JoVE Logo

Zaloguj się

21.3 : Types of Receptors: Cell Surface Receptors

Cell-surface receptors, also known as transmembrane receptors, are cell surface, membrane-anchored (integral) proteins that bind to external ligand molecules. This type of receptor spans the plasma membrane and performs signal transduction, converting an extracellular signal into an intracellular signal. Ligands that interact with cell-surface receptors do not have to enter the cell that they affect. Cell-surface receptors are also called cell-specific proteins or markers because they are specific to individual cell types.

Each cell-surface receptor has three main components: an external ligand-binding domain called the extracellular domain, a hydrophobic membrane-spanning region called a transmembrane domain, and an intracellular domain inside the cell. The size and extent of each of these domains vary widely, depending on the type of receptor. Cell-surface receptors are involved in most of the signaling in multicellular organisms. There are three general categories of cell-surface receptors: ion channel-linked receptors, G-protein-linked receptors, and enzyme-linked receptors.

Because cell-surface receptor proteins are fundamental to normal cell functioning, it should be no surprise that a malfunction in any of these proteins could have severe consequences. Errors in the protein structures of certain receptor molecules have been shown to play a role in hypertension (high blood pressure), asthma, heart disease, and cancer.

This text is adapted from Openstax, Biology 2e, Chapter 9 Cell communication, Section 9.1: Signaling molecules and cellular receptors.

Tagi

Cell Surface ReceptorsTransmembrane ReceptorsSignal TransductionLigand binding DomainExtracellular DomainTransmembrane DomainIntracellular DomainIon Channel linked ReceptorsG protein linked ReceptorsEnzyme linked ReceptorsReceptor MalfunctionHypertensionAsthmaHeart DiseaseCancer

Z rozdziału 21:

article

Now Playing

21.3 : Types of Receptors: Cell Surface Receptors

Principles of Cell Signaling

16.7K Wyświetleń

article

21.1 : Przegląd sygnalizacji komórkowej

Principles of Cell Signaling

20.0K Wyświetleń

article

21.2 : Rodzaje cząsteczek sygnałowych

Principles of Cell Signaling

10.1K Wyświetleń

article

21.4 : Rodzaje receptorów: Receptory wewnętrzne

Principles of Cell Signaling

21.9K Wyświetleń

article

21.5 : Montaż kompleksów sygnalizacyjnych

Principles of Cell Signaling

5.7K Wyświetleń

article

21.6 : Interakcje między szlakami sygnałowymi

Principles of Cell Signaling

6.2K Wyświetleń

article

21.7 : Wzmacnianie sygnałów za pośrednictwem drugich komunikatorów

Principles of Cell Signaling

6.7K Wyświetleń

article

21.8 : Wzmacnianie sygnałów za pomocą kaskady enzymatycznej

Principles of Cell Signaling

8.3K Wyświetleń

article

21.9 : Różnorodność odpowiedzi sygnalizacji komórkowej

Principles of Cell Signaling

6.4K Wyświetleń

article

21.10 : Pętle sprzężenia zwrotnego sygnalizacji komórkowej

Principles of Cell Signaling

6.2K Wyświetleń

article

21.11 : Sygnalizacja komórkowa w roślinach

Principles of Cell Signaling

5.6K Wyświetleń

article

21.12 : Hormony roślinne

Principles of Cell Signaling

5.0K Wyświetleń

JoVE Logo

Prywatność

Warunki Korzystania

Zasady

Badania

Edukacja

O JoVE

Copyright © 2025 MyJoVE Corporation. Wszelkie prawa zastrzeżone