Visualization and Quantification of Brown and Beige Adipose Tissues in Mice using [¹⁸F]FDG Micro-PET/MR Imaging

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2.9K Views

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08:31 min

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July 1st, 2021

DOI :

10.3791/62460-v

July 1st, 2021

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Qing Liu*¹^,², Kel Vin Tan*³, Hing-Chiu Chang³, Pek-Lan Khong³, Xiaoyan Hui¹^,²^,⁴

¹State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, ²Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, ³Department of Diagnostic Radiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, ⁴School of Biomedical Sciences, Institute of Vascular Medicine, Chinese University of Hong Kong

Podsumowanie

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Thermogenic Adipocytes

Micro PET MR Imaging

C57 Black 6 Mouse

Meloxicam Administration

Automated Scans

T1 weighted MRI

T2 weighted MRI

Attenuation Correction

F 18 Isotope

Imaging Parameters

Rozdziały w tym wideo

0:05

Introduction

1:10

Interscapular Brown Adipose Tissue (iBAT) Dissection

1:52

Micro-Positron Emission Tomography (PET)/Magnetic Resonance (MR) Setup

2:53

Micro-PET/MR Calibration and [¹⁸F]FDG Injection

4:28

Micro-PET/MR Acquisition

6:11

Results: [¹⁸F]FDG Uptake in iBAT and Inguinal White Adipose Tissue (iWAT) After Cold Treatment

7:21

Conclusion

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Visualization and Quantification of Brown and Beige Adipose Tissues in Mice using [¹⁸F]FDG Micro-PET/MR Imaging