This study was conducted in strict accordance with the protocols established by the Institutional Review Boards of Zhongshan Hospital and Minhang Hospital, both affiliated with Fudan University (approval numbers: 2021-042 and 2021-037-01X, respectively). All participating patients provided informed written consent. Exclusion criteria were rigorously applied: patients with foraminal stenosis, multi-level stenosis, significant instability, a medical history of previous lumbar spine surgical interventions, or those presenting with degenerative spondylolisthesis of grade 2 or higher were considered ineligible for the study.
1. Patient preparation
<ol>
	<li>Perform the surgery under general anesthesia following approved protocols.</li>
	<li>Place the patient in a prone position on a radiopermeable operating table, and flex appropriately (Figure 2).</li>
	<li>Select the responsible lumbar segment causing clinical symptoms as the operative segment. 
	NOTE: For the convenience of description, the most common L4-5 stenosis was selected as an example to describe the surgical technique in this report. Other segments are similar to L4-5.</li>
	<li>Generally, select the more symptomatic side as the side of the surgical approach. In this report, the left side was selected as the surgical side for introduction.</li>
	<li>Determine the skin incision and working channel docking point on the anteroposterior view of fluoroscopy. Select the lateral edge of the left lumbar 4-5 interlaminar window as the docking target, and select its vertical projection on the body surface as the entry point of the skin.</li>
	<li>After the patient is routinely sterilized and draped, make a 10 mm stab wound in the skin deep to the fascia layer. Introduce a pencil-like rod with a 2 mm diameter to touch the bone (left L4-5 articular) under fluoroscopic guidance.</li>
</ol>
2. Insertion of endoscope
<ol>
	<li>Gradually expand the vertebral muscle and fascia using the soft tissue extender (see Table of Materials). Then, insert the 10 mm work sleeve with an oblique mouth. Verify the position of the working sleeve with fluoroscopy (Figure 3).</li>
	<li>Introduce the endoscopic surgical system (15&#176; viewing angle, outer diameter 10 mm, working channel diameter of 6 mm, and working length 125 mm), and perform all the subsequent steps under constant irrigation with endoscopic visualization.</li>
</ol>
3. Surgical procedure
<ol>
	<li>Under high-definition endoscopic visualization, dissect the soft tissue off the bone, and perform hemostasis using the radiofrequency probe (see Table of Materials). Confirm the presence of important anatomical structures, including the lower half of the left L4 lamina, left L4-5 facet joint, the upper 1/3 of the left L5 lamina, the base of the spinous process of L4 and L5, and the proliferative ligamentum flavum within the lumbar 4-5 interlaminar window1.</li>
	<li>Initiate ipsilateral bony decompression, starting from the L4 lamina. Remove the lower part of the L4 lamina, the medial part of the L4-5 articular process, and the upper edge of the L5 lamina using a 3.5 mm endoscopic diamond bur, trephine, and Kerrison Rongeur (see Table of Materials).
	<ol>
		<li>Utilize the 5 mm diameter endoscopic trephine (see Table of Materials) to effectively remove the L4 inferior articular process, which is surrounded by joint capsule and ligament. Separate and remove the superficial layer of the ligamentum flavum from the inner layer with a rongeur. 
		NOTE: Retain the inner layer of the ligamentum flavum in place, as it is tightly attached to the inner surface of the lamina and the medial border of the L5 superior articular process.</li>
		<li>The goal of lamina decompression in this step is to expose the cephalad and caudal free margins of the deep layer of the ligamentum flavum. Cut the medial border of the L5 superior articular process to free the lateral margin of the ligamentum flavum.</li>
	</ol>
	</li>
	<li>Proceed with contralateral bony decompression, starting from the base of the spinous process of L4. Shave the base of the spinous process to create sufficient space, facilitating the insertion of the working cannula (working channel diameter of 6 mm, and working length 125 mm) towards the contralateral side.
	<ol>
		<li>Polish the contralateral lower part of the L4 lamina from the inner surface to expose the cephalad free margin of the ligamentum flavum.</li>
		<li>Similarly, shave the base of the L5 spinous process and remove the upper edge of the L5 lamina to expose the caudal free margin of the ligamentum flavum. Detach the contralateral lateral margin of the ligamentum flavum from the contralateral L5 superior articular process.</li>
		<li>Remove the medial part of the L5 superior articular process using a diamond bur and/or Kerrison Rongeur.</li>
	</ol>
	</li>
	<li>After completing bony decompression and releasing ligamentum flavum attachments, remove the ligamentum flavum either in an en bloc manner or in a piecemeal manner.</li>
	<li>Remove the inner layer of the ligamentum flavum at the end of the operation. This step helps protect nerve elements during osteotomy and reduces vision blurring caused by epidural hemorrhage.</li>
	<li>Explore both lateral recesses to ensure thorough decompression of bilateral traversing nerves. If necessary, perform further decompression of the ligamentum flavum and its attached bony structures using endoscopic Kerrison Rongeur.</li>
	<li>Conclude the procedure when the dura and bilateral traversing nerve roots are free. Perform careful hemostasis using endoscopic radiofrequency bipolar. Close the skin incision with one or two stitches (approximately 1 cm).</li>
</ol>
4. Post-operative care and follow-up
<ol>
	<li>After lying down for 8 h post-surgery, ask the patients to walk, but ensure that they wear support around their waist.</li>
	<li>Provide proper guidance to the patients on exercises to aid in their recovery. Carefully monitor and address any swelling or pain that may occur after the operation.</li>
	<li>After 7 days of the surgery, encourage them to gradually resume their usual routines. Conduct regular check-ins to assess their healing progress.</li>
</ol>

