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Application and Methodology of the Non-destructive 19F Time-domain NMR Technique to Measure the Content in Fluorine-containing Drug Products

8.3K Views

09:24 min

August 22nd, 2017

DOI :

10.3791/55850-v

August 22nd, 2017


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19F NMR

Rozdziały w tym wideo

0:05

Title

0:51

Preparation of Samples and NMR Instrument for 19F TD-NMR Measurement

8:29

Conclusion

1:56

Measurement of the T1 or Longitudinal Relaxation Time for Standard Pure API Samples

3:23

Measuring Calibration Samples with Pure API

4:29

Measuring Drug Product Samples as Tablets

6:59

Calculation of the Fluorinated API Drug Weight in the Formulated Drug Product Using the Calibration Curves

7:33

Results: Evaluation of the Average Drug Content of Cinacalcet in Tablet Dosage Forms by Low-field Fluorine-19 Time-domain Nuclear Magnetic Resonance

4:59

Generation of Calibration Curves with Pure API Samples and Adding the Data from Drug Product Samples as Tablets in the Calibration Curve

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