A Human Blood-Brain Interface Model to Study Barrier Crossings by Pathogens or Medicines and Their Interactions with the Brain

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8.5K Views

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07:52 min

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April 9th, 2019

DOI :

10.3791/59220-v

April 9th, 2019

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Anaelle da Costa*¹, Christophe Prehaud*¹, Florian Bakoa¹, Philippe Afonso², Pierre-Emmanuel Ceccaldi², Pierre Lafaye³, Monique Lafon¹

¹Institut Pasteur, CNRS UMR 3569, Unité de Neuroimmunologie Virale, ²Institut Pasteur, Unité d’Epidémiologie et de Pathophysiologie des Virus Oncogènes, Université Sorbonne Paris Cité/Paris Diderot, ³Institut Pasteur, PFIA, DTPS

Podsumowanie

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Human Blood Brain Interface

Permeability Validation

Lucifer Yellow

Fibroblast Serum FBS

Transport Buffer

Rozdziały w tym wideo

0:04

Title

0:36

Human Cerebral Microvascular Endothelial Cell (hCMEC)/D3 Insert Coating and Blood Brain Barrier (BBB) Preparation

2:48

BBB-Minibrain Endothelial Permeability Validation

3:38

BBB Crossing and Multiplication of Yellow Fever Viruses in the Minibrain and Biomolecule BBB Crossing and Brain Cell Targeting

5:22

Results: Representative BBB-Minibrain Testing of Neuroinvasive Variants and Biomolecule Properties

7:19

Conclusion

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