Treating Lumbar Spinal Stenosis with a Minimally Invasive Spine Surgery

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	<li>Benini, A. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Lumbar+spinal+stenosis.+An+overview+50+years+following+initial+description.">Lumbar spinal stenosis. An overview 50 years following initial description.</a> Der Orthopade. 22 (4), 257-266 (1993).</li><li>Cinotti, G., Postacchini, F., Fassari, F., Urso, S. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Predisposing+factors+in+degenerative+spondylolisthesis:+a+radiographic+and+CT+study.">Predisposing factors in degenerative spondylolisthesis: a radiographic and CT study.</a> International Orthopaedics. 21, 337-342 (1997).</li><li>Torudom, Y., Dilokhuttakarn, T. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Two+portal+percutaneous+endoscopic+decompression+for+lumbar+spinal+stenosis:+preliminary+study.">Two portal percutaneous endoscopic decompression for lumbar spinal stenosis: preliminary study.</a> Asian Spine Journal. 10 (2), 335 (2016).</li><li>Atlas, S. J., Keller, R. B., Robson, D., Deyo, R. A., Singer, D. E. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Surgical+and+nonsurgical+management+of+lumbar+spinal+stenosis:+four-year+outcomes+from+the+maine+lumbar+spine+study.">Surgical and nonsurgical management of lumbar spinal stenosis: four-year outcomes from the maine lumbar spine study.</a> Spine. 25 (5), 556-562 (2000).</li><li>Atlas, S. J., Keller, R. B., Wu, Y. A., Deyo, R. A., Singer, D. E. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Long-term+outcomes+of+surgical+and+nonsurgical+management+of+lumbar+spinal+stenosis:+8+to+10+year+results+from+the+maine+lumbar+spine+study.">Long-term outcomes of surgical and nonsurgical management of lumbar spinal stenosis: 8 to 10 year results from the maine lumbar spine study.</a> Spine. 30 (8), 936-943 (2005).</li><li>Malmivaara, A., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Lumbar+spinal+research+group.+surgical+or+nonoperative+treatment+for+lumbar+spinal+stenosis?:+a+randomized+controlled+trial.">Lumbar spinal research group. surgical or nonoperative treatment for lumbar spinal stenosis?: a randomized controlled trial.</a> Spine. 32 (1), 1-8 (2007).</li><li>Parker, S. L., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Cost-effectiveness+of+multilevel+hemilaminectomy+for+lumbar+stenosis-associated+radiculopathy.">Cost-effectiveness of multilevel hemilaminectomy for lumbar stenosis-associated radiculopathy.</a> The Spine Journal. 11 (8), 705-711 (2011).</li><li>Parker, S. L., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Two-year+comprehensive+medical+management+of+degenerative+lumbar+spine+disease+(lumbar+spondylolisthesis,+stenosis,+or+disc+herniation):+a+value+analysis+of+cost,+pain,+disability,+and+quality+of+life.">Two-year comprehensive medical management of degenerative lumbar spine disease (lumbar spondylolisthesis, stenosis, or disc herniation): a value analysis of cost, pain, disability, and quality of life.</a> Journal of Neurosurgery: Spine. 21 (2), 143-149 (2014).</li><li>Fox, M. W., Onofrio, B. M., Hanssen, A. D. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Clinical+outcomes+and+radiological+instability+following+decompressive+lumbar+laminectomy+for+degenerative+spinal+stenosis:+a+comparison+of+patients+undergoing+concomitant+arthrodesis+versus+decompression+alone.">Clinical outcomes and radiological instability following decompressive lumbar laminectomy for degenerative spinal stenosis: a comparison of patients undergoing concomitant arthrodesis versus decompression alone.