Mack Sobhany

Structural analysis by X-ray crystallography and calorimetry of a haemagglutinin component (HA1) of the progenitor toxin from Clostridium botulinum.

Two-step mechanism that determines the donor binding specificity of human UDP-N-acetylhexosaminyltransferase.

Characterization of specific donor binding to alpha1,4-N-acetylhexosaminyltransferase EXTL2 using isothermal titration calorimetry.

The chondroitin polymerase K4CP and the molecular mechanism of selective bindings of donor substrates to two active sites.

The structural basis for a coordinated reaction catalyzed by a bifunctional glycosyltransferase in chondroitin biosynthesis.

Crystal structure of calmodulin binding domain of orai1 in complex with Ca2+ calmodulin displays a unique binding mode.

Phenobarbital indirectly activates the constitutive active androstane receptor (CAR) by inhibition of epidermal growth factor receptor signaling.

Nuclear Localization of the DNA Repair Scaffold XRCC1: Uncovering the Functional Role of a Bipartite NLS.

The Crystal Structure of the Ubiquitin-like Domain of Ribosome Assembly Factor Ytm1 and Characterization of Its Interaction with the AAA-ATPase Midasin.

Structural Analysis Reveals Features of Ribosome Assembly Factor Nsa1/WDR74 Important for Localization and Interaction with Rix7/NVL2.

Grc3 programs the essential endoribonuclease Las1 for specific RNA cleavage.

Interaction of the phosphorylated DNA-binding domain in nuclear receptor CAR with its ligand-binding domain regulates CAR activation.

Characterization of the molecular crosstalk within the essential Grc3/Las1 pre-rRNA processing complex.

Cryo-EM structure of the essential ribosome assembly AAA-ATPase Rix7.

Mitochondrial acetyl-CoA reversibly regulates locus-specific histone acetylation and gene expression.

Cryo-EM reveals active site coordination within a multienzyme pre-rRNA processing complex.

Cryo-EM Structures of the SARS-CoV-2 Endoribonuclease Nsp15.

Cryo-EM structures of the SARS-CoV-2 endoribonuclease Nsp15 reveal insight into nuclease specificity and dynamics.