insertion-flexible-neural-probes-using-rigid-stiffeners-attached-with

Insertion of Flexible Neural Probes Using Rigid Stiffeners Attached with Biodissolvable Adhesive

Microelectrode  arrays for neural interface devices that are made of biocompatible thin-film  polymer are expected to have extended functional lifetime ...

Lawrence Livermore National Laboratory

Metallic striped nanowires as multiplexed immunoassay platforms for pathogen detection.

M&eacute;talliques nanofils ray&eacute; comme plates-formes multiplex&eacute; test immunologique pour la d&eacute;tection des pathog&egrave;nes.

Nanofili a strisce metalliche come piattaforme multiplex immunoenzimatico per il rilevamento del patogeno.

Metallic nanoparticles suspended in aqueous solutions and functionalized with chemical and biological surface coatings are important elements in basic and applied nanoscience research. Many applications require an understanding of the electrokinetic or colloidal properties of such particles. We describe the results of experiments to measure the zeta potential of metallic nanorod particles in aqueous saline solutions, including the effects of pH, ionic strength, metallic composition, and surface functionalization state. Particle substrates tested include gold, silver, and palladium monometallic particles as well as gold/silver bimetallic particles. Surface functionalization conditions included 11-mercaptoundecanoic acid (MUA), mercaptoethanol (ME), and mercaptoethanesulfonic acid (MESA) self-assembled monolayers (SAMs), as well as MUA layers subsequently derivatized with proteins. For comparison, we present zeta potential data for typical charge-stabilized polystyrene particles. We compare experimental zeta potential data with theoretically predicted values for SAM-coated and bimetallic particles. The results of these studies are useful in predicting and controlling the aggregation, adhesion, and transport of functionalized metallic nanoparticles within microfluidic devices and other systems.

The zeta potential of surface-functionalized metallic nanorod particles in aqueous solution.

Les nanoparticules m&eacute;talliques dans des solutions aqueuses et fonctionnalis&eacute;s avec des rev&ecirc;tements de surface chimiques et biologiques sont des &eacute;l&eacute;ments importants dans la recherche fondamentale et appliqu&eacute;e des nanosciences. De nombreuses applications requi&egrave;rent une compr&eacute;hension des propri&eacute;t&eacute;s &eacute;lectrocin&eacute;tiques ou collo&iuml;dales de telles particules. Nous d&eacute;crivons les r&eacute;sultats d&#39;exp&eacute;riences visant &agrave; mesurer la potentiel z&ecirc;ta de particules m&eacute;talliques nanotige dans les solutions salines aqueuses, y compris les effets du pH, force ionique, la composition m&eacute;tallique et &eacute;tat de fonctionnalisation de surface. Substrats de particules test&eacute;s comprennent les particules monom&eacute;talliques or, argent et palladium, mais aussi des particules bim&eacute;talliques or/argent. Conditions de fonctionnalisation de surface inclus 11-mercaptound&eacute;canoate acide (MUA), acide mercapto&eacute;thanol (moi) et mercapto&eacute;thanesulfonique (MESA) Self-Assembled monocouches, ainsi que les couches MUA par la suite d&eacute;rivatis&eacute;s avec prot&eacute;ines. &Agrave; titre de comparaison, nous pr&eacute;sentons des donn&eacute;es sur le potentiel z&ecirc;ta pour les particules de polystyr&egrave;ne stabilis&eacute; frais typiques. Nous comparons les donn&eacute;es sur le potentiel z&ecirc;ta exp&eacute;rimental avec les valeurs pr&eacute;dites th&eacute;oriquement pour particules rev&ecirc;tus SAM et bim&eacute;talliques. Les r&eacute;sultats de ces &eacute;tudes sont utiles pour pr&eacute;dire et contr&ocirc;ler l&#39;agr&eacute;gation, adh&eacute;rence et transport de fonctionnalis&eacute;s nanoparticules m&eacute;talliques au sein de dispositifs microfluidiques et autres syst&egrave;mes.

Le potentiel z&ecirc;ta de particules fonctionnalis&eacute;s surface m&eacute;tallique nanotige en solution aqueuse.

Le nanoparticelle metalliche sospese in soluzioni acquose e funzionalizzato con rivestimenti chimici e biologici sono elementi importanti nella ricerca di base e applicata nanoscienza. Molte applicazioni richiedono la comprensione delle propriet&agrave; elettrocinetica o colloidale di tali particelle. Descriviamo i risultati di esperimenti per misurare il potenziale zeta di particelle metalliche nanorod in soluzioni saline acquose, compresi gli effetti del pH, forza ionica, composizione metallica e funzionalizzazione superficiale dello stato. Substrati di particella testati includono oro, argento e Palladio monometallici particelle cos&igrave; come particelle bimetallici oro/argento. Funzionalizzazione superficiale condizioni incluso acido 11-mercaptoundecanoic (MUA), mercaptoetanolo (ME) e mercaptoethanesulfonic acido (MESA) self-assembled monostrati (SAMs), come pure strati MUA successivamente derivatizzate con proteine. Per confronto, vi presentiamo dati potenziale zeta per particelle di polistirene tipiche carica-stabilizzato. Confrontiamo i dati di potenziale zeta sperimentale con valori teoricamente previsti per le particelle rivestite con SAM e bimetallici. I risultati di questi studi sono utili nel predire e controllare l&#39;aggregazione, adesione e trasporto delle nanoparticelle funzionalizzate metalliche all&#39;interno di dispositivi microfluidici e altri sistemi.

Satinderpall S. Pannu

Materials Engineering Division

Lawrence Livermore National Laboratory

Insertion of Flexible Neural Probes Using Rigid Stiffeners Attached with Biodissolvable Adhesive

Satinderpall S. Pannu

.css-o250i3{font-size:18px;font-family:Open Sans,sans-serif;line-height:21.6px;}Materials Engineering Division

Lawrence Livermore National Laboratory

Insertion of Flexible Neural Probes Using Rigid Stiffeners Attached with Biodissolvable Adhesive

Materials Engineering Division