</a> Journal of Neurosurgery. 85 (5), 793-802 (1996).</li><li>J&#246;nsson, B., Annertz, M., Sj&#246;berg, C., Str&#246;mqvist, B. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=A+prospective+and+consecutive+study+of+surgically+treated+lumbar+spinal+stenosis:+part+II:+five-year+follow-up+by+an+independent+observer.">A prospective and consecutive study of surgically treated lumbar spinal stenosis: part II: five-year follow-up by an independent observer.</a> Spine. 22 (24), 2938-2944 (1997).</li><li>Ghogawala, Z., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Laminectomy+plus+fusion+versus+laminectomy+alone+for+lumbar+spondylolisthesis.">Laminectomy plus fusion versus laminectomy alone for lumbar spondylolisthesis.</a> New England Journal of Medicine. 374 (15), 1424-1434 (2016).</li><li>Komp, M., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Bilateral+spinal+decompression+of+lumbar+central+stenosis+with+the+full-endoscopic+interlaminar+versus+microsurgical+laminotomy+technique:+a+prospective,+randomized,+controlled+study.">Bilateral spinal decompression of lumbar central stenosis with the full-endoscopic interlaminar versus microsurgical laminotomy technique: a prospective, randomized, controlled study.</a> Pain Physician. 18 (1), 61 (2015).</li><li>Ito, F., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Step-by-step+sublaminar+approach+with+a+newly-designed+spinal+endoscope+for+unilateral-approach+bilateral+decompression+in+spinal+stenosis.">Step-by-step sublaminar approach with a newly-designed spinal endoscope for unilateral-approach bilateral decompression in spinal stenosis.</a> Neurospine. 16 (1), 41 (2019).</li><li>Lee, C. W., Yoon, K. J., Jun, J. H. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Percutaneous+endoscopic+laminotomy+with+flavectomy+by+uniportal,+unilateral+approach+for+the+lumbar+canal+or+lateral+recess+stenosis.">Percutaneous endoscopic laminotomy with flavectomy by uniportal, unilateral approach for the lumbar canal or lateral recess stenosis.</a> World Neurosurgery. 113, e129-e137 (2018).</li><li>McGrath, L. B., White-Dzuro, G. A., Hofstetter, C. P. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Comparison+of+clinical+outcomes+following+minimally+invasive+or+lumbar+endoscopic+unilateral+laminotomy+for+bilateral+decompression.">Comparison of clinical outcomes following minimally invasive or lumbar endoscopic unilateral laminotomy for bilateral decompression.</a> Journal of Neurosurgery: Spine. 30 (4), 491-499 (2019).</li><li>Pairuchvej, S., Muljadi, J. A., Ho, J. C., Arirachakaran, A., Kongtharvonskul, J. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Full-endoscopic+(bi-portal+or+uni-portal)+versus+microscopic+lumbar+decompression+laminectomy+in+patients+with+spinal+stenosis:+systematic+review+and+meta-analysis.">Full-endoscopic (bi-portal or uni-portal) versus microscopic lumbar decompression laminectomy in patients with spinal stenosis: systematic review and meta-analysis.</a> European Journal of Orthopaedic Surgery &amp; Traumatology. 30, 595-611 (2020).</li><li>Kim, H. S., Wu, P. H., Jang, I. T. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Lumbar+endoscopic+unilateral+laminotomy+for+bilateral+decompression+outside-in+approach:+a+proctorship+guideline+with+12+steps+of+effectiveness+and+safety.">Lumbar endoscopic unilateral laminotomy for bilateral decompression outside-in approach: a proctorship guideline with 12 steps of effectiveness and safety.</a> Neurospine. 17 (Suppl 1), S99 (2020).</li></ol>

The authors have nothing to disclose.

