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Micro-Computed Tomography Analysis of the Knee in Aged Dunkin-Hartley Guinea Pigs after Intra Articular Injection

Please note that all translations are AI generated. Click here for the English version.

195 Views

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07:10 min

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August 2nd, 2024

DOI :

10.3791/66053-v

August 2nd, 2024

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Jen X. Xu¹, Frank Z. Xu², Amelia Furbish¹, Yuri K. Peterson¹, Patrick M. Woster¹, Alicia M. Braxton³

¹Drug Discovery and Biomedical Sciences, Medical University of South Carolina, ²Department of Biomedical Science, The University of Alabama at Birmingham, ³Department of Comparative Medicine, Medical University of South Carolina

Podsumowanie

Dunkin-Hartley guinea pigs are an established animal model for osteoarthritis research. Such studies may benefit from intra-articular injections for various reasons, including investigating novel agents or treating disease. We describe a methodology for intra-articular knee injections in Guinea pigs and subsequent micro-computed tomography analysis assessing arthritis-associated knee changes.

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Micro Computed Tomography

Dunkin Hartley Guinea Pigs

Intraarticular Injection

Bone Mineral Density

Trabecular Thickness

Quantitative Analysis

Aseptic Technique

Drug Distribution

Study Variability

Therapeutic Agents

Rozdziały w tym wideo

0:05

Introduction

1:25

Intra-Articular Injection Preparations

1:57

Intra-Articular Injection

2:30

Recovery from Intra-Articular Injection

3:00

Image Processing for Evaluating Bone Microarchitectural Parameters

3:19

Collection of Microarchitectural Data from Reconstructed Images

4:16

Representative Results

5:44

Conclusion

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