use-of-bisection-to-reduce-mitochondrial-dna-in-the-bovine-oocyte

Use of Bisection to Reduce Mitochondrial DNA in the Bovine Oocyte

Interspecies somatic cell nuclear transfer (iSCNT) may be used to rescue endangered species, but two distinct populations of mitochondrial DNA (mtDNA) ...

Genus plc

Genus PLC

To study messenger ribonucleic acid (mRNA) and protein expressions of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) entry receptors (angiotensin 1-converting enzyme 2 [ACE2] and CD147) and proteases (transmembrane serine protease 2 [TMPRSS2] and cathepsin L [CTSL]) in human oocytes, embryos, and cumulus (CCs) and granulosa cells (GCs).

Human eggs, zygotes, and embryos express the receptor angiotensin 1-converting enzyme 2 and transmembrane serine protease 2 protein necessary for severe acute respiratory syndrome coronavirus 2 infection.

In vitro oocyte maturation is an assisted reproductive technology in which a meiotically immature oocyte (prophase I or germinal vesicle stage) is recovered from an antral follicle and matured in vitro prior to fertilization. This technology, although in widespread use in domestic livestock, is not typically implemented during human in vitro fertilization cycles. This review examines how in vitro oocyte maturation is currently used in the clinical setting, including the various ways in vitro oocyte maturation is defined in practice. The role of in vitro oocyte maturation in patient care and the major challenges for implementation are described. Efficiency and safety are critically explored. The role of in vitro oocyte maturation in oncofertility will also be discussed. Finally, the outlook for the future of clinical in vitro oocyte maturation is considered.

Present state and future outlook for the application of in vitro oocyte maturation in human infertility treatment.

To characterize fatty acid (FA) profile of commercially available albumin products and determine their effect on embryonic development.

Rebecca Krisher

Genus plc

Use of Bisection to Reduce Mitochondrial DNA in the Bovine Oocyte