With the progressive evolution of percutaneous endoscopic spine surgery and clinicians&#39; profound comprehension of endoscopic procedures, the therapeutic indications for endoscopic lumbar interventions have expanded to encompass all manifestations of LSS, branching out from merely addressing lumbar disc herniation. The spectrum of endoscopic management for LSS includes stenosis decompression, contralateral decompression, and fusion facilitated by endoscopic visualization. An increasing volume of research underscores t...

Degenerative lumbar spinal stenosis (DLSS) can result from alterations in bony, discal, capsular, or ligamentary anatomical structures. Clinically, LSS presents with a range of symptoms, including radiating sciatic pain in the legs, neurogenic claudication during ambulation, and sensory disturbances, all of which significantly affect patients&#39; quality of life1,2,3. An initial conservative management period of two months is the recommended therapeutic approach for LSS. If conservative measures prove ineffective, transitioning to surgical decompression therapy becomes the subsequent recommendation.
Historically, open laminectomy has been the traditional surgical approach for addressing spinal stenosis. Peer-reviewed studies have confirmed its safety and cost-effectiveness, with outcomes showing notable superiority compared to non-surgical interventions4,5,6,7,8. However, the complexities involved in achieving comprehensive bony decompression of neural components can introduce the risk of segmental spinal instability. This may lead to symptom recurrence or a subsequent need for arthrodesis9,10. Distinctively, Ghogawala et al.11 documented that approximately 34% of patients, after undergoing traditional laminectomy for lumbar spinal stenosis with concomitant stable spinal spondylolisthesis, required revision surgery within four years post-operatively.
Over the past five decades, a discernible shift toward minimally invasive spinal surgical procedures has become evident. The overarching objective has been to reduce approach-related tissue disruption and subsequently mitigate post-operative discomfort and disability. This transition aligns seamlessly with the advent and progression of percutaneous endoscopic spine surgery.
Synchronized with advancements in endoscopic technology and a deepened understanding of endoscopic anatomical intricacies, contemporary endoscopic spine surgeons are now equipped to address a spectrum of LSS presentations safely and effectively. Specifically, lumbar endoscopic unilateral laminotomy for bilateral decompression (LE-ULBD) has gained traction as a favored modality for LSS management12,13,14,15,16,17(Figure 1). Paramount benefits of LE-ULBD include minimal incision requirements, avoidance of soft tissue disruption and muscular denervation, along with improved visualization.
Between May 2017 and May 2021, our institution employed the LE-ULBD technique to manage 132 patients with LSS. Relevant technical details and outcomes over a two-year follow-up period are elucidated herein. Based on these findings, LE-ULBD emerges as a minimally invasive, effective, and secure modality, positioning it as a viable alternative therapeutic strategy for patients diagnosed with lumbar central canal stenosis and/or lateral recess stenosis.

<table border="1" fo:keep-together.within-page="1" fo:keep-with-next.within-page="always">
	<tbody>
		<tr>
			<td>Kerrison Rongeur&#160;</td>
			<td>Joimax GmbH, Karlsruhe, Germany</td>
			<td></td>
			<td></td>
		</tr>
		<tr>
			<td>The endoscopic high-speed&#160;diamond burr</td>
			<td>NSK-Nakanishi International, Co., Ltd., Osaka, Japan</td>
			<td>Primado P200-RA330</td>
			<td></td>
		</tr>
		<tr>
			<td>The endoscopic surgical system Delta</td>
			<td>Joimax GmbH, Karlsruhe, Germany</td>
			<td></td>
			<td></td>
		</tr>
		<tr>
			<td>The radiofrequency probe</td>
			<td>Elliquence LLC, Baldwin, New York</td>
			<td>Trigger-FlexR Bipolar System</td>
			<td></td>
		</tr>
		<tr>
			<td>Trephine</td>
			<td>Joimax GmbH, Karlsruhe, Germany</td>
			<td></td>
			<td></td>
		</tr>
	</tbody>
</table>

percutaneous endoscopic unilateral-approach bilateral decompression for lumbar spinal stenosis

