Advanced Glycation End-Products Sensitize Human Sensory-Like Neuron Cells to Capsaicin-Induced Calcium InfluxGessica Sabrina de Assis Silva *1, Michelle Cristiane Bufalo *2,3, Marcelo Medina de Souza *2, Carlos DeOcesano-Pereira 2, Ana Marisa Chudzinski-Tavassi 2,3, Vanessa Olzon Zambelli 1,2
1Laboratory of Pain and Signaling, Butantan Institute, 2Center of Excellence in New Target Discovery, Butantan Institute, 3Innovation and Development Laboratory, Innovation and Development Center, Butantan Institute
Increased collagen-derived advanced glycation end products (AGEs) are consistently linked to painful diseases. Here, we investigated whether glycation sensitizes sensory neurons to capsaicin excitation.
