Thomas W. Claydon

Closed-state inactivation induced in K(V)1 channels by extracellular acidification.

Proline scan of the HERG channel S6 helix reveals the location of the intracellular pore gate.

The Zebrafish Heart as a Model of Mammalian Cardiac Function.

Stabilization of the Activated hERG Channel Voltage Sensor by Depolarization Involves the S4-S5 Linker.

Loss-of-Function and Gain-of-Function Mutations in KCNQ5 Cause Intellectual Disability or Epileptic Encephalopathy.

Functional characterization of a novel hERG variant in a family with recurrent sudden infant death syndrome: Retracting a genetic diagnosis.

Investigating the state dependence of drug binding in hERG channels using a trapped-open channel phenotype.

Extracellular protons accelerate hERG channel deactivation by destabilizing voltage sensor relaxation.

Modulation of hERG K Channel Deactivation by Voltage Sensor Relaxation.

The hERG channel activator, RPR260243, enhances protective current early in the refractory period reducing arrhythmogenicity in zebrafish hearts.

Electrophysiological characterization of the hERG R56Q LQTS variant and targeted rescue by the activator RPR260243.

Ion channel model reduction using manifold boundaries.