Experimental Models to Study the Neuroprotection of Acidic Postconditioning Against Cerebral Ischemia

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7.4K Views

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10:13 min

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July 31st, 2017

DOI :

10.3791/55931-v

July 31st, 2017

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Yanrong Zheng*¹, Zhe Shen*¹, Xiaoli Wu¹, Lei Jiang¹, Weiwei Hu¹, Zhong Chen¹, Xiangnan Zhang¹

¹Institute of Pharmacology & Toxicology, College of Pharmaceutical Sciences, Department of Pharmacology, Key Laboratory of Medical Neurobiology of The Ministry of Health of China, Zhejiang Province Key Laboratory of Neurobiology, Zhejiang University

Podsumowanie

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Keywords Neuroprotection

Acidic Postconditioning

Cerebral Ischemia

Cortico Striatal Slice Model

Middle Cerebral Artery Occlusion Model

Ischemic Brain Injury

Stroke Therapy

Acidosis Postconditioning

Brain Slice Preparation

Glucose free ACSF

Acidic ACSF

Synaptic Function Recovery

Rozdziały w tym wideo

0:05

Title

0:57

Cortical Slice Preparation

2:43

Oxygen-glucose Deprivation and Acidic Postconditioning

4:03

Determination of Slice Viability

5:04

Middle Cerebral Artery Occlusion

7:22

Reperfusion and Acidic Postconditioning

8:16

Results: Acidic Preconditioning Protects Against Reperfusion Injury

9:32

Conclusion

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