The scope of our research is the model dolichoectasia in a transgenic mouse model to see the maximum impact that vascular changes have on Alzheimer's disease pathology. We are able to show that a single dose of elastase injection into the Cisterna magna of mice is able to cause dilatation up to the three months. Not much is known about individuals who suffer from both vascular dementia and Alzheimer's disease.
We hope to bridge this gap by causing vascular changes in these transgenic mouse model to try and understand the pathogenesis of this form of mixed dementia. Previous studies were able to show that dilatation lasts up to two weeks, in our study, we showed that dilatation lasts up to three months with a low mortality during our surgical procedure. Successful dilatation of large blood vessel in a transgenic mouse model provides us with the opportunity to test drugs to prevent or improve vascular changes in Alzheimer's disease.