Lumbar spinal stenosis (LSS) involves the narrowing of the spinal canal due to degenerative changes in the vertebral joints, intervertebral discs, and ligaments. LSS encompasses central canal stenosis (CCS), lateral recess stenosis (LRS), and intervertebral foramen stenosis (IFS). The utilization of lumbar endoscopic unilateral laminotomy for bilateral decompression (LE-ULBD) has gained popularity in the treatment of CCS and LRS. This popularity is attributed to the rapid development of endoscopic instruments and the progress of endoscopic philosophy.
In this technical report, a detailed introduction to the steps and key points of LE-ULBD is provided. Simultaneously, a retrospective review of 132 consecutive patients who underwent LE-ULBD for central canal and/or lateral recess stenosis was conducted. The outcomes after more than two years of follow-up were assessed using the visual analogue score (VAS), Oswestry Disability Index (ODI), Japanese Orthopaedic Association (JOA) scores, and the modified MacNab criteria to evaluate surgical efficacy. All 132 patients underwent LE-ULBD successfully. Among them, 119 patients were rated as "excellent," while 13 patients were rated as "good" based on the modified MacNab criteria during the last follow-up. Incidental dural tears occurred in four cases, but there were no post-operative epidural hematomas or infections. The experience demonstrates that LE-ULBD is a less invasive, effective, and safe approach. It can be considered as an alternative option for treating patients with lumbar central canal stenosis and/or lateral recess stenosis.

Author Spotlight: Scope of LE-ULBD as a Safe, Effective, and Minimally Invasive Approach to Treat Lumbar Spinal Stenosis

Percutaneous Endoscopic Unilateral-Approach Bilateral Decompression for Lumbar Spinal Stenosis

The present protocol describes the steps and the key points of lumbar endoscopic unilateral laminotomy for bilateral decompression, LE-ULBD. This technique is used to treat degenerative lumbar spinal stenosis. The paramount advantage is that LE-ULBD provides an unparalleled clear visualization of the surgical field while reducing surgical-related trauma.Endoscopic spine surgery was initially used for lumbar disc herniation. However, it had evolved dramatically in recent years with the rapid development of endoscopic equipment and technological innovations. We have always been committed to broaden the scope of indications of spinal endoscopic technique.For example, we are developing percutaneous full-endoscopic C2 ganglionectomy to treat intractable occipital neuralgia.

Outcome evaluation
Surgical results were assessed using the Visual Analog Scale (VAS) scores for leg and back pain, Japanese Orthopaedic Association (JOA) Scores, Oswestry Disability Index (ODI) scores, and the modified MacNab standard12,15,17. These indicators were measured pre-operatively and at two days, six months, ...

Read this Scientific Article Protocol about Percutaneous Endoscopic Unilateral-Approach Bilateral Decompression for Lumbar Spinal Stenosis at JoVE.com

The present protocol describes the steps and key points of lumbar endoscopic unilateral laminotomy for bilateral decompression for the treatment of degenerative lumbar spinal stenosis.

Lumbar spinal stenosis (LSS) involves the narrowing of the spinal canal due to degenerative changes in the vertebral joints, intervertebral discs, and ...

percutaneous-endoscopic-unilateral-approach-bilateral-decompression

Research

JoVE Journal

Medicine

248 Views.  Minhang Hospital, Fudan University. The present protocol describes the steps and the key points of lumbar endoscopic unilateral laminotomy for bilateral decompression, LE-ULBD. This technique is used to treat degenerative lumbar spinal stenosis. The paramount advantage is that LE-ULBD provides an unparalleled clear visualization of the surgical field while reducing surgical-related trauma.Endoscopic spine surgery was initially used for lumbar disc herniation. However, it had evolved dramatically in recent years with the ...