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Bioengineering

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One Minute, Sub-One-Watt Photothermal Tumor Ablation Using Porphysomes, Intrinsic Multifunctional Nanovesicles

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10.7K Views

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09:51 min

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September 17th, 2013

DOI :

10.3791/50536-v

September 17th, 2013

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Cheng S. Jin¹^,²^,³, Jonathan F. Lovell⁴, Gang Zheng¹^,²^,³

¹Department of Pharmaceutical Sciences, University of Toronto, ²The Institute of Biomaterials and Biomedical Engineering, University of Toronto, ³Ontario Cancer Institute, Campbell Family Institute For Cancer Research and Techna Institute, ⁴Department of Biomedical Engineering, University at Buffalo, The State University of New York

Podsumowanie

We developed novel intrinsic multifunctional nanovesicles called porphysomes, which have structure-dependent fluorescence self-quenching and unique photothermal properties, thus functioning as potent photothermal therapy agents. We formulated porphysomes using high pressure extrusion and investigated their photothermal therapy efficacy in a xenograft tumor model.

Przeglądaj więcej filmów

Photothermal Tumor Ablation

Intrinsic Multifunctional Nanovesicles

Photosensitizer

Pyropheophorbide

Liposome like Spherical Vesicles

Extinction Coefficients

Fluorescence Self quenching

Photothermal Efficacy

High Pressure Extrusion

Tumor Temperature Increase

Laser Irradiation

Thermal Ablation

Photothermal Therapy PTT

Rozdziały w tym wideo

0:05

Title

1:41

Preparation of Porphysomes

5:27

In vivo Photothermal Therapy

9:23

Conclusion

7:43

Porphysome Characterization and Tumor Treatment Results

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