low-dose-gamma-radiation-sterilization-for-decellularized-tracheal

Low-Dose Gamma Radiation Sterilization for Decellularized Tracheal Grafts

One of the main key aspects in ensuring that a transplant evolves correctly is the sterility of the medium. Decellularized tracheal transplantation ...

Universitat de Valencia Facultat de Medicina i Odontologia

Networking Research Center on Respiratory Diseases (CIBERER)

INCLIVA Biomedical Research Institute

Otitis media with effusion (OME) is the most common cause of conductive hearing loss in children and is strongly associated with primary ciliary dyskinesia (PCD). Approximately half of the children with PCD require otolaryngology care, posing a major problem in this population. Early diagnosis of PCD is critical in these patients to minimise the collateral damage related to OME. The current gold standard for PCD diagnosis requires determining ciliary structure defects by transmission electron microscopy (TEM) or clearly documenting ciliary dysfunction via digital high-speed video microscopy (DHSV). Although both techniques are useful for PCD diagnosis, they have limitations and need to be supported by new methodologies, including genetic analysis of genes related to PCD. In this article, we review classical and recently associated mutations related to ciliary alterations leading to PCD, which can be useful for early diagnosis of the disease and subsequent early management of OME.

Manuel Mata-Roig

Pathology Department

Universitat de Valencia Facultat de Medicina i Odontologia

Low-Dose Gamma Radiation Sterilization for Decellularized Tracheal Grafts

Manuel Mata-Roig

.css-o250i3{font-size:18px;font-family:Open Sans,sans-serif;line-height:21.6px;}Pathology Department

Universitat de Valencia Facultat de Medicina i Odontologia

Low-Dose Gamma Radiation Sterilization for Decellularized Tracheal Grafts

Pathology Department