva’s contributions have been recognized by a First Place ARVO-AFER Merck Innovative Ophthalmology Award. Dr. Gadjeva is serving as a member of NIH and DOD study sections, a reviewer for leading journals in the field, and an adviser to the Biotechnology Graduate degree program at Harvard University.
Label-free electrical sensing of bacteria in eye wash samples: A step towards point-of-care detection of pathogens in patients with infectious keratitis.
Biosensors & bioelectronics May, 2017 | Pubmed ID: 27987408
Myeloid C3 determines induction of humoral responses to peripheral herpes simplex virus infection.
Journal of immunology (Baltimore, Md. : 1950) Nov, 2003 | Pubmed ID: 14607939
A role for NF-kappa B subunits p50 and p65 in the inhibition of lipopolysaccharide-induced shock.
Journal of immunology (Baltimore, Md. : 1950) Nov, 2004 | Pubmed ID: 15494531
Airway epithelial control of Pseudomonas aeruginosa infection in cystic fibrosis.
Trends in molecular medicine Mar, 2008 | Pubmed ID: 18262467
Interaction of human C1q with IgG and IgM: revisited.
Biochemistry Dec, 2008 | Pubmed ID: 19006321
Cystic fibrosis transmembrane conductance regulator and caveolin-1 regulate epithelial cell internalization of Pseudomonas aeruginosa.
American journal of physiology. Cell physiology Aug, 2009 | Pubmed ID: 19386787
Mannan-binding lectin deficiency modulates the humoral immune response dependent on the genetic environment.
Immunology Jun, 2009 | Pubmed ID: 19476514
Analysis of acquisition of Pseudomonas aeruginosa gastrointestinal mucosal colonization and horizontal transmission in a murine model.
The Journal of infectious diseases Jan, 2010 | Pubmed ID: 19938976
Caveolin-1 modifies the immunity to Pseudomonas aeruginosa.
Journal of immunology (Baltimore, Md. : 1950) Jan, 2010 | Pubmed ID: 19949109
Inhibition of macrophage migration inhibitory factor ameliorates ocular Pseudomonas aeruginosa-induced keratitis.
PLoS pathogens Mar, 2010 | Pubmed ID: 20361053
Animal and human antibodies to distinct Staphylococcus aureus antigens mutually neutralize opsonic killing and protection in mice.
The Journal of clinical investigation Sep, 2010 | Pubmed ID: 20739753
CD74 deficiency ameliorates Pseudomonas aeruginosa-induced ocular infection.
Scientific reports , 2011 | Pubmed ID: 22355577
Homotrimeric macrophage migration inhibitory factor (MIF) drives inflammatory responses in the corneal epithelium by promoting caveolin-rich platform assembly in response to infection.
The Journal of biological chemistry Mar, 2013 | Pubmed ID: 23372160
Cochlin produced by follicular dendritic cells promotes antibacterial innate immunity.
Immunity May, 2013 | Pubmed ID: 23684986
The complement system. Overview.
Methods in molecular biology (Clifton, N.J.) , 2014 | Pubmed ID: 24218246
Opsonophagocytic assay.
Methods in molecular biology (Clifton, N.J.) , 2014 | Pubmed ID: 24218277
Cystic fibrosis sputum DNA has NETosis characteristics and neutrophil extracellular trap release is regulated by macrophage migration-inhibitory factor.
Journal of innate immunity , 2014 | Pubmed ID: 24862346
Distinct susceptibilities of corneal Pseudomonas aeruginosa clinical isolates to neutrophil extracellular trap-mediated immunity.
Infection and immunity Oct, 2014 | Pubmed ID: 25047845
Does NETosis Contribute to the Bacterial Pathoadaptation in Cystic Fibrosis?
Frontiers in immunology , 2014 | Pubmed ID: 25157250
Macrophage migration inhibitory factor promotes cyst growth in polycystic kidney disease.
The Journal of clinical investigation Jun, 2015 | Pubmed ID: 25961459
Intestinal Microbiota of Mice Influences Resistance to Staphylococcus aureus Pneumonia.
Infection and immunity Oct, 2015 | Pubmed ID: 26216419
TSP-1 Deficiency Alters Ocular Microbiota: Implications for Sjögren's Syndrome Pathogenesis.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics Sep, 2015 | Pubmed ID: 26352162
Impact of Microbiome on Ocular Health.
The ocular surface 07, 2016 | Pubmed ID: 27189865
Impact of Microbiota on Resistance to Ocular Pseudomonas aeruginosa-Induced Keratitis.
PLoS pathogens Sep, 2016 | Pubmed ID: 27658245
Immune Recognition of the Epidemic Cystic Fibrosis Pathogen Burkholderia dolosa.
Infection and immunity 06, 2017 | Pubmed ID: 28348057
An Ocular Commensal Protects against Corneal Infection by Driving an Interleukin-17 Response from Mucosal γδ T Cells.
Immunity 07, 2017 | Pubmed ID: 28709803
Role of Microbiota in Strengthening Ocular Mucosal Barrier Function Through Secretory IgA.
Investigative ophthalmology & visual science 09, 2017 | Pubmed ID: 28892827
The Immunomodulatory Drug Glatiramer Acetate is Also an Effective Antimicrobial Agent that Kills Gram-negative Bacteria.
Scientific reports Nov, 2017 | Pubmed ID: 29142299
Frontline Science: Employing enzymatic treatment options for management of ocular biofilm-based infections.
Journal of leukocyte biology 06, 2019 | Pubmed ID: 30690787
MASTers of neutrophil homeostasis.
Journal of leukocyte biology 04, 2019 | Pubmed ID: 30794322
Neutrophil Extracellular Traps Confine Pseudomonas aeruginosa Ocular Biofilms and Restrict Brain Invasion.
Cell host & microbe Apr, 2019 | Pubmed ID: 30930127
Microglia and Neutrophils to the Rescue.
Trends in immunology 07, 2019 | Pubmed ID: 31133466
Mass Spectrometry-Based Quantitative Proteomics of Murine-Derived Polymorphonuclear Neutrophils.
Current protocols in immunology 09, 2019 | Pubmed ID: 31483107
Decoding communication patterns of the innate immune system by quantitative proteomics.
Journal of leukocyte biology 12, 2019 | Pubmed ID: 31556465
Looking into nerve damage in the cornea.
eLife 10, 2019 | Pubmed ID: 31592769
Tasked with a Challenging Objective: Why Do Neutrophils Fail to Battle Biofilms.
Pathogens (Basel, Switzerland) Dec, 2019 | Pubmed ID: 31817091
Label-Free Quantitative Proteomics Distinguishes General and Site-Specific Host Responses to Pseudomonas aeruginosa Infection at the Ocular Surface.
Proteomics 01, 2020 | Pubmed ID: 31874121
Neutrophil L-Plastin Controls Ocular Paucibacteriality and Susceptibility to Keratitis.
Frontiers in immunology , 2020 | Pubmed ID: 32318063
Quantitative Proteomic Profiling of Murine Ocular Tissue and the Extracellular Environment.
Current protocols in mouse biology Sep, 2020 | Pubmed ID: 32897649
Conjunctival Commensal Isolation and Identification in Mice
1Department of Medicine, Division of Infectious Diseases, Brigham and Women's Hospital, Harvard Medical School,
2Massachusetts Host-Microbiome Center, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School,
3Clinical Microbiology Laboratory, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